INT82079

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2011
Negated 0
Speculated 4
Reported most in Body
Documents 79
Total Number 83
Disease Relevance 40.00
Pain Relevance 11.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
plasma 17
fat 7
adipocyte 6
adipose tissue 4
brain 2
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 208 100.00 Very High Very High Very High
cytokine 107 100.00 Very High Very High Very High
Calcitonin gene-related peptide 54 100.00 Very High Very High Very High
chemokine 5 100.00 Very High Very High Very High
substance P 36 99.96 Very High Very High Very High
Central nervous system 12 99.76 Very High Very High Very High
rheumatoid arthritis 29 99.74 Very High Very High Very High
Hippocampus 35 99.72 Very High Very High Very High
agonist 159 99.32 Very High Very High Very High
Pain 8 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 538 100.00 Very High Very High Very High
INFLAMMATION 224 100.00 Very High Very High Very High
Peripheral Arterial Disease 181 100.00 Very High Very High Very High
Hypoxia 174 100.00 Very High Very High Very High
Insulin Resistance 117 100.00 Very High Very High Very High
Pressure And Volume Under Development 47 100.00 Very High Very High Very High
Pancreatitis 37 100.00 Very High Very High Very High
Injury 37 100.00 Very High Very High Very High
Acute Necrotizing Pancreatitis 16 100.00 Very High Very High Very High
Obesity 807 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblotting of protein extracts from intestines and from retroperitoneal adipose tissue from LS-treated and control rats showed only mild increase in both leptin and leptin receptor (data not shown).
Positive_regulation (increase) of leptin in adipose tissue associated with obesity
1) Confidence 0.70 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.31 Pain Relevance 0.12
Chow/preferred-fed rats also had increased circulating leptin levels and decreased growth hormone and 'active' ghrelin levels.
Positive_regulation (increased) of leptin
2) Confidence 0.68 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17443124 Disease Relevance 0.51 Pain Relevance 0.26
CCK (1-100 microg/kg i.p.), given in graded doses, produced a dose-dependent increase in the plasma leptin level and a rise of the expression of ob messenger RNA (mRNA) in gastric mucosa, the maximum being reached at a dose of 100 microg/kg.
Positive_regulation (increase) of leptin in plasma associated with cholecystokinin
3) Confidence 0.67 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10422768 Disease Relevance 0 Pain Relevance 0.57
The data indicated that aging-associated anorexia is caused by an increase in plasma leptin, which results from disturbed reactivity of ghrelin in the hypothalamus and regulation of ghrelin secretion.
Positive_regulation (increase) of leptin in plasma associated with appetite loss and aging
4) Confidence 0.67 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915625 Disease Relevance 0.82 Pain Relevance 0.16
However, naltrexone induced an increase in serum leptin compared with pair-fed controls.
Positive_regulation (increase) of leptin
5) Confidence 0.67 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12069941 Disease Relevance 0.08 Pain Relevance 0.51
In fact, it has been described an increase in leptin levels with age, which seems to be associated to the increased body weigh and fat content [19].
Positive_regulation (increase) of leptin in fat
6) Confidence 0.66 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.66 Pain Relevance 0
Differences in gonadal hormones can account, at least in part, for these differences, since estrogen acts within the brain to increase leptin sensitivity and decrease insulin sensitivity [29].
Positive_regulation (increase) of leptin in brain
7) Confidence 0.66 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.06 Pain Relevance 0
RESULTS: CIP was manifested by an increase in plasma levels of amylase, lipase, leptin and an anti-inflammatory interleukin 10 (IL-10), (by 400%, 1000%, 700% and 50%, respectively), confirmed by histological examination and accompanied by 40% reduction in pancreatic blood flow.
Positive_regulation (increase) of leptin in blood
8) Confidence 0.66 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11951059 Disease Relevance 0.17 Pain Relevance 0
LPS resulted in significant reduction of CIP accompanied by dose-dependent increase in plasma levels of leptin and IL-10.
Positive_regulation (increase) of leptin in plasma
9) Confidence 0.66 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11951059 Disease Relevance 0.14 Pain Relevance 0
Indeed, the mu opioid system in reward-related areas may be inhibited in dietary obesity, probably by increased plasma leptin and insulin, and this may represent a failed homeostatic attempt to limit overeating and eventually obesity.
Positive_regulation (increased) of leptin in plasma associated with hyperphagia, obesity and opioid
10) Confidence 0.65 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384255 Disease Relevance 0.66 Pain Relevance 0.30
Serum leptin levels in the AEP and ANP groups increased after 12 hr and stayed at high levels until 48 hr compared with the control group.
Positive_regulation (increased) of Serum leptin associated with pancreatitis and acute necrotizing pancreatitis
11) Confidence 0.60 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17333355 Disease Relevance 1.64 Pain Relevance 0.15
For the sake of reasoning, assuming that sleep time increased, the probability that leptin was increased is minimal.
Positive_regulation (increased) of leptin
12) Confidence 0.60 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 1.24 Pain Relevance 0.06
In the present experiment, KD rats exhibited increased plasma leptin levels, as compared to CH.
Positive_regulation (increased) of plasma leptin in plasma
13) Confidence 0.57 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2781796 Disease Relevance 0.09 Pain Relevance 0
In contrast, CH controls exhibited a significant increase in plasma leptin levels over time, and ultimately increased to the level of KD:CH leptin by the end of the study.
Positive_regulation (increase) of plasma leptin in plasma
14) Confidence 0.57 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2781796 Disease Relevance 0.06 Pain Relevance 0
OLETF (Otsuka-Long-Evans-Tokushima-Fatty) rats are a selective inbred strain of polygenic variant rats which overeat and develop obesity with elevated leptin levels.
Positive_regulation (elevated) of leptin associated with obesity and sprains and strains
15) Confidence 0.53 Published 2000 Journal Brain Res. Section Abstract Doc Link 10661510 Disease Relevance 0.27 Pain Relevance 0.03
In exercising rats, hypothalamic leptin and insulin responsiveness are increased in an IL-6-dependent manner [5], [6].
Positive_regulation (increased) of leptin
16) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.05 Pain Relevance 0
Naloxone or methylnaltrexone significantly potentiated leptin's effect on body weight (p < 0.05 or p < 0.01, respectively).
Positive_regulation (potentiated) of leptin in body
17) Confidence 0.50 Published 2009 Journal J Opioid Manag Section Body Doc Link 20073411 Disease Relevance 0 Pain Relevance 0
This effect of leptin is enhanced in the presence of cholecystokinin (CCK).
Positive_regulation (enhanced) of leptin associated with cholecystokinin
18) Confidence 0.50 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16192299 Disease Relevance 0 Pain Relevance 0.30
Circulating leptin correlated well with fat mass and increased more after vasoconstrictor infusion in NR sheep.
Positive_regulation (Circulating) of leptin in fat
19) Confidence 0.48 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14975924 Disease Relevance 0.26 Pain Relevance 0.12
Unlike males, CR females did not display significant changes in circulating leptin levels compared with their controls.
Positive_regulation (circulating) of leptin
20) Confidence 0.48 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.53 Pain Relevance 0

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