INT82078

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 54
Total Number 55
Disease Relevance 20.47
Pain Relevance 9.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
plasma 7
fat 4
hypothalamus 3
adipose tissue 3
retroperitoneal fat pads 1
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 20 100.00 Very High Very High Very High
anesthesia 36 99.92 Very High Very High Very High
fluoxetine 32 99.84 Very High Very High Very High
qutenza 12 99.60 Very High Very High Very High
Morphine 21 98.60 Very High Very High Very High
Opioid 29 98.52 Very High Very High Very High
medulla 6 98.36 Very High Very High Very High
Serotonin 17 97.98 Very High Very High Very High
Inflammation 69 97.96 Very High Very High Very High
Cholecystokinin 3 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 578 100.00 Very High Very High Very High
Body Weight 262 100.00 Very High Very High Very High
Adrenal Insufficiency 1 99.90 Very High Very High Very High
Nicotine Addiction 1 99.84 Very High Very High Very High
Peripheral Arterial Disease 42 99.62 Very High Very High Very High
Insulin Resistance 50 99.44 Very High Very High Very High
Starvation 13 99.32 Very High Very High Very High
Eating Disorder 13 99.30 Very High Very High Very High
Reprotox - General 2 1 99.04 Very High Very High Very High
Syndrome 5 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the 60th day of fluoxetine treatment, leptin levels were decreased in fluoxetine-treated animals and there was no effect of stress.
Negative_regulation (decreased) of leptin associated with stress and fluoxetine
1) Confidence 0.59 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18423829 Disease Relevance 0.82 Pain Relevance 0.93
Decreased plasma leptin levels in lean and obese Zucker rats after treatment with the serotonin reuptake inhibitor fluoxetine.
Negative_regulation (Decreased) of leptin in plasma associated with obesity, serotonin and fluoxetine
2) Confidence 0.59 Published 1999 Journal Horm. Metab. Res. Section Title Doc Link 10437624 Disease Relevance 0.35 Pain Relevance 0.58
Plasma leptin levels were reduced after both 4 hours and 7 days of fluoxetine administration in lean and after 7 days in fatty rats (all p<0.01).
Negative_regulation (reduced) of leptin in Plasma associated with fluoxetine
3) Confidence 0.59 Published 1999 Journal Horm. Metab. Res. Section Abstract Doc Link 10437624 Disease Relevance 0.34 Pain Relevance 0.60
Significant decreases in serum leptin were observed after laparotomy (8.1 +/- 0.9 versus 3.7 +/- 0.5 microg/L), laparotomy plus ibuprofen treatment (8.9 +/- 1.6 versus 3.1 +/- 0.4 microg/L), and partial hepatectomy plus ibuprofen treatment (5.4 +/- 0.6 versus 3.2 +/- 0.3 microg/L).
Negative_regulation (decreases) of leptin
4) Confidence 0.59 Published 2002 Journal Nutrition Section Body Doc Link 12093446 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Surgical interventions in young rats are accompanied by decreases in serum leptin.
Negative_regulation (decreases) of leptin
5) Confidence 0.59 Published 2002 Journal Nutrition Section Body Doc Link 12093446 Disease Relevance 0 Pain Relevance 0
These acute effects of leptin were impaired in hyperleptinemic animals.
Negative_regulation (impaired) of leptin
6) Confidence 0.58 Published 2010 Journal Peptides Section Abstract Doc Link 19854228 Disease Relevance 0.44 Pain Relevance 0.14
On the other hand, a decrease in leptin receptors mRNA content within hypothalamus and pituitary together with unchanged plasma insulin level may suggest that during rat pregnancy leptin resistance was developed in the hypothalamus, pituitary and pancreatic islets.
Negative_regulation (decrease) of leptin in hypothalamus
7) Confidence 0.54 Published 2006 Journal Reprod Biol Section Abstract Doc Link 16967091 Disease Relevance 0 Pain Relevance 0.13
Thus, the data presented herein may suggest but do not establish the mechanism by which long term exercise decreases leptin levels; whilst increases the response to leptin, contributing to its food-suppressive actions.
Negative_regulation (decreases) of leptin
8) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.15 Pain Relevance 0
We conclude that chronic fluoxetine treatment induced a decreased intake of sweet food, as well as a reduction in leptin levels, and that this result could represent a compensatory response to reduced food intake rather than a direct anorectic mechanism.
Negative_regulation (reduction) of leptin associated with appetite loss and fluoxetine
9) Confidence 0.43 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18423829 Disease Relevance 0.79 Pain Relevance 0.87
We have previously suggested that serotonin may decrease food intake by inhibiting neuropeptide Y neurones, and we further suggest that it also inhibits leptin, possibly by an effect on white adipose tissue.
Spec (possibly) Negative_regulation (inhibits) of leptin in adipose tissue associated with obesity, neuropeptide and serotonin
10) Confidence 0.43 Published 1999 Journal Horm. Metab. Res. Section Abstract Doc Link 10437624 Disease Relevance 0.41 Pain Relevance 0.57
Despite reductions in circulating leptin levels in response to LPS during the neonatal period, no long-term effects on leptin were seen.
Negative_regulation (reductions) of leptin
11) Confidence 0.43 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17507437 Disease Relevance 1.03 Pain Relevance 0.11
RESULTS: Compared with control, the weight gain of pups given a single daily intraperitoneal injection of leptin 0.5 mg/kg, leptin 0.5 mg/kg plus naloxone 0.3 mg/kg, or leptin 0.5 mg/kg plus methylnaltrexone 3.0 mg/kg for 8 consecutive days was significantly reduced (all p < 0.01).
Negative_regulation (injection) of leptin
12) Confidence 0.43 Published 2009 Journal J Opioid Manag Section Body Doc Link 20073411 Disease Relevance 0 Pain Relevance 0
In a neonatal rat model, retroperitoneal fat pad weight decreased significantly in leptin-treated animals, which reduced body weight.
Negative_regulation (decreased) of leptin in body associated with body weight, peripheral arterial disease and opioid
13) Confidence 0.43 Published 2009 Journal J Opioid Manag Section Abstract Doc Link 20073411 Disease Relevance 0.45 Pain Relevance 0.57
Ibuprofen treatment leads to additional decreases in serum leptin concentrations.


Negative_regulation (decreases) of leptin
14) Confidence 0.43 Published 2002 Journal Nutrition Section Body Doc Link 12093446 Disease Relevance 0 Pain Relevance 0
Oral administration of L. plantarum to smokers led to decrease in plasma concentrations of leptin and other parameters which was attributed to anti-inflammatory properties of L. plantarum [15].
Negative_regulation (decrease) of leptin in plasma associated with nicotine addiction and inflammation
15) Confidence 0.43 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.50 Pain Relevance 0.12
In contrast, acute effect of leptin on NO metabolites and cGMP was abolished by triciribine but not by wortmannin.
Negative_regulation (effect) of leptin
16) Confidence 0.43 Published 2010 Journal Peptides Section Abstract Doc Link 19854228 Disease Relevance 0.32 Pain Relevance 0.12
In both control and hyperleptinemic groups the effect of leptin on Na(+) excretion and renal Na(+),K(+)-ATPase was abolished by phosphoinositide 3-kinase (PI3K) inhibitor, wortmannin, but not by protein kinase B/Akt inhibitor, triciribine,.
Negative_regulation (abolished) of leptin
17) Confidence 0.43 Published 2010 Journal Peptides Section Abstract Doc Link 19854228 Disease Relevance 0.41 Pain Relevance 0.13
In the rats, leptin inhibited CCK-8 stimulated protein and trypsin outputs stronger than the basal pancreatic secretion.
Negative_regulation (inhibited) of leptin
18) Confidence 0.42 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12763635 Disease Relevance 0.25 Pain Relevance 0.22
Pancreatic secretory responses to leptin were totally abolished by prior capsaicin deactivation of sensory nerves or by pretreatment of the rats with tarazepide.
Negative_regulation (abolished) of leptin in sensory nerves associated with qutenza
19) Confidence 0.42 Published 2004 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15608360 Disease Relevance 0 Pain Relevance 0.30
The protective and hyperemic effects of centrally administered leptin or CCK-8 (625 ng/rat i.c.v.) were completely abolished by vagotomy and significantly attenuated by sensory denervation with capsaicin or by CGRP antagonist, CGRP(8-37).
Negative_regulation (abolished) of leptin associated with qutenza and antagonist
20) Confidence 0.42 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11787760 Disease Relevance 0.13 Pain Relevance 0.33

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