INT82166

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 1999
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 14
Total Number 18
Disease Relevance 7.57
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
coronary artery 1
endothelial cell 1
hip 1
endothelium 1
platelet 1
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
neuralgia 3 98.44 Very High Very High Very High
Cannabinoid 1 97.60 Very High Very High Very High
opiate 3 97.28 Very High Very High Very High
Angina 14 96.04 Very High Very High Very High
Pain 8 92.96 High High
cva 54 92.52 High High
Inflammation 33 89.44 High High
Morphine 7 87.44 High High
Opioid 1 81.88 Quite High
Bioavailability 1 81.84 Quite High
Disease Link Frequency Relevance Heat
Hypertension 39 99.64 Very High Very High Very High
Calciphylaxis 41 98.94 Very High Very High Very High
Coronary Artery Disease 147 98.92 Very High Very High Very High
Aseptic Necrosis Of Bone 3 98.50 Very High Very High Very High
Neuralgia 2 98.44 Very High Very High Very High
Cardiovascular Disease 16 96.88 Very High Very High Very High
Congenital Anomalies 5 96.08 Very High Very High Very High
Cv General 3 Under Development 64 96.04 Very High Very High Very High
Spasticity 10 95.76 Very High Very High Very High
Pain 6 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also possible that aspirin indirectly affects NOS-3 activity by acetylating other substrates within the platelet, but this remains to be determined.


Regulation (affects) of NOS-3 in platelet
1) Confidence 0.54 Published 2009 Journal Cardiovasc. Res. Section Body Doc Link 19377066 Disease Relevance 0 Pain Relevance 0
Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05).
Regulation (involved) of eNOS
2) Confidence 0.39 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0
Mifepristone inhibited the endometrial glandular epithelial eNOS expression and did not affect the endothelilal eNOS.
Neg (not) Regulation (affect) of eNOS
3) Confidence 0.31 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.14 Pain Relevance 0
This is the only known polymorphism changing the eNOS protein sequence, leading to speculation that genetic variation at this site may alter e-NOS activity or regulation and possibly leads to endothelial dysfunction and to pathogenesis of several cardiovascular diseases [7].
Regulation (changing) of eNOS associated with cardiovascular disease
4) Confidence 0.27 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954842 Disease Relevance 0.50 Pain Relevance 0
The recent body of evidence indicates that RhoA and its down stream effector, ROCK/Rho-kinase, are associated with hypercontraction of vascular smooth muscle of the coronary artery and regulation of eNOS activity.
Regulation (regulation) of eNOS in body
5) Confidence 0.24 Published 2009 Journal Korean Circulation Journal Section Abstract Doc Link PMC2801457 Disease Relevance 1.12 Pain Relevance 0.32
The opiate and cannabinoid stimulation of [Ca]i was attenuated in cells leeched of calcium, strongly suggesting that intracellular calcium levels regulate cNOS activity.
Regulation (regulate) of cNOS associated with cannabinoid and opiate
6) Confidence 0.23 Published 1999 Journal Cell. Signal. Section Abstract Doc Link 10353693 Disease Relevance 0 Pain Relevance 0.69
This is the only known polymorphism changing the eNOS protein sequence, leading to speculation that genetic variation at this site may alter e-NOS activity or regulation and possibly leads to endothelial dysfunction and to pathogenesis of several cardiovascular diseases [7].
Spec (may) Regulation (alter) of e-NOS associated with cardiovascular disease
7) Confidence 0.23 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954842 Disease Relevance 0.51 Pain Relevance 0
This is the only known polymorphism changing the eNOS protein sequence, leading to speculation that genetic variation at this site may alter e-NOS activity or regulation and possibly leads to endothelial dysfunction and to pathogenesis of several cardiovascular diseases [7].
Regulation (regulation) of e-NOS associated with cardiovascular disease
8) Confidence 0.23 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954842 Disease Relevance 0.51 Pain Relevance 0
We make the case that cNOS is responsible for a basal or 'tonal' level of NO; that this NO keeps particular types of cells in a state of inhibition and that activation of these cells occurs through disinhibition.
Regulation (responsible) of cNOS
9) Confidence 0.21 Published 2000 Journal Prog. Neurobiol. Section Abstract Doc Link 10739087 Disease Relevance 0 Pain Relevance 0.33
The change in eNOS mRNA from baseline was highly correlated with the change in the expression of PPARGC1A and SIRT1 in the CR group (r = 0.86, p < 0.001 and r = 0.80, p < 0.001, respectively; unpublished data), suggesting synergistic regulation among PPARGC1A, SIRT1, and eNOS.
Regulation (change) of eNOS
10) Confidence 0.20 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.07 Pain Relevance 0
The change in eNOS mRNA from baseline was highly correlated with the change in the expression of PPARGC1A and SIRT1 in the CR group (r = 0.86, p < 0.001 and r = 0.80, p < 0.001, respectively; unpublished data), suggesting synergistic regulation among PPARGC1A, SIRT1, and eNOS.
Regulation (regulation) of eNOS
11) Confidence 0.20 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.06 Pain Relevance 0
Presently, we are exploring the effects of heavy metals and other pollutants on cNOS activity, measured as real time NO release, in immunocytes and pedal ganglia from M. edulis.
Regulation (effects) of cNOS in ganglia
12) Confidence 0.18 Published 2000 Journal Acta. Biol. Hung. Section Abstract Doc Link 11034156 Disease Relevance 0 Pain Relevance 0.08
STS may restore endothelial cell dysfunction in CPLX through its antioxidant actions and have a positive effect on eNOS uncoupling and eNO generation.
Regulation (effect) of eNOS in endothelial cell associated with calciphylaxis
13) Confidence 0.10 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 0.96 Pain Relevance 0.26
OBJECTIVE: We hypothesized that, similar to idiopathic hip osteonecrosis, the T-786C mutation of the endothelial nitric oxide synthase (eNOS) gene affecting nitric oxide (NO) production was associated with neuralgia-inducing cavitational osteonecrosis of the jaws (NICO).
Regulation (affecting) of eNOS in hip associated with aseptic necrosis of bone and neuralgia
14) Confidence 0.07 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 20185342 Disease Relevance 0.44 Pain Relevance 0.17
Although the distribution of genotypes in both the CAD and the control groups satisfied the Hardy-Weinberg equilibrium, the G894T polymorphism of the NOS3 gene was significantly associated with the presence of CAD in our patients (?
Regulation (polymorphism) of NOS3 associated with coronary artery disease
15) Confidence 0.05 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2850180 Disease Relevance 0.89 Pain Relevance 0
To further investigate the genetic involvement of the eNOS gene in essential hypertension, we examined the frequency of T-786-->C variant in two independent populations of persons with essential hypertension in Kyoto (n=215) and Kumamoto (n=186) and compared the frequency with that in each age- and gender-matched control (233 controls in Kyoto and 223 controls in Kumamoto).
Spec (investigate) Regulation (involvement) of eNOS associated with hypertension
16) Confidence 0.05 Published 2000 Journal Hypertens. Res. Section Abstract Doc Link 11131266 Disease Relevance 1.03 Pain Relevance 0.19
We studied whether the 27 base pair (bp) tandem repeat polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) gene was associated with coronary artery disease (CAD) in a hospital-based Taiwanese population.
Spec (whether) Regulation (intron) of eNOS in coronary artery associated with coronary artery disease
17) Confidence 0.04 Published 2002 Journal Cardiology Section Abstract Doc Link 11978951 Disease Relevance 0.39 Pain Relevance 0
The constitutive endothelial nitric oxide synthase (NOS3) is expressed in the endothelium and is encoded by a 26-exon gene located on chromosome 7q35 to 36; the gene, with a total size of 21 kb, encodes an mRNA of 4052 nucleotides.45 The NOS3 gene is expressionally and functionally regulated through multiple regulatory steps and entails several polymorphisms, some of which bear functional consequences.4
Regulation (regulated) of NOS3 in endothelium
18) Confidence 0.03 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2850180 Disease Relevance 0.71 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox