INT8210

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Context Info
Confidence 0.68
First Reported 1988
Last Reported 2011
Negated 11
Speculated 8
Reported most in Body
Documents 188
Total Number 196
Disease Relevance 146.57
Pain Relevance 12.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 22
skeletal muscle 11
blood 10
liver 10
adipose tissue 9
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Acute pain 9 99.98 Very High Very High Very High
withdrawal 15 99.92 Very High Very High Very High
tolerance 432 99.90 Very High Very High Very High
Inflammation 1534 99.84 Very High Very High Very High
Pain 431 99.78 Very High Very High Very High
depression 184 99.28 Very High Very High Very High
rheumatoid arthritis 81 99.16 Very High Very High Very High
qutenza 7 98.96 Very High Very High Very High
Opioid 9 98.74 Very High Very High Very High
beta blocker 6 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 9721 100.00 Very High Very High Very High
Obesity 2677 100.00 Very High Very High Very High
Insulin Resistance 1625 100.00 Very High Very High Very High
Metabolic Syndrome 754 100.00 Very High Very High Very High
Hyperglycemia 634 100.00 Very High Very High Very High
Polycystic Ovary Syndrome 399 100.00 Very High Very High Very High
Infection 307 100.00 Very High Very High Very High
Hyperinsulinism 292 100.00 Very High Very High Very High
Targeted Disruption 86 100.00 Very High Very High Very High
Anaemia 50 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Semi-quantitative RT-PCR measures of insulin mRNA expression showed that exposure of cultures grown in 5 mM glucose at stage 3 to 17 mM glucose at stage 4 induced insulin expression (Figure 3A).
Positive_regulation (induced) of Gene_expression (expression) of insulin in stage 4
1) Confidence 0.68 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.26 Pain Relevance 0
-cell differentiation and expansion in vivo and in utero [20], so we tested whether exposure of stage 3 cells to elevated glucose levels could induce insulin expression.
Positive_regulation (induce) of Gene_expression (expression) of insulin in stage 3
2) Confidence 0.68 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.17 Pain Relevance 0
This is accompanied by increased insulin synthesis resulting in hyperinsulinemia which is thought to be a compensatory response to reduced insulin sensitivity.
Positive_regulation (increased) of Gene_expression (synthesis) of insulin associated with hyperinsulinism
3) Confidence 0.68 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1868084 Disease Relevance 1.77 Pain Relevance 0.05
Endogenous glucose production during insulin stimulation was increased only in the glucose group after surgery (P < 0.05 versus before).
Positive_regulation (increased) of Gene_expression (production) of insulin
4) Confidence 0.66 Published 2006 Journal Nutrition Section Body Doc Link 16473497 Disease Relevance 0.06 Pain Relevance 0
The so-named “incretin effect” has been demonstrated for years, and refers to the fact that an oral glucose load will stimulate insulin production to a greater degree than will glucose administered intravenously.
Positive_regulation (stimulate) of Gene_expression (production) of insulin
5) Confidence 0.61 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597758 Disease Relevance 0.47 Pain Relevance 0
Attempts to overcome these problems have been made by other companies that are developing their own versions of inhaled insulin and promising results regarding patients’ acceptance are beginning to emerge.13
Positive_regulation (versions) of Gene_expression (versions) of insulin
6) Confidence 0.50 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2915552 Disease Relevance 0.29 Pain Relevance 0
Importance of insulin therapy
Positive_regulation (Importance) of Gene_expression (therapy) of insulin
7) Confidence 0.50 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994047 Disease Relevance 0.58 Pain Relevance 0
Further, the maximal and overall metabolic effects of all three insulin formulations were comparable at the same dose level, showing that when human insulin is mixed with ingredients that lead the insulin molecule to maintain the monomeric state and simultaneously mask charges on its surface, an improvement in insulin absorption and action is achieved.
Positive_regulation (improvement) of Gene_expression (absorption) of insulin
8) Confidence 0.50 Published 2008 Journal Diabetologia Section Body Doc Link PMC2516197 Disease Relevance 0.25 Pain Relevance 0.16
Glycemic control in adults: insulin glargine versus NPH insulin
Positive_regulation (adults) of Gene_expression (versus) of NPH insulin
9) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.47 Pain Relevance 0
Glycemic control in adults: insulin glargine versus NPH insulin
Positive_regulation (versus) of Gene_expression (glargine) of NPH insulin
10) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.47 Pain Relevance 0
The results from six of these large controlled trials (level 2 evidence) comparing subcutaneous insulin glargine with subcutaneous NPH insulin show that over a period of up to 1 year, both insulin glargine and NPH insulin produced clinically significant improvements in glycemic control with some trials reporting high response rates.
Positive_regulation (improvements) of Gene_expression (produced) of NPH insulin
11) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.08 Pain Relevance 0
This trial assessed the “early” introduction of insulin glargine in 405 patients with type 2 diabetes with an HbA1c of ?
Positive_regulation (introduction) of Gene_expression (glargine) of insulin associated with diabetes mellitus
12) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.57 Pain Relevance 0
Glycemic control in adults: insulin glargine versus NPH insulin
Positive_regulation (versus) of Gene_expression (versus) of insulin
13) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.31 Pain Relevance 0
Glycemic control in adults: insulin glargine versus NPH insulin
Positive_regulation (versus) of Gene_expression (glargine) of insulin
14) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.31 Pain Relevance 0
Glycemic control in adults: insulin glargine versus NPH insulin
Positive_regulation (versus) of Gene_expression (versus) of NPH insulin
15) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.31 Pain Relevance 0
1.24) than with either NPH insulin (?
Positive_regulation (than) of Gene_expression (with) of NPH insulin
16) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0 Pain Relevance 0
Glycemic control in adults: insulin glargine versus NPH insulin
Positive_regulation (adults) of Gene_expression (versus) of insulin
17) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.31 Pain Relevance 0
Glycemic control in adults: insulin glargine versus NPH insulin
Positive_regulation (versus) of Gene_expression (versus) of NPH insulin
18) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.47 Pain Relevance 0
Glycemic control in adults: insulin glargine versus NPH insulin
Positive_regulation (versus) of Gene_expression (versus) of insulin
19) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.47 Pain Relevance 0
Glycemic control in adults: insulin glargine versus NPH insulin
Positive_regulation (versus) of Gene_expression (glargine) of insulin
20) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.47 Pain Relevance 0

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