INT82143

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Context Info
Confidence 0.18
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.33
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Raf1) mitochondrion (Raf1) plasma membrane (Raf1)
nucleus (Raf1) cytoskeleton organization (Raf1) cytoplasm (Raf1)
Anatomy Link Frequency
chondrocytes 2
Hepa 1-6 1
Raf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.50 Very High Very High Very High
Kinase C 126 97.80 Very High Very High Very High
Analgesic 1 97.76 Very High Very High Very High
Osteoarthritis 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 95.76 Very High Very High Very High
Toxicity 1 93.80 High High
Stress 1 90.36 High High
Repression 6 53.64 Quite High
Chondrocalcinosis 36 5.00 Very Low Very Low Very Low
Aging 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
Calcification 3 5.00 Very Low Very Low Very Low
Ankylosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate further the contribution of the MEK-1 pathway, we modulated the expression of Ras and Raf-1 proteins, which are known to trigger MEK-1 activation in chondrocytes [34].
Gene_expression (expression) of Raf-1 in chondrocytes
1) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.05 Pain Relevance 0
Contribution of Ras and Raf-1 pathways to TGF-?
Gene_expression (Contribution) of Raf-1
2) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.30
When chondrocytes were transfected to overexpress constitutively active Ras (Figure 6a) or Raf-1 (Figure 6b), the basal expression of Ank was increased by 2-fold and 1.5-fold, respectively.
Gene_expression (overexpress) of Raf-1 in chondrocytes
3) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.26
Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activity.
Gene_expression (expression) of Raf-1 in Hepa 1-6 associated with paracetamol
4) Confidence 0.02 Published 1999 Journal Toxicol. Sci. Section Title Doc Link 10353317 Disease Relevance 0.28 Pain Relevance 1.04

General Comments

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