INT822

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Context Info
Confidence 0.78
First Reported 1978
Last Reported 2011
Negated 52
Speculated 17
Reported most in Body
Documents 529
Total Number 546
Disease Relevance 302.16
Pain Relevance 63.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
MCF-7 12
neurons 11
epithelial cells 9
uterine 7
MDA-MB-231 5
ESR1 (Homo sapiens)
ESR1 - C325G (1)
Pain Link Frequency Relevance Heat
Inflammation 1984 100.00 Very High Very High Very High
Pain 990 100.00 Very High Very High Very High
spinal inflammation 337 100.00 Very High Very High Very High
cytokine 309 100.00 Very High Very High Very High
Oxycodone 146 100.00 Very High Very High Very High
COX2 14 100.00 Very High Very High Very High
Opioid 1081 99.98 Very High Very High Very High
tramadol 142 99.98 Very High Very High Very High
agonist 2205 99.92 Very High Very High Very High
rheumatoid arthritis 553 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 10837 100.00 Very High Very High Very High
Breast Cancer 9257 100.00 Very High Very High Very High
Disease 3421 100.00 Very High Very High Very High
INFLAMMATION 1897 100.00 Very High Very High Very High
Carcinoma 1442 100.00 Very High Very High Very High
Inflammatory Breast Neoplasms 1415 100.00 Very High Very High Very High
Pain 1113 100.00 Very High Very High Very High
Stress 969 100.00 Very High Very High Very High
Toxicity 553 100.00 Very High Very High Very High
Uterine Fibroids 509 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytotoxicity of the motherwort aqueous ethanol extract (MAEE) was analyzed with MTT assay on ER negative MDA-MB-231 and ER positive MCF-7 human breast cancer cell lines.
Neg (negative) Spec (analyzed) Gene_expression (negative) of ER in MDA-MB-231
1) Confidence 0.78 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19330917 Disease Relevance 0.08 Pain Relevance 0
Therefore, we analyzed the binding of [3H]-diprenorphine in human neuroblastoma cells stably transfected with the estrogen receptor cDNA (SK-ER3 cell line).
Gene_expression (transfected) of estrogen receptor cDNA associated with neuroblastoma
2) Confidence 0.78 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 9892851 Disease Relevance 0.17 Pain Relevance 0.25
The ethanol extract of the fruits of Vitex rotundifolia (VRE) and its four major compounds (casticin, luteolin, rotundifuran and agnuside) were tested for their estrogen-like activity by using the modified cell proliferation assay (E-SCREEN assessment system), as well as the estrogen receptor (ER(alpha)), estrogen receptor-regulated progesterone receptor and pS2 mRNA expression in MCF-7 cells.
Gene_expression (expression) of estrogen receptor in MCF-7
3) Confidence 0.77 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17883902 Disease Relevance 0.07 Pain Relevance 0.11
The ethanol extract of the fruits of Vitex rotundifolia (VRE) and its four major compounds (casticin, luteolin, rotundifuran and agnuside) were tested for their estrogen-like activity by using the modified cell proliferation assay (E-SCREEN assessment system), as well as the estrogen receptor (ER(alpha)), estrogen receptor-regulated progesterone receptor and pS2 mRNA expression in MCF-7 cells.
Gene_expression (expression) of ER in MCF-7
4) Confidence 0.77 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17883902 Disease Relevance 0.07 Pain Relevance 0.11
ER alpha protein was found to be weakly expressed in three of ten explants.
Gene_expression (expressed) of ER alpha protein
5) Confidence 0.76 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
CONCLUSION: In view of our observation that ER beta but not ER alpha is expressed regularly in normal human synovia in high amounts, we propose that estrogen could play a significant role in synovial membrane function in women and men, operating preferably via the ER beta isoform.


Gene_expression (expressed) of ER alpha
6) Confidence 0.76 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
Concomitant with the age related reduction in the oestrogen negative feedback on LH secretion was a decline in hypothalamic oestrogen receptor-alpha (ERalpha) expression and increased expression of repressor of ER activity gene (REA) at 210 days of age.
Gene_expression (expression) of ERalpha
7) Confidence 0.75 Published 2006 Journal Soc Reprod Fertil Suppl Section Abstract Doc Link 16866307 Disease Relevance 0.14 Pain Relevance 0.07
GR expression (GR number), cortisol levels (fluorescence polarization immunoassay, FPIA), ESR, CRP, and the presence of swollen and painful knees were determined.
Spec (determined) Gene_expression (expression) of ESR in knees associated with pain
8) Confidence 0.75 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114259 Disease Relevance 0.97 Pain Relevance 0.51
GR expression (GR-number and GR-affinity), serum cortisol levels, ESR, CRP, painful and swollen joints were measured.
Gene_expression (expression) of ESR in joints
9) Confidence 0.75 Published 2002 Journal Clin. Exp. Rheumatol. Section Body Doc Link 12175100 Disease Relevance 0.09 Pain Relevance 0
In the 'ovarian-type' stroma, several genes involved in estrogen metabolism were overexpressed including STAR and ESR1 genes.
Gene_expression (overexpressed) of ESR1 in stroma
10) Confidence 0.75 Published 2004 Journal Oncogene Section Abstract Doc Link 15489895 Disease Relevance 0.60 Pain Relevance 0.07
During an in-patient multidisciplinary rehabilitation programme the levels of ICAM-1 in serum and the majority of all investigated laboratory and clinical parameters such as ESR, CRP, SAA, fibrinogen, pain, swollen and painful joint count, morning stiffness and health assessment questionnaire improved.
Gene_expression (levels) of ESR in joint associated with pain
11) Confidence 0.75 Published 1999 Journal Wien Med Wochenschr Section Abstract Doc Link 10637965 Disease Relevance 0.97 Pain Relevance 0.31
Univariate analysis showed significant differences in body temperature, serum WBC count, and ESR and CRP levels of the two patient groups.
Gene_expression (levels) of ESR in body
12) Confidence 0.75 Published 2003 Journal J Pediatr Orthop Section Abstract Doc Link 12724602 Disease Relevance 0.81 Pain Relevance 0.24
A recent paper showed that an inducible expression of ER?
Gene_expression (expression) of ER
13) Confidence 0.72 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.50 Pain Relevance 0.03
Because the ER and the AR belong to the steroid receptor superfamily, we sought to determine whether these pyranocoumarin compounds exerted similar activities against ER expression and function in breast cancer cells.
Gene_expression (expression) of ER associated with breast cancer
14) Confidence 0.72 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.71 Pain Relevance 0.09
A study has shown that the forced expression of ER?
Gene_expression (expression) of ER
15) Confidence 0.72 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.52 Pain Relevance 0
is able to regulate endogenous genes in a ligand-dependent manner, ectopically expressed ER?
Gene_expression (expressed) of ER
16) Confidence 0.72 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.52 Pain Relevance 0
Upregulated ESR1, GATA3, ERBB4, TFF1 and TFF3 gene expression was associated with ER+ ERBB2-amplified tumors.
Gene_expression (expression) of ESR1 associated with cancer
17) Confidence 0.71 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.95 Pain Relevance 0
No difference in ER protein expression (as defined by IHC) was observed between the two groups (p = 0.25) (Additionnal file 1-Table S7B).
Gene_expression (expression) of ER
18) Confidence 0.71 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.54 Pain Relevance 0
For the other histoclinical features, no difference was observed between the two groups except for ER expression (p < 0.05) (Additionnal file 1-Table S3).
Gene_expression (expression) of ER
19) Confidence 0.71 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.62 Pain Relevance 0.06
We recently demonstrated that the reduction in endometrial beta 3 integrin expression in PCOS was associated with elevated expression of ER-alpha and an over-expression of steroid receptor coactivators [20].
Gene_expression (expression) of ER associated with polycystic ovary syndrome
20) Confidence 0.69 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0.55 Pain Relevance 0.09

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