INT82177

Context Info Confidence 0.58 First Reported 1998 Last Reported 2006 Negated 1 Speculated 0 Reported most in Abstract Documents 5 Total Number 7 Disease Relevance 5.83 Pain Relevance 0.45

Anatomy Link Frequency mitral valve 2 muscle 1 H2-Q10 (Mus musculus)

Pain Link Frequency Relevance Heat Angina 3 97.52 imagery 21 82.68 qutenza 2 80.52 Pain 3 44.48 Spinal cord 15 38.96 Peripheral nervous system 3 33.68 Sicca syndrome 18 20.32 Bile 6 5.00 peripheral neuropathy 6 5.00 Action potential 6 5.00

Disease Link Frequency Relevance Heat Hypolipidemia 27 99.80 Cerebellar Ataxia 144 99.76 Frailty 27 99.70 Friedreich Ataxia 159 99.28 Ataxia 276 99.24 Heart Rate Under Development 3 98.56 Syndrome 99 98.44 Cv General 3 Under Development 3 97.52 Coronary Artery Disease 5 96.84 Cardiovascular Disease 3 96.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Coenzyme Q10 deficiency has been observed in patients with congestive heart failure, angina pectoris, coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse.

Negative_regulation (deficiency) of Q10 in mitral valve associated with heart rate under development, angina, cardiovascular disease, hypertension and coronary heart disease

1) Confidence 0.58 Published 2006 Journal Fiziol Zh Section Abstract Doc Link 17176844 Disease Relevance 0.66 Pain Relevance 0.10

Coenzyme Q10 deficiency has been observed in patients with congestive heart failure, angina pectoris, coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse and after coronary revascularization.

Negative_regulation (deficiency) of Q10 in mitral valve associated with heart rate under development, angina, coronary artery disease, hypertension and coronary heart disease

2) Confidence 0.14 Published 1998 Journal J Assoc Physicians India Section Abstract Doc Link 11273351 Disease Relevance 1.02 Pain Relevance 0.15

Coenzyme Q10 deficiency with cerebellar ataxia

Negative_regulation (deficiency) of Q10 associated with cerebellar ataxia

3) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 1.33 Pain Relevance 0

For most ARCA there is no specific drug treatment except for coenzyme Q10 deficiency and abetalipoproteinemia.

Neg (except) Negative_regulation (deficiency) of Q10 associated with hypolipidemia and cerebellar ataxia

4) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1664553 Disease Relevance 1.15 Pain Relevance 0.04

This is a syndrome characterized by childhood-onset ataxia and cerebellar atrophy, and markedly reduced levels of coenzyme Q10 in muscle biopsies [188].

Negative_regulation (reduced) of Q10 in muscle associated with ataxia, syndrome and frailty

5) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 1.50 Pain Relevance 0

However, in the absence of NADH, reduced coenzyme Q10 (Q10H2=ubiquinol) was oxidized at a rate of 15+/-6 nmol min-1 mg protein-1 depending on degree of purification.

Negative_regulation (reduced) of Q10

6) Confidence 0.01 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10354495 Disease Relevance 0.08 Pain Relevance 0.08

The rate of Q10H2 oxidation was not stimulated by addition of equal amounts of Q10 and Q10H2.

Negative_regulation (amounts) of Q10

7) Confidence 0.01 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10354495 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

This test has worked.