INT82141

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Context Info
Confidence 0.12
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.81
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Raf1) mitochondrion (Raf1) plasma membrane (Raf1)
nucleus (Raf1) cytoskeleton organization (Raf1) cytoplasm (Raf1)
Anatomy Link Frequency
chondrocytes 2
Hepa 1-6 1
Raf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.28 Very High Very High Very High
Kinase C 210 98.96 Very High Very High Very High
Analgesic 1 97.76 Very High Very High Very High
addiction 5 21.60 Low Low
Osteoarthritis 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
spinal inflammation 5 5.00 Very Low Very Low Very Low
Immobilon 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 95.76 Very High Very High Very High
Toxicity 1 93.80 High High
Stress 1 90.36 High High
Chondrocalcinosis 60 85.84 High High
Cancer 5 78.60 Quite High
Cardiovascular Disease 5 78.16 Quite High
Disease 15 71.52 Quite High
Repression 10 67.80 Quite High
Aging 15 5.00 Very Low Very Low Very Low
Osteoarthritis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data supported a major role for the Ras/Raf-1 pathway in TGF-?
Positive_regulation (role) of Raf-1
1) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.06
1-induced expression of Ank in chondrocytes, a finding consistent with data demonstrating the activation of Ras and Raf-1 by TGF-?
Positive_regulation (activation) of Raf-1 in chondrocytes
2) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0
Induction of Ank is mediated by the dual activation of Ras, Raf-1, and MEK-1/ERK cascade and Ca2+-dependent PKC but is independent of the Smad signaling pathway.
Positive_regulation (activation) of Raf-1 associated with kinase c
3) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.53 Pain Relevance 0.09
1 was strongly dependent on the activation of Ras and Raf-1 since transfection with dominant-negative forms of these proteins completely inhibited the stimulating effect of TGF-?
Positive_regulation (activation) of Raf-1
4) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0
1 increases ePPi levels, mainly by the induction of the Ank gene, which requires activation of Ras, Raf-1, ERK, and Ca2+-dependent PKC pathways in chondrocytes.



Positive_regulation (activation) of Raf-1 in chondrocytes associated with kinase c
5) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.20
Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activity.
Positive_regulation (activation) of Raf-1 in Hepa 1-6 associated with paracetamol
6) Confidence 0.02 Published 1999 Journal Toxicol. Sci. Section Title Doc Link 10353317 Disease Relevance 0.28 Pain Relevance 1.04

General Comments

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