INT82081

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Context Info
Confidence 0.53
First Reported 1999
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 7.78
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
adipocytes 4
WAT 2
third ventricle 2
body 2
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 42 100.00 Very High Very High Very High
Neuropeptide 6 100.00 Very High Very High Very High
bDMF 76 99.36 Very High Very High Very High
Serotonin 14 98.04 Very High Very High Very High
Inflammation 53 97.52 Very High Very High Very High
Inflammatory mediators 5 94.72 High High
agonist 3 94.56 High High
depression 14 92.88 High High
dexamethasone 1 90.80 High High
Opioid 1 87.64 High High
Disease Link Frequency Relevance Heat
Obesity 202 100.00 Very High Very High Very High
Body Weight 88 100.00 Very High Very High Very High
Diabetes Mellitus 63 99.04 Very High Very High Very High
INFLAMMATION 69 97.52 Very High Very High Very High
Insulin Resistance 28 96.52 Very High Very High Very High
Stress 49 94.28 High High
Wound Healing 12 93.92 High High
Eating Disorder 8 93.12 High High
Depression 22 92.88 High High
Metabolic Syndrome 50 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is necessary, therefore, that leptin levels are measured to control for this confounding factor and to elucidate the effect of sleep fragmentation on leptin production.
Regulation (effect) of Gene_expression (production) of leptin
1) Confidence 0.53 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 1.10 Pain Relevance 0.03
To see whether the effect on leptin synthesis was specific we also performed immunohistochemistry for GM-CSF and TNF?
Spec (whether) Regulation (effect) of Gene_expression (synthesis) of leptin
2) Confidence 0.45 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.30 Pain Relevance 0.11
They ascribed this to regulation of leptin synthesis by IL1?
Regulation (regulation) of Gene_expression (synthesis) of leptin
3) Confidence 0.45 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.52 Pain Relevance 0.13
To further understand the interplay between the central appetite-stimulating- and peripheral appetite-inhibiting signals in the management of daily food intake, we have examined the daily patterns in expression of the hypothalamic neuropeptides and leptin receptor (R) and adipocyte leptin gene expression and secretion in freely feeding (FF) rats.
Regulation (secretion) of Gene_expression (expression) of leptin in adipocyte associated with neuropeptide
4) Confidence 0.44 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.35 Pain Relevance 0.22
A key hormone regulating food-intake behavior is leptin, the product of the ob gene [27].
Regulation (regulating) of Gene_expression (product) of leptin associated with obesity
5) Confidence 0.37 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1090442 Disease Relevance 0.78 Pain Relevance 0.49
Insulinemia and leptinemia were not altered by third ventricle microinjection of leptin (data not shown).


Neg (not) Regulation (altered) of Gene_expression (microinjection) of leptin in third ventricle
6) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.08 Pain Relevance 0.05
A key hormone regulating food-intake behavior is leptin, the product of the ob gene [27].
Regulation (regulating) of Gene_expression (product) of ob associated with obesity
7) Confidence 0.33 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1090442 Disease Relevance 0.79 Pain Relevance 0.49
Effect of Lactobacillus acidophilus supernatants on body weight and leptin expression in rats

Background

Regulation (Effect) of Gene_expression (expression) of leptin in body associated with body weight
8) Confidence 0.27 Published 2008 Journal BMC Complement Altern Med Section Title Doc Link PMC2263016 Disease Relevance 0.34 Pain Relevance 0.11
In vitro analysis, using isolated rat adipocytes incubated with MEL (1 nM) and INS, did not affect LEP expression when administered alone, whereas administered together they have increased it by 120%.
Neg (not) Regulation (affect) of Gene_expression (expression) of LEP in adipocytes associated with obesity
9) Confidence 0.20 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.50 Pain Relevance 0.05
There was no significant change in the mean value of serum leptin, IL-6 and TNF-?
Neg (no) Regulation (change) of Gene_expression (value) of serum leptin
10) Confidence 0.16 Published 2010 Journal Crit Care Section Body Doc Link PMC2887140 Disease Relevance 1.18 Pain Relevance 0
These include CRP, an important protein in leptin action (Chen et al 2006), and TNF?
Regulation (important) of Gene_expression (action) of leptin
11) Confidence 0.08 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291335 Disease Relevance 0.79 Pain Relevance 0.08
This cytokine is involved in metabolic, physiological and immunological regulation in this tissue and plays a pivotal role in the production of several other cytokines (e.g., IL-10) and adipokines in WAT, such as leptin [4,5].
Regulation (role) of Gene_expression (production) of leptin in WAT associated with obesity and cytokine
12) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 1.04 Pain Relevance 0.37

General Comments

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