INT82104

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Context Info
Confidence 0.54
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 4.78
Pain Relevance 6.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gimap1)
Anatomy Link Frequency
IAN 18
inferior 2
capsules 1
peripheral nerve 1
lip 1
Gimap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
inferior alveolar nerve 535 100.00 Very High Very High Very High
c fibre 21 99.70 Very High Very High Very High
lidocaine 13 99.44 Very High Very High Very High
pulpitis 32 98.76 Very High Very High Very High
Neuronal excitability 12 97.28 Very High Very High Very High
anesthesia 24 97.00 Very High Very High Very High
Pain 39 96.12 Very High Very High Very High
trigeminal ganglion 198 91.48 High High
dorsal root ganglion 9 72.48 Quite High
Nerve growth factor 12 71.12 Quite High
Disease Link Frequency Relevance Heat
Pulpitis 32 98.76 Very High Very High Very High
Hypesthesia 4 98.56 Very High Very High Very High
Pain 42 96.12 Very High Very High Very High
Emergencies 4 95.00 High High
Sleep Disorders 4 94.16 High High
Ganglion Cysts 207 91.48 High High
Nervous System Injury 51 80.00 Quite High
Infection 3 74.16 Quite High
Neuropathic Pain 24 65.08 Quite High
Congenital Anomalies 6 48.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For mandibular posterior teeth, triazolam in a sublingual dose of 0.25 mg did not result in an increase in success of the IAN block in patients with irreversible pulpitis.
Negative_regulation (block) of IAN in IAN associated with inferior alveolar nerve and pulpitis
1) Confidence 0.54 Published 2008 Journal J Endod Section Abstract Doc Link 18793913 Disease Relevance 0.65 Pain Relevance 0.94
METHODS: Seventy-three blinded adult subjects randomly received buccal infiltrations at the first molar site with a cartridge of 4 percent articaine with 1:100,000 epinephrine at one appointment and a cartridge of 2 percent lidocaine with 1:100,000 epinephrine at another appointment after receiving a standard IAN block with the use of 4 percent articaine with 1:100,000 epinephrine in a crossover design.
Negative_regulation (block) of IAN in IAN
2) Confidence 0.47 Published 2008 Journal J Am Dent Assoc Section Body Doc Link 18762633 Disease Relevance 0 Pain Relevance 0
CONCLUSION AND CLINICAL IMPLICATIONS: For a mandibular buccal infiltration of the first molar after a standard IAN block, 4 percent articaine with 1:100,000 epinephrine resulted in a higher success rate (88 percent) than did 2 percent lidocaine with 1:100,000 epinephrine (71 percent success rate).


Negative_regulation (block) of IAN in IAN
3) Confidence 0.47 Published 2008 Journal J Am Dent Assoc Section Body Doc Link 18762633 Disease Relevance 0 Pain Relevance 0
CONCLUSION: In conclusion, 57% to 89% of patients presenting with irreversible pulpitis have the potential for moderate to severe pain with the IAN block.


Negative_regulation (block) of IAN in IAN
4) Confidence 0.40 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 17706440 Disease Relevance 0.06 Pain Relevance 0
RESULTS: Moderate-to-severe pain may occur 57% to 89% of the time with the IAN block.
Negative_regulation (block) of IAN in IAN
5) Confidence 0.40 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 17706440 Disease Relevance 0.09 Pain Relevance 0
CONCLUSIONS: We concluded that the IAN block administered with a peripheral nerve stimulator did not increase the success rate of pulpal anesthesia when compared with a conventional IAN block.


Negative_regulation (block) of IAN in IAN
6) Confidence 0.40 Published 2010 Journal J Endod Section Body Doc Link 20171357 Disease Relevance 0 Pain Relevance 0
Access was begun 15 minutes after completion of the IAN block, and all patients had profound lip numbness.
Negative_regulation (block) of IAN in lip
7) Confidence 0.40 Published 2010 Journal J Endod Section Body Doc Link 20171351 Disease Relevance 0.09 Pain Relevance 0
Fifty-eight emergency patients diagnosed with irreversible pulpitis of a mandibular posterior tooth randomly received, in a double-blind manner, an identical sublingual tablet of either 0.25 mg of triazolam or a placebo 30 minutes before administration of a conventional IAN block.
Negative_regulation (block) of IAN in IAN associated with inferior alveolar nerve, emergencies and pulpitis
8) Confidence 0.40 Published 2008 Journal J Endod Section Abstract Doc Link 18793913 Disease Relevance 0.65 Pain Relevance 0.75
For mandibular posterior teeth, a dose of 800 mg of ibuprofen given 45 minutes before the administration of the IAN block did not result in a statistically significant increase in anesthetic success in patients with irreversible pulpitis.


Negative_regulation (block) of IAN in teeth
9) Confidence 0.40 Published 2010 Journal J Endod Section Body Doc Link 20171351 Disease Relevance 0.07 Pain Relevance 0
They considered anesthesia to be successful when two consecutive 80 readings were obtained within 10 minutes of the IAN block and infiltration injection, and the 80 reading was sustained continuously through the 60th minute.
Negative_regulation (block) of IAN in IAN
10) Confidence 0.40 Published 2008 Journal J Am Dent Assoc Section Body Doc Link 18762633 Disease Relevance 0 Pain Relevance 0
METHODS: One hundred endodontic emergency patients diagnosed with irreversible pulpitis of a mandibular posterior tooth randomly received, in a double-blind manner, identical capsules of either 800 mg ibuprofen or placebo 45 minutes before the administration of a conventional IAN block.
Negative_regulation (block) of IAN in capsules
11) Confidence 0.40 Published 2010 Journal J Endod Section Body Doc Link 20171351 Disease Relevance 0.09 Pain Relevance 0
CONCLUSIONS: The results of this study suggest that the mylohyoid nerve block does not by itself predictably provide pulpal anesthesia in mandibular teeth and does not significantly enhance pulpal anesthesia when administered in combination with the IAN block.


Negative_regulation (block) of IAN in IAN
12) Confidence 0.40 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 10348512 Disease Relevance 0 Pain Relevance 0
Access was begun 15 minutes after completion of the IAN block, and all patients had profound lip numbness.
Negative_regulation (block) of IAN in IAN associated with hypesthesia and inferior alveolar nerve
13) Confidence 0.40 Published 2008 Journal J Endod Section Abstract Doc Link 18793913 Disease Relevance 0.65 Pain Relevance 0.81
METHODS: Forty-six adult volunteers randomly received a conventional IAN block or an IAN block administered with a peripheral nerve stimulator at 2 separate appointments.
Negative_regulation (block) of IAN in IAN
14) Confidence 0.35 Published 2010 Journal J Endod Section Body Doc Link 20171357 Disease Relevance 0 Pain Relevance 0
For the conventional IAN block, successful pulpal anesthesia ranged from 32%-45%.
Negative_regulation (block) of IAN in IAN
15) Confidence 0.35 Published 2010 Journal J Endod Section Body Doc Link 20171357 Disease Relevance 0 Pain Relevance 0
The combinations were as follows: mylohyoid nerve block (1.8 mL of 2% lidocaine with 1:100,000 epinephrine) + IAN block (3.6 mL of 2% lidocaine with 1:100,000 epinephrine); mock mylohyoid nerve block + IAN block (3.6 mL of 2% lidocaine with 1:100,000 epinephrine); mylohyoid nerve block (1.8 mL of 2% lidocaine with 1:100,000 epinephrine) + mock IAN block.
Negative_regulation (block) of IAN in nerve
16) Confidence 0.35 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 10348512 Disease Relevance 0 Pain Relevance 0
INTRODUCTION: The purpose of this prospective, randomized single-blind study was to compare the degree of pulpal anesthesia obtained with the inferior alveolar nerve (IAN) block administered by using a peripheral nerve stimulator compared with a conventional IAN block by using a cartridge of 2% lidocaine with 1:100,000 epinephrine.
Negative_regulation (block) of IAN in inferior associated with inferior alveolar nerve, anesthesia and lidocaine
17) Confidence 0.35 Published 2010 Journal J Endod Section Abstract Doc Link 20171357 Disease Relevance 0 Pain Relevance 0.38
RESULTS: With the peripheral nerve stimulator for the IAN block, successful pulpal anesthesia ranged from 32%-37%.
Negative_regulation (block) of IAN in peripheral nerve
18) Confidence 0.35 Published 2010 Journal J Endod Section Body Doc Link 20171357 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: We concluded that the IAN block administered with a peripheral nerve stimulator did not increase the success rate of pulpal anesthesia when compared with a conventional IAN block.


Negative_regulation (block) of IAN in IAN
19) Confidence 0.35 Published 2010 Journal J Endod Section Body Doc Link 20171357 Disease Relevance 0 Pain Relevance 0
RESULTS AND CONCLUSIONS: The success rate for the IAN block was 41% with ibuprofen and 35% with placebo, with no significant difference (P=.57) between the 2 groups.
Negative_regulation (block) of IAN
20) Confidence 0.35 Published 2010 Journal J Endod Section Body Doc Link 20171351 Disease Relevance 0.08 Pain Relevance 0

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