INT82080

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Context Info
Confidence 0.45
First Reported 1999
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.36
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
plasma 2
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 8 100.00 Very High Very High Very High
cytokine 2 88.00 High High
ketamine 2 85.72 High High
withdrawal 2 76.92 Quite High
Neuropeptide 5 75.00 Quite High
Opioid 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 12 100.00 Very High Very High Very High
Cancer 4 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Hemorrhage 4 98.24 Very High Very High Very High
Body Weight 2 83.24 Quite High
Eating Disorder 8 81.32 Quite High
Weight Gain 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that release of TNF-alpha, [NO3/NO2], and leptin are neurally controlled since plasma levels of all three declined as a result of anesthesia.
Regulation (controlled) of Localization (release) of leptin in plasma associated with anesthesia
1) Confidence 0.45 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 11368420 Disease Relevance 0.42 Pain Relevance 0.35
Comparisons of the effects of anesthesia and stress on release of tumor necrosis factor-alpha, leptin, and nitric oxide in adult male rats.
Regulation (effects) of Localization (release) of leptin associated with stress, necrosis, anesthesia and cancer
2) Confidence 0.45 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 11368420 Disease Relevance 0.58 Pain Relevance 0.37
Thus, it may be important to consider the daily patterns of gene expression and availability of hypothalamic orexigenic peptides in investigations aimed at elucidating the central mechanisms underlying the feedback action of the normal and altered leptin secretion patterns.
Regulation (altered) of Localization (secretion) of leptin
3) Confidence 0.44 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.36 Pain Relevance 0.04

General Comments

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