INT82077

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 32
Total Number 37
Disease Relevance 17.90
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
adipocyte 8
brain 6
fat 6
plasma 4
neurons 4
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 4 99.08 Very High Very High Very High
Thalamus 45 98.56 Very High Very High Very High
Hippocampus 85 97.44 Very High Very High Very High
Pain threshold 12 96.52 Very High Very High Very High
Bile 64 96.32 Very High Very High Very High
Intracerebroventricular 129 96.08 Very High Very High Very High
Inflammation 147 95.92 Very High Very High Very High
Neuropeptide 15 93.88 High High
antagonist 8 88.36 High High
bDMF 38 85.88 High High
Disease Link Frequency Relevance Heat
Obesity 503 100.00 Very High Very High Very High
Body Weight 421 100.00 Very High Very High Very High
Congenital Anomalies 18 100.00 Very High Very High Very High
Pancreatitis 12 100.00 Very High Very High Very High
Eating Disorder 26 99.66 Very High Very High Very High
Overweight 18 99.46 Very High Very High Very High
Stress 98 99.44 Very High Very High Very High
Sprains And Strains 56 99.32 Very High Very High Very High
Insulin Resistance 80 99.28 Very High Very High Very High
Nociception 12 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We employed both immunohistochemistry and in situ hybridization to see whether LS injection leads to leptin overexpression in the brain.
Spec (whether) Positive_regulation (leads) of Gene_expression (overexpression) of leptin in brain
1) Confidence 0.70 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.62 Pain Relevance 0.13
This was accompanied an increase in leptin expression in neurons and peripheral adipose tissues.
Positive_regulation (accompanied) of Gene_expression (expression) of leptin in neurons
2) Confidence 0.70 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.29 Pain Relevance 0.12
Because LS caused marked increase in leptin production in bovine endothelial cells and because leptin is involved in regulation of body weight we hypothesized that LS might also regulate leptin expression in the brain.
Positive_regulation (increase) of Gene_expression (production) of leptin in endothelial cells associated with body weight
3) Confidence 0.70 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.70 Pain Relevance 0.12
Some of these processes (e.g., angiogenesis), though not all, might be secondary to increased leptin expression.
Positive_regulation (increased) of Gene_expression (expression) of leptin
4) Confidence 0.70 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.46 Pain Relevance 0.13
Adipocyte leptin mRNA remained low during the lights-on phase but increased at the onset of the lights-off phase (1900 h) and remained elevated through the dark phase. 4) Hypothalamic leptin-R gene expression, like that of adipocyte leptin gene expression, rose abruptly at the onset of nocturnal feeding behavior but receded progressively to low range thereafter. 5) On the other hand, a dichotomy in the daily rise in adipocyte leptin gene expression and leptin secretion was observed in FF rats.
Positive_regulation (elevated) of Gene_expression (expression) of leptin-R in adipocyte
5) Confidence 0.68 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.44 Pain Relevance 0.13
The elevated levels of plasma leptin as wells as the increased mRNAs expression of the leptin receptors in placenta indicate the significant role of the hormone in fetal growth and development.
Positive_regulation (increased) of Gene_expression (expression) of leptin in placenta
6) Confidence 0.65 Published 2006 Journal Reprod Biol Section Abstract Doc Link 16967091 Disease Relevance 0 Pain Relevance 0.07
Recent evidence indicates that glucocorticoids induce leptin synthesis and secretion and that, conversely, leptin participates in the regulation of HPA axis function [29].
Positive_regulation (induce) of Gene_expression (synthesis) of leptin
7) Confidence 0.57 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1090442 Disease Relevance 0.72 Pain Relevance 0.38
To see whether the effect on leptin synthesis was specific we also performed immunohistochemistry for GM-CSF and TNF?
Spec (whether) Positive_regulation (on) of Gene_expression (synthesis) of leptin
8) Confidence 0.50 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.30 Pain Relevance 0.11
To see whether the effect on leptin synthesis was specific we also performed immunohistochemistry for GM-CSF and TNF?
Spec (whether) Positive_regulation (for) of Gene_expression (synthesis) of leptin
9) Confidence 0.50 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.31 Pain Relevance 0.16
These results suggest that hyperleptinemia may mediate "renal" and "vascular" leptin resistance observed in obesity.
Spec (may) Positive_regulation (mediate) of Gene_expression (resistance) of leptin associated with obesity
10) Confidence 0.50 Published 2010 Journal Peptides Section Abstract Doc Link 19854228 Disease Relevance 0.28 Pain Relevance 0.10
Adipocyte leptin mRNA remained low during the lights-on phase but increased at the onset of the lights-off phase (1900 h) and remained elevated through the dark phase. 4) Hypothalamic leptin-R gene expression, like that of adipocyte leptin gene expression, rose abruptly at the onset of nocturnal feeding behavior but receded progressively to low range thereafter. 5) On the other hand, a dichotomy in the daily rise in adipocyte leptin gene expression and leptin secretion was observed in FF rats.
Positive_regulation (receded) of Gene_expression (expression) of leptin-R in adipocyte
11) Confidence 0.49 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.45 Pain Relevance 0.13
The reasons for the differences between males and females regarding circulating leptin levels and fat accumulation in adult life due to these particular prenatal conditions are not clearly elucidated yet.
Positive_regulation (circulating) of Gene_expression (levels) of leptin in fat
12) Confidence 0.48 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.06 Pain Relevance 0
The reasons for the differences between males and females regarding circulating leptin levels and fat accumulation in adult life due to these particular prenatal conditions are not clearly elucidated yet.
Positive_regulation (accumulation) of Gene_expression (levels) of leptin in fat
13) Confidence 0.48 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.06 Pain Relevance 0
Leptin, produced by adipocytes attenuates the severity of CIP.
Positive_regulation (severity) of Gene_expression (produced) of Leptin in adipocytes associated with pancreatitis and obesity
14) Confidence 0.48 Published 2002 Journal Med. Sci. Monit. Section Abstract Doc Link 11951059 Disease Relevance 0.57 Pain Relevance 0.09
This study demonstrates that direct administration of LS into rat CNS leads to a decrease in body weight of rats and an increase in the expression of leptin in specific areas of the brain and retroperitoneal adipose tissue.



Positive_regulation (increase) of Gene_expression (expression) of leptin in brain associated with body weight and obesity
15) Confidence 0.47 Published 2008 Journal BMC Complement Altern Med Section Abstract Doc Link PMC2263016 Disease Relevance 0.47 Pain Relevance 0.10
production [5] which in turn would lead to increased leptin expression [1].
Positive_regulation (lead) of Gene_expression (expression) of leptin
16) Confidence 0.47 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.45 Pain Relevance 0.13
This reduction was independent of food and water intake and it occurred concomitantly with a strong increase in leptin expression in neurons of the cortical region, thalamus, hypothalamus, and hippocampus.
Positive_regulation (increase) of Gene_expression (expression) of leptin in thalamus associated with hippocampus and thalamus
17) Confidence 0.47 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.30 Pain Relevance 0.16
We employed both immunohistochemistry and in situ hybridization to see whether LS injection leads to leptin overexpression in the brain.
Spec (whether) Positive_regulation (overexpression) of Gene_expression (overexpression) of leptin in brain
18) Confidence 0.47 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.61 Pain Relevance 0.13
This was accompanied by increased leptin expression in CNS, and intestinal and retroperitoneal adipose tissue.


Positive_regulation (increased) of Gene_expression (expression) of leptin in adipose tissue associated with obesity
19) Confidence 0.47 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.56 Pain Relevance 0.04
production [5] which in turn would lead to increased leptin expression [1].
Positive_regulation (increased) of Gene_expression (expression) of leptin
20) Confidence 0.47 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.45 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox