INT82168

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 9.72
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) nucleus (S100b) cytoplasm (S100b)
Anatomy Link Frequency
brain 4
astrocytes 3
Plasma 1
skull 1
carotid artery 1
S100b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 33 99.88 Very High Very High Very High
anesthesia 32 99.78 Very High Very High Very High
headache 6 99.32 Very High Very High Very High
Glutamate 11 98.08 Very High Very High Very High
imagery 6 97.00 Very High Very High Very High
ischemia 46 92.28 High High
tetrodotoxin 9 91.16 High High
sodium channel 3 90.24 High High
Calcium channel 3 86.88 High High
palliative 1 83.68 Quite High
Disease Link Frequency Relevance Heat
Sepsis 12 100.00 Very High Very High Very High
Skull Fractures 2 99.96 Very High Very High Very High
Dizziness 2 99.92 Very High Very High Very High
Lung Cancer 5 99.90 Very High Very High Very High
Endotoxemia 2 99.68 Very High Very High Very High
Metastasis 72 99.38 Very High Very High Very High
Headache 9 99.32 Very High Very High Very High
Encephalopathy 2 99.00 Very High Very High Very High
Myocardial Infarction 42 98.96 Very High Very High Very High
Disease 134 98.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with gabapentin prevented the upregulation of GFAP, S100B, and NSE in all brain regions of diabetic rats.
Positive_regulation (upregulation) of S100B in brain
1) Confidence 0.68 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.06 Pain Relevance 0
The data show that a sustained increase in serum S100B levels is associated with neurological dysfunction, as witnessed by a positive correlation between S100B values and the results of the neuropsychological tests.
Positive_regulation (increase) of S100B associated with anesthesia
2) Confidence 0.66 Published 2004 Journal Anaesthesia Section Abstract Doc Link 15023104 Disease Relevance 0.10 Pain Relevance 0.10
The presence of skull fracture, elevated serum protein S-100B, dizziness, and headache may help the emergency room physician to identify patients at risk of PCSs and to refer them for further examination and follow-up.
Positive_regulation (elevated) of serum protein S-100B in skull associated with emergencies, dizziness, headache and skull fractures
3) Confidence 0.60 Published 2003 Journal Eur. J. Neurol. Section Abstract Doc Link 12603294 Disease Relevance 1.51 Pain Relevance 0.19
The brain is a source of S100B increase during endotoxemia in the pig.
Positive_regulation (increase) of S100B in brain associated with endotoxemia and anesthesia
4) Confidence 0.60 Published 2010 Journal Anesth. Analg. Section Title Doc Link 19897802 Disease Relevance 0.37 Pain Relevance 0.10
In contrast to the pharmacologic manipulations mentioned above, glutamate and alpha-ketoglutarate added at high concentrations to the medium prevented both OGD- and REO-induced S100B outputs.
Positive_regulation (induced) of S100B associated with glutamate
5) Confidence 0.59 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.40
Although several clinical studies have shown that increased serum concentrations of protein S100B predict ischaemic brain damage after cardiac surgery, S100B may also be released from the heart or other injured tissue.
Positive_regulation (increased) of S100B in heart
6) Confidence 0.48 Published 2004 Journal Anaesthesia Section Abstract Doc Link 15023104 Disease Relevance 0.06 Pain Relevance 0
In a study looking at the presence of S100B in the serum of 38 patients with lung carcinoma, an elevated S100B level was either associated with brain metastases or with the presence of imaging changes suggestive of chronic, diffuse cerebral microvascular disease [80].
Positive_regulation (elevated) of S100B in brain associated with lung cancer, disease, imagery and metastasis
7) Confidence 0.47 Published 2008 Journal Radiat Oncol Section Body Doc Link PMC2556333 Disease Relevance 1.43 Pain Relevance 0.34
Plasma S100 (S100B) proteins increase in sepsis.
Positive_regulation (increase) of S100B in Plasma associated with sepsis
8) Confidence 0.46 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 19897802 Disease Relevance 0.36 Pain Relevance 0
Similarly, the presence of SNP, HA or NO precursor L: -arginine in the medium, or inhibition of NO synthase by L-NAME also failed to alter OGD- and REO-induced S100B outputs.
Positive_regulation (induced) of S100B
9) Confidence 0.43 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.27
Incubation of rat cortical slices in a medium that was not containing oxygen and glucose (oxygen-glucose deprivation, OGD) caused a 200% increase in the release of S100B.
Positive_regulation (increase) of S100B
10) Confidence 0.40 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0
During uncomplicated CEA under local anesthesia, there is no relevant increase of S-100B.
Neg (no) Positive_regulation (increase) of S-100B associated with anesthesia
11) Confidence 0.34 Published 2007 Journal Ann Vasc Surg Section Abstract Doc Link 17521874 Disease Relevance 0.06 Pain Relevance 0.30
Patients who responded to treatment (stable or regressing metastatic disease) showed constant or declining S100B levels in 38 of 40 patients (95%) at the interim analysis, at 8 weeks this was further increased to 39 of 40 patients (98%; P < 0.001).
Positive_regulation (increased) of S100B associated with metastasis
12) Confidence 0.34 Published 1999 Journal Br. J. Dermatol. Section Abstract Doc Link 10354072 Disease Relevance 0.59 Pain Relevance 0.08
RESULTS: During migraine attacks elevated s100b levels could be observed.
Positive_regulation (elevated) of s100b
13) Confidence 0.31 Published 2009 Journal Headache Section Body Doc Link 18783450 Disease Relevance 0.09 Pain Relevance 0
The aim of the study was to evaluate whether cross-clamping of the carotid artery for carotid endarterectomy (CEA) under local anesthesia is associated with the same S-100B release pattern as during general anesthesia, where an increase in S-100B concentration in the jugular vein blood of 120% has been reported.
Positive_regulation (increase) of S-100B in carotid artery associated with anesthesia
14) Confidence 0.30 Published 2007 Journal Ann Vasc Surg Section Abstract Doc Link 17521874 Disease Relevance 0 Pain Relevance 0.36
This was based on our demonstration that activated microglia overexpressing interleukin-1 (IL-1), a potent immune response-generating cytokine, and activated astrocytes overexpressing S100B, a cytokine that promotes excessive neurite growth, in Alzheimer’s disease (Griffin et al 1989).
Positive_regulation (activated) of S100B in astrocytes associated with disease and cytokine
15) Confidence 0.23 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656298 Disease Relevance 0.99 Pain Relevance 0.28
Activations of astrocytes in schizophrenia and AD are also reflected by subpopulations of patients with increased S100B serum concentrations.128,129 S100B is an astrocytic protein that regulates calcium homeostasis.
Positive_regulation (increased) of S100B in astrocytes associated with disease and schizophrenia
16) Confidence 0.20 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.65 Pain Relevance 0.09
Activations of astrocytes in schizophrenia and AD are also reflected by subpopulations of patients with increased S100B serum concentrations.128,129 S100B is an astrocytic protein that regulates calcium homeostasis.
Positive_regulation (increased) of S100B in astrocytes associated with disease and schizophrenia
17) Confidence 0.20 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.60 Pain Relevance 0.09
CONCLUSION: S100B protein increases significantly in open cardiac surgery under CPB.
Positive_regulation (increases) of S100B
18) Confidence 0.07 Published 2007 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 17923015 Disease Relevance 0 Pain Relevance 0
S-100B levels reportedly increase with the development of encephalopathy in patients with severe sepsis and septic shock and in those with post-traumatic stress one year after suffering moderate cranio-encephalic trauma [28,29].
Positive_regulation (increase) of S-100B associated with stress, encephalopathy, injury and sepsis
19) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2206421 Disease Relevance 1.44 Pain Relevance 0.12
Concerning reliable biochemical markers of brain tissue damage, increased serum levels of the low molecular weight protein S100B have been reported after cardiac arrest correlating with neurological complications.
Positive_regulation (increased) of protein S100B in brain associated with myocardial infarction
20) Confidence 0.02 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 1.42 Pain Relevance 0.36

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