INT82083

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Context Info
Confidence 0.56
First Reported 1999
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 8.07
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
adipose tissue 4
adipocytes 4
plasma 2
fat 2
sympathetic nervous system 2
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 75 99.98 Very High Very High Very High
fluoxetine 10 98.68 Very High Very High Very High
anesthesia 11 87.76 High High
Eae 1 82.80 Quite High
tolerance 26 81.36 Quite High
Inflammation 59 78.28 Quite High
Neuropeptide 12 75.00 Quite High
Serotonin 12 67.00 Quite High
Central nervous system 3 63.72 Quite High
antidepressant 3 55.52 Quite High
Disease Link Frequency Relevance Heat
Body Weight 134 99.86 Very High Very High Very High
Peripheral Arterial Disease 15 99.70 Very High Very High Very High
Obesity 220 99.58 Very High Very High Very High
Starvation 13 99.32 Very High Very High Very High
Metabolic Syndrome 44 99.04 Very High Very High Very High
Eating Disorder 15 98.90 Very High Very High Very High
Sleep Disorders 25 98.42 Very High Very High Very High
Insulin Resistance 49 96.16 Very High Very High Very High
Stress 113 95.88 Very High Very High Very High
Appetite Loss 20 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, other studies based on postnatal dietary manipulations, such as cafeteria diet exposure [30] or HF diet exposure [31] have shown that male rats, but not females, exhibited decreased hypothalamic expression levels of leptin receptor compared with their controls under standard diet, suggesting central leptin resistance.
Negative_regulation (decreased) of Gene_expression (expression) of leptin
1) Confidence 0.56 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.14 Pain Relevance 0
Moreover, decreased expression of leptin receptor has also been observed in internal white adipose tissue depots of male rats exposed to HF diet, but not in females [32].
Negative_regulation (decreased) of Gene_expression (expression) of leptin in adipose tissue associated with obesity
2) Confidence 0.56 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.17 Pain Relevance 0
We conclude that chronic fluoxetine treatment induced a decreased intake of sweet food, as well as a reduction in leptin levels, and that this result could represent a compensatory response to reduced food intake rather than a direct anorectic mechanism.
Negative_regulation (reduction) of Gene_expression (levels) of leptin associated with appetite loss and fluoxetine
3) Confidence 0.43 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18423829 Disease Relevance 0.79 Pain Relevance 0.87
The FR regimen, which curtailed the normal body weight gain, abolished these daily fluctuations in gene expression of hypothalamic orexigenic peptides and adipocyte leptin but permitted feeding-associated increased leptin secretion.
Negative_regulation (abolished) of Gene_expression (expression) of leptin in adipocyte associated with body weight and eating disorder
4) Confidence 0.42 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.43 Pain Relevance 0.04
Moreover, CR animals also showed diminished mRNA expression levels of the long form of the leptin receptor at weaning [12] suggesting a predisposition to leptin resistance.
Negative_regulation (diminished) of Gene_expression (expression) of leptin
5) Confidence 0.41 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.34 Pain Relevance 0.03
Since leptin is synthesized and secreted from white adipose tissue, it is not surprising to find the significantly reduced leptin levels in Phyto-600 animals compared to Phyto-free group.
Negative_regulation (reduced) of Gene_expression (levels) of leptin in adipose tissue associated with obesity
6) Confidence 0.36 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1276816 Disease Relevance 0.69 Pain Relevance 0.04
Determination of plasma leptin levels
Negative_regulation (Determination) of Gene_expression (levels) of leptin in plasma
7) Confidence 0.35 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1090442 Disease Relevance 0.28 Pain Relevance 0.17
They reported significantly higher serum leptin levels of 31.3 ± 24.1?
Negative_regulation (reported) of Gene_expression (levels) of serum leptin
8) Confidence 0.35 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.80 Pain Relevance 0.03
They also found a large increase in small adipocyte recruitment in the retroperitoneal fat pad, as well as a suppression of leptin expression in mature adipocytes.
Negative_regulation (suppression) of Gene_expression (expression) of leptin in adipocytes associated with obesity and peripheral arterial disease
9) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794370 Disease Relevance 1.66 Pain Relevance 0.08
Male ob/ob mice, a genetic model of impaired LEP production that results in severe obesity along with symptoms of metabolic dysregulation, showed sleep fragmentation and the elevated number of arousals from sleep [50].
Negative_regulation (impaired) of Gene_expression (production) of LEP associated with obesity and metabolic syndrome
10) Confidence 0.22 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.65 Pain Relevance 0.04
Feeding rats a high-fat diet containing Enalapril also significantly reduced serum insulin levels and leptin levels (but not significantly) compared to high-fat fed rats.
Negative_regulation (reduced) of Gene_expression (levels) of leptin in fat
11) Confidence 0.22 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 0.41 Pain Relevance 0.07
agonists inhibit the expression and function of leptin [24,25].
Negative_regulation (inhibit) of Gene_expression (expression) of leptin associated with agonist
12) Confidence 0.20 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.54 Pain Relevance 0.38
Sleep deprivation also leads to changes in the activation of the sympathetic nervous system, to reduced levels of leptin and to increased levels of ghrelin in the general circulation [13].
Negative_regulation (reduced) of Gene_expression (levels) of leptin in sympathetic nervous system associated with sleep disorders
13) Confidence 0.16 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2842885 Disease Relevance 0.80 Pain Relevance 0
Thus, in case leptin levels decrease, such as during starvation, the opposite is expected to occur: a rise in GH output and sensitivity to GHRH.
Negative_regulation (decrease) of Gene_expression (levels) of leptin associated with starvation
14) Confidence 0.11 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.38 Pain Relevance 0

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