INT82082

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Context Info
Confidence 0.81
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 63
Total Number 64
Disease Relevance 26.41
Pain Relevance 8.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
adipocyte 9
adipose tissue 7
pituitary 4
stomach 3
plasma 2
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 46 99.80 Very High Very High Very High
qutenza 36 99.80 Very High Very High Very High
Cholecystokinin 29 99.32 Very High Very High Very High
Neuropeptide 88 99.04 Very High Very High Very High
Inflammation 445 98.96 Very High Very High Very High
aspirin 21 98.84 Very High Very High Very High
Pain 17 98.54 Very High Very High Very High
cytokine 299 98.44 Very High Very High Very High
Inflammatory mediators 17 98.08 Very High Very High Very High
Hippocampus 61 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 531 100.00 Very High Very High Very High
Cancer 283 100.00 Very High Very High Very High
Necrosis 50 100.00 Very High Very High Very High
Stress 652 99.92 Very High Very High Very High
Sepsis 118 99.76 Very High Very High Very High
Insulin Resistance 60 99.50 Very High Very High Very High
Eating Disorder 92 99.48 Very High Very High Very High
INFLAMMATION 490 98.96 Very High Very High Very High
Ulcers 28 98.94 Very High Very High Very High
Pain 24 98.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because gastric mucosal leptin is secreted in response to ingestion of a meal, we hypothesized that it might contribute to satiation (meal termination) by acting on gastrointestinal vagal afferent neurons.
Localization (secreted) of leptin in afferent neurons
1) Confidence 0.81 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15591156 Disease Relevance 0.10 Pain Relevance 0
Leptin is a hormone secreted into the systemic blood primarily by white adipose tissue.
Localization (secreted) of Leptin in adipose tissue associated with obesity
2) Confidence 0.81 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15591156 Disease Relevance 0.10 Pain Relevance 0
Because we presumed that pain and inflammation would influence food intake and subsequent leptin release, laparotomized and partially hepatectomized rats were treated with ibuprofen.
Localization (release) of leptin associated with pain and inflammation
3) Confidence 0.81 Published 2002 Journal Nutrition Section Abstract Doc Link 12093446 Disease Relevance 0.20 Pain Relevance 0.15
Bleau et al. [1] described Lactobacillus-induced decrease in leptin release by adipocyte derived from SJL mice, whereas the same Lactobacillus preparation led to an increase in leptin release when used to treat C57BL/6 adipocytes.
Localization (release) of leptin in adipocytes associated with obesity
4) Confidence 0.81 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.40 Pain Relevance 0.12
Bleau et al. [1] described Lactobacillus-induced decrease in leptin release by adipocyte derived from SJL mice, whereas the same Lactobacillus preparation led to an increase in leptin release when used to treat C57BL/6 adipocytes.
Localization (release) of leptin in adipocytes associated with obesity
5) Confidence 0.81 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.46 Pain Relevance 0.10
Apart from controlling energy balance, leptin, secreted by adipose tissue, is also involved in the regulation of cardiovascular function.
Localization (secreted) of leptin in adipose tissue associated with obesity
6) Confidence 0.80 Published 2010 Journal Peptides Section Abstract Doc Link 19854228 Disease Relevance 0.47 Pain Relevance 0
It was recently reported that leptin, released into the gut lumen during the cephalic phase of gastric secretion, is capable of initiating intestinal nutrient absorption.
Localization (released) of leptin in lumen
7) Confidence 0.80 Published 2007 Journal Physiol Res Section Abstract Doc Link 16792473 Disease Relevance 0.10 Pain Relevance 0.07
Leptin is also produced in the stomach and released into the gastrointestinal lumen but the implication of luminal leptin in the regulation of pancreatic enzyme secretion has not been elucidated.
Localization (released) of Leptin in lumen
8) Confidence 0.80 Published 2004 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15608360 Disease Relevance 0.09 Pain Relevance 0.03
Leptin, 16- kDa protein produced and secreted from white adipocytes is known to regulate food intake and energy expenditure.
Localization (secreted) of Leptin in adipocytes associated with obesity
9) Confidence 0.80 Published 2004 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15608360 Disease Relevance 0.10 Pain Relevance 0
Comparisons of the effects of anesthesia and stress on release of tumor necrosis factor-alpha, leptin, and nitric oxide in adult male rats.
Localization (release) of leptin associated with stress, necrosis, anesthesia and cancer
10) Confidence 0.80 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 11368420 Disease Relevance 0.58 Pain Relevance 0.37
Bacterial lipopolysaccharide (LPS) stimulates massive release of tumor necrosis factor-alpha (TNF-alpha) together with nitric oxide (NO) and a lessor release of leptin.
Localization (release) of leptin associated with necrosis and cancer
11) Confidence 0.80 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 11368420 Disease Relevance 0.52 Pain Relevance 0.31
Leptin, a product of ob gene controlling food intake, has recently been detected in the stomach and shown to be released by CCK and implicated in gastroprotection against various noxious agents but it is unknown whether centrally applied leptin influences ischemia-reperfusion (I/R)-induced gastric erosions that progress into deeper gastric ulcerations.
Localization (released) of Leptin in stomach associated with ischemia and obesity
12) Confidence 0.79 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11787760 Disease Relevance 0.27 Pain Relevance 0.12
Adipocyte leptin mRNA remained low during the lights-on phase but increased at the onset of the lights-off phase (1900 h) and remained elevated through the dark phase. 4) Hypothalamic leptin-R gene expression, like that of adipocyte leptin gene expression, rose abruptly at the onset of nocturnal feeding behavior but receded progressively to low range thereafter. 5) On the other hand, a dichotomy in the daily rise in adipocyte leptin gene expression and leptin secretion was observed in FF rats.
Localization (secretion) of leptin in adipocyte
13) Confidence 0.79 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.44 Pain Relevance 0.11
Thus, it may be important to consider the daily patterns of gene expression and availability of hypothalamic orexigenic peptides in investigations aimed at elucidating the central mechanisms underlying the feedback action of the normal and altered leptin secretion patterns.
Localization (secretion) of leptin
14) Confidence 0.79 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.36 Pain Relevance 0.04
Overall, these results show that in FF rats, gene expression of hypothalamic appetite stimulating peptides first rise and then fall to nadir during the lights-on phase when leptin levels are in low range; adipocyte leptin mRNA rises before impending ingestive behavior and increased leptin secretion reaching peak manifests itself during nocturnal feeding.
Localization (secretion) of leptin in adipocyte
15) Confidence 0.79 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.43 Pain Relevance 0.06
The FR regimen, which curtailed the normal body weight gain, abolished these daily fluctuations in gene expression of hypothalamic orexigenic peptides and adipocyte leptin but permitted feeding-associated increased leptin secretion.
Localization (secretion) of leptin in adipocyte associated with body weight and eating disorder
16) Confidence 0.79 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.41 Pain Relevance 0.04
In conclusion, exogenous leptin can modulate exocrine pancreatic secretion through mechanisms involving CCK(1) receptors and capsaicin-sensitive afferent fibres in the rat.
Localization (secretion) of leptin associated with qutenza
17) Confidence 0.78 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12106809 Disease Relevance 0 Pain Relevance 0.34
Leptin, secreted by adipose tissue, is involved in the pathogenesis of arterial hypertension, however, the mechanisms through which leptin increases blood pressure are incompletely elucidated.
Localization (secreted) of Leptin in blood associated with pressure and volume under development and obesity
18) Confidence 0.78 Published 2005 Journal Acta Biochim. Pol. Section Abstract Doc Link 16082415 Disease Relevance 0.20 Pain Relevance 0.10
We conclude that: (1) exogenous leptin or that released endogenously by CCK or meal exerts a potent gastroprotective action depending upon vagal activity, and involving hyperemia probably mediated by NO and sensory nerves but unrelated to endogenous prostaglandins; (2) leptin mimics the gastroprotective effect of CCK and probably mediates the protective and hyperemic actions of CCK in the rat stomach.
Localization (released) of leptin in stomach associated with increased venous pressure under development and cholecystokinin
19) Confidence 0.78 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10422768 Disease Relevance 0.18 Pain Relevance 0.42
CONCLUSIONS: Pretreatment with LPS given i.c.v. prevents the development of caerulein-induced pancreatitis through the activation of SN and though the release of leptin.


Localization (release) of leptin
20) Confidence 0.76 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11951059 Disease Relevance 0.11 Pain Relevance 0

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