INT82080

Context Info Confidence 0.45 First Reported 1999 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 1.36 Pain Relevance 0.76

extracellular space (Lep) extracellular region (Lep) intracellular (Lep) lipid metabolic process (Lep)

Anatomy Link Frequency plasma 2 Lep (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 8 100.00 cytokine 2 88.00 ketamine 2 85.72 withdrawal 2 76.92 Neuropeptide 5 75.00 Opioid 1 25.00

Disease Link Frequency Relevance Heat Stress 12 100.00 Cancer 4 100.00 Necrosis 4 100.00 Hemorrhage 4 98.24 Body Weight 2 83.24 Eating Disorder 8 81.32 Weight Gain 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We conclude that release of TNF-alpha, [NO3/NO2], and leptin are neurally controlled since plasma levels of all three declined as a result of anesthesia.

Regulation (controlled) of Localization (release) of leptin in plasma associated with anesthesia

1) Confidence 0.45 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 11368420 Disease Relevance 0.42 Pain Relevance 0.35

Comparisons of the effects of anesthesia and stress on release of tumor necrosis factor-alpha, leptin, and nitric oxide in adult male rats.

Regulation (effects) of Localization (release) of leptin associated with stress, necrosis, anesthesia and cancer

2) Confidence 0.45 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 11368420 Disease Relevance 0.58 Pain Relevance 0.37

Thus, it may be important to consider the daily patterns of gene expression and availability of hypothalamic orexigenic peptides in investigations aimed at elucidating the central mechanisms underlying the feedback action of the normal and altered leptin secretion patterns.

Regulation (altered) of Localization (secretion) of leptin

3) Confidence 0.44 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.36 Pain Relevance 0.04

General Comments

This test has worked.