INT82140

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Context Info
Confidence 0.14
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.70
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Raf1) mitochondrion (Raf1) plasma membrane (Raf1)
nucleus (Raf1) cytoskeleton organization (Raf1) cytoplasm (Raf1)
Anatomy Link Frequency
Hepa 1-6 1
Raf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.90 Very High Very High Very High
Analgesic 1 97.76 Very High Very High Very High
adenocard 2 94.60 High High
Central nervous system 1 77.00 Quite High
Morphine 2 76.76 Quite High
Spinal cord 1 75.08 Quite High
Inflammatory response 4 53.92 Quite High
Inflammation 3 21.48 Low Low
ischemia 2 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 31 99.22 Very High Very High Very High
Retina Disease 4 97.28 Very High Very High Very High
Optic Nerve Injuries 34 96.12 Very High Very High Very High
Hepatotoxicity 2 95.76 Very High Very High Very High
Toxicity 1 93.80 High High
Injury 32 92.80 High High
Stress 3 90.36 High High
Death 51 89.20 High High
Hemorrhagic Shock 1 79.96 Quite High
Shock 1 59.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclic adenosine monophosphate inhibits the phosphoinositide/MAP kinase hyperpermeability pathway via the protein kinase A (PKA)-dependent inhibition of Raf-1.
Negative_regulation (inhibition) of Raf-1
1) Confidence 0.14 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18227303 Disease Relevance 0.08 Pain Relevance 0.25
Survival and anti-apoptotic signals [51] such as XIAP, ERK2, SOS, c-Raf-1, and YY1 are downregulated.
Negative_regulation (downregulated) of c-Raf-1 associated with apoptosis
2) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.34 Pain Relevance 0.10
Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activity.
Negative_regulation (inhibition) of Raf-1 in Hepa 1-6 associated with paracetamol
3) Confidence 0.02 Published 1999 Journal Toxicol. Sci. Section Title Doc Link 10353317 Disease Relevance 0.28 Pain Relevance 1.04

General Comments

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