INT82084

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.65
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
adipocyte 6
hepatocytes 2
pituitary 2
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 1 96.96 Very High Very High Very High
cytokine 32 92.48 High High
ketamine 3 87.92 High High
bDMF 38 85.88 High High
anesthesia 11 85.44 High High
Serotonin 12 84.56 Quite High
Neuropeptide 17 82.72 Quite High
Inflammation 63 81.92 Quite High
depression 8 79.40 Quite High
antidepressant 2 70.48 Quite High
Disease Link Frequency Relevance Heat
Cancer 38 100.00 Very High Very High Very High
Necrosis 8 100.00 Very High Very High Very High
Obesity 84 98.88 Very High Very High Very High
Body Weight 52 97.64 Very High Very High Very High
Stress 76 96.96 Very High Very High Very High
Aids-related Complex 23 96.08 Very High Very High Very High
Eating Disorder 20 96.02 Very High Very High Very High
Sleep Initiation And Maintenance Disorders 2 92.88 High High
Sprains And Strains 3 91.88 High High
Hyperphagia 8 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bleau et al. [1] described Lactobacillus-induced decrease in leptin release by adipocyte derived from SJL mice, whereas the same Lactobacillus preparation led to an increase in leptin release when used to treat C57BL/6 adipocytes.
Positive_regulation (increase) of Localization (release) of leptin in adipocytes associated with obesity
1) Confidence 0.70 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.46 Pain Relevance 0.10
Bacterial lipopolysaccharide (LPS) stimulates massive release of tumor necrosis factor-alpha (TNF-alpha) together with nitric oxide (NO) and a lessor release of leptin.
Positive_regulation (stimulates) of Localization (release) of leptin associated with necrosis and cancer
2) Confidence 0.69 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 11368420 Disease Relevance 0.52 Pain Relevance 0.31
The FR regimen, which curtailed the normal body weight gain, abolished these daily fluctuations in gene expression of hypothalamic orexigenic peptides and adipocyte leptin but permitted feeding-associated increased leptin secretion.
Positive_regulation (increased) of Localization (secretion) of leptin in adipocyte associated with body weight and eating disorder
3) Confidence 0.68 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.41 Pain Relevance 0.04
Overall, these results show that in FF rats, gene expression of hypothalamic appetite stimulating peptides first rise and then fall to nadir during the lights-on phase when leptin levels are in low range; adipocyte leptin mRNA rises before impending ingestive behavior and increased leptin secretion reaching peak manifests itself during nocturnal feeding.
Positive_regulation (increased) of Localization (secretion) of leptin in adipocyte
4) Confidence 0.68 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.43 Pain Relevance 0.06
CONCLUSIONS: Pretreatment with LPS given i.c.v. prevents the development of caerulein-induced pancreatitis through the activation of SN and though the release of leptin.


Positive_regulation (activation) of Localization (release) of leptin
5) Confidence 0.48 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11951059 Disease Relevance 0.11 Pain Relevance 0
Finally, the direct effect of leptin was assessed in C3A hepatocytes treated with leptin for 24 hours (7.8?
Positive_regulation (hepatocytes) of Localization (treated) of leptin in hepatocytes
6) Confidence 0.41 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2817554 Disease Relevance 0.42 Pain Relevance 0.08
For example, leptin secretion increases but hypothalamic resistance to leptin actions develops.
Positive_regulation (increases) of Localization (secretion) of leptin
7) Confidence 0.41 Published 2007 Journal Physiol. Behav. Section Abstract Doc Link 17512024 Disease Relevance 0.42 Pain Relevance 0.04
Recent evidence indicates that glucocorticoids induce leptin synthesis and secretion and that, conversely, leptin participates in the regulation of HPA axis function [29].
Positive_regulation (induce) of Localization (secretion) of leptin
8) Confidence 0.38 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1090442 Disease Relevance 0.72 Pain Relevance 0.38
However, when added simultaneously with MEL, LEP release was increased by a robust 250% [44].
Positive_regulation (increased) of Localization (release) of LEP
9) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.92 Pain Relevance 0.08
Under our experimental conditions, leptin (intraperitoneally) did not change the acetylation state of either protein, suggesting that the fasting induced decrease in FoxO1 acetylation was leptin-independent.
Positive_regulation (induced) of Localization (decrease) of leptin
10) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.24 Pain Relevance 0
Interestingly, there may be a connection between leptin and the NO system, described above, as leptin-induced LH release from isolated pituitary appears to be mediated by NO, with the effect being most pronounced in pituitary from pro-oestrous female rats (537, 538).
Neg (NO) Positive_regulation (mediated) of Localization (release) of leptin-induced in pituitary
11) Confidence 0.12 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.03

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