INT82177

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Context Info
Confidence 0.58
First Reported 1998
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 5.83
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mitral valve 2
muscle 1
H2-Q10 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 3 97.52 Very High Very High Very High
imagery 21 82.68 Quite High
qutenza 2 80.52 Quite High
Pain 3 44.48 Quite Low
Spinal cord 15 38.96 Quite Low
Peripheral nervous system 3 33.68 Quite Low
Sicca syndrome 18 20.32 Low Low
Bile 6 5.00 Very Low Very Low Very Low
peripheral neuropathy 6 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypolipidemia 27 99.80 Very High Very High Very High
Cerebellar Ataxia 144 99.76 Very High Very High Very High
Frailty 27 99.70 Very High Very High Very High
Friedreich Ataxia 159 99.28 Very High Very High Very High
Ataxia 276 99.24 Very High Very High Very High
Heart Rate Under Development 3 98.56 Very High Very High Very High
Syndrome 99 98.44 Very High Very High Very High
Cv General 3 Under Development 3 97.52 Very High Very High Very High
Coronary Artery Disease 5 96.84 Very High Very High Very High
Cardiovascular Disease 3 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coenzyme Q10 deficiency has been observed in patients with congestive heart failure, angina pectoris, coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse.
Negative_regulation (deficiency) of Q10 in mitral valve associated with heart rate under development, angina, cardiovascular disease, hypertension and coronary heart disease
1) Confidence 0.58 Published 2006 Journal Fiziol Zh Section Abstract Doc Link 17176844 Disease Relevance 0.66 Pain Relevance 0.10
Coenzyme Q10 deficiency has been observed in patients with congestive heart failure, angina pectoris, coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse and after coronary revascularization.
Negative_regulation (deficiency) of Q10 in mitral valve associated with heart rate under development, angina, coronary artery disease, hypertension and coronary heart disease
2) Confidence 0.14 Published 1998 Journal J Assoc Physicians India Section Abstract Doc Link 11273351 Disease Relevance 1.02 Pain Relevance 0.15
Coenzyme Q10 deficiency with cerebellar ataxia
Negative_regulation (deficiency) of Q10 associated with cerebellar ataxia
3) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 1.33 Pain Relevance 0
For most ARCA there is no specific drug treatment except for coenzyme Q10 deficiency and abetalipoproteinemia.



Neg (except) Negative_regulation (deficiency) of Q10 associated with hypolipidemia and cerebellar ataxia
4) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1664553 Disease Relevance 1.15 Pain Relevance 0.04
This is a syndrome characterized by childhood-onset ataxia and cerebellar atrophy, and markedly reduced levels of coenzyme Q10 in muscle biopsies [188].
Negative_regulation (reduced) of Q10 in muscle associated with ataxia, syndrome and frailty
5) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 1.50 Pain Relevance 0
However, in the absence of NADH, reduced coenzyme Q10 (Q10H2=ubiquinol) was oxidized at a rate of 15+/-6 nmol min-1 mg protein-1 depending on degree of purification.
Negative_regulation (reduced) of Q10
6) Confidence 0.01 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10354495 Disease Relevance 0.08 Pain Relevance 0.08
The rate of Q10H2 oxidation was not stimulated by addition of equal amounts of Q10 and Q10H2.
Negative_regulation (amounts) of Q10
7) Confidence 0.01 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10354495 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

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