INT82118

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.46
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pthlh) Golgi apparatus (Pthlh) nucleus (Pthlh)
intracellular (Pthlh) cytoplasm (Pthlh)
Anatomy Link Frequency
parathyroid 2
Pthlh (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 10 98.84 Very High Very High Very High
Pain 3 86.08 High High
Inflammation 4 54.76 Quite High
Spinal cord 1 28.64 Quite Low
chemokine 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 63 95.04 Very High Very High Very High
Disease 7 92.72 High High
Lymphatic System Cancer 12 91.32 High High
Pain 3 86.08 High High
Plasma Cell Leukemia 3 82.16 Quite High
Cancer 29 78.72 Quite High
Bone Cancer 19 69.56 Quite High
Renal Insufficiency 1 64.00 Quite High
Necrosis 2 56.24 Quite High
INFLAMMATION 4 54.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since her blood PTH and calcitriol levels were suppressed and her parathyroid-hormone-related peptide (PTHrp) was mildly elevated, we believe that release of cytokines combined with PTHrp, as well as extensive osteolytic lesions, were the causes of the hypercalcemia.
Positive_regulation (elevated) of parathyroid-hormone-related peptide in parathyroid associated with hypercalcemia and cytokine
1) Confidence 0.47 Published 1999 Journal Leuk. Lymphoma Section Abstract Doc Link 10350350 Disease Relevance 0.68 Pain Relevance 0.14
Since her blood PTH and calcitriol levels were suppressed and her parathyroid-hormone-related peptide (PTHrp) was mildly elevated, we believe that release of cytokines combined with PTHrp, as well as extensive osteolytic lesions, were the causes of the hypercalcemia.
Positive_regulation (elevated) of PTHrp in parathyroid associated with hypercalcemia and cytokine
2) Confidence 0.47 Published 1999 Journal Leuk. Lymphoma Section Abstract Doc Link 10350350 Disease Relevance 0.68 Pain Relevance 0.13
Elevated serum PTHrP is not a consistent finding in myeloma patients, and it remains unclear why myeloma patients present with increased renal tubular calcium reabsorption.
Positive_regulation (Elevated) of PTHrP
3) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 1.10 Pain Relevance 0.03

General Comments

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