INT82226

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.36
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
Anatomy Link Frequency
bladder 2
epithelial cell 2
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 100 97.08 Very High Very High Very High
metalloproteinase 17 95.20 Very High Very High Very High
cINOD 61 89.16 High High
methotrexate 2 84.16 Quite High
Analgesic 2 78.84 Quite High
Inflammation 9 76.52 Quite High
COX-2 inhibitor 6 76.48 Quite High
Kinase C 2 64.40 Quite High
Prostatitis 1 59.84 Quite High
pain pelvic 1 49.76 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 87 99.90 Very High Very High Very High
Interstitial Cystitis 100 97.08 Very High Very High Very High
Cystitis 14 96.92 Very High Very High Very High
Colon Cancer 54 96.88 Very High Very High Very High
Uterine Fibroids 21 96.24 Very High Very High Very High
Hepatocellular Cancer 4 90.32 High High
Metastasis 9 89.60 High High
Death 23 88.56 High High
Head & Neck Cancer 5 84.40 Quite High
Cancer 87 82.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of EGF receptor protein decreased following each cycle of androgen ablation and increased subsequently after androgen supplementation.
Negative_regulation (decreased) of Gene_expression (expression) of EGF
1) Confidence 0.58 Published 2004 Journal Prostate Section Body Doc Link 15065088 Disease Relevance 0.06 Pain Relevance 0
Despite varying degrees of PGE2 inhibition, each NSAID group equally attenuated EGF-induced protein and nucleic acid synthesis.
Negative_regulation (attenuated) of Gene_expression (synthesis) of EGF-induced
2) Confidence 0.43 Published 1999 Journal J. Surg. Res. Section Body Doc Link 10357918 Disease Relevance 0.07 Pain Relevance 0
We previously determined that the urine of interstitial cystitis (IC) patients specifically contains a factor (antiproliferative factor [APF]) that inhibits primary bladder epithelial cell proliferation, and that it has significantly decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and increased levels of epidermal growth factor (EGF) compared with urine from asymptomatic controls and patients with bacterial cystitis.
Negative_regulation (decreased) of Gene_expression (levels) of EGF in epithelial cell associated with cystitis and interstitial cystitis
3) Confidence 0.39 Published 2001 Journal Urology Section Abstract Doc Link 11378043 Disease Relevance 1.13 Pain Relevance 0.46
It is therefore possible that decreased synthesis of HB-EGF by epithelial or other bladder cells contributes to the pathogenesis of IC by impairing normal bladder epithelial regeneration.
Spec (possible) Negative_regulation (decreased) of Gene_expression (synthesis) of EGF in bladder associated with interstitial cystitis
4) Confidence 0.35 Published 2005 Journal BMC Urol Section Body Doc Link PMC1131910 Disease Relevance 0.70 Pain Relevance 0.70
EGF-R and HER-2 combined targeted tyrosine-kinase inhibitors
Negative_regulation (inhibitors) of Gene_expression (combined) of EGF-R
5) Confidence 0.29 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.20 Pain Relevance 0.08
binding to the extracellular domain of EGFR, which results in cell-growth inhibition, induction of apoptosis and decreased production of EGF [7].
Negative_regulation (decreased) of Gene_expression (production) of EGF associated with apoptosis
6) Confidence 0.27 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2147013 Disease Relevance 0.73 Pain Relevance 0
The goal of this project was to specifically test the hypothesis that sulindac metabolites block activation and/or expression of the epidermal growth factor (EGF) receptor (EGFR).


Negative_regulation (block) of Gene_expression (expression) of EGF
7) Confidence 0.19 Published 2005 Journal J Carcinog Section Abstract Doc Link PMC1208922 Disease Relevance 0.73 Pain Relevance 0.32
Total EGFR expression and EGF-induced phosphorylation of ERK1/2 proteins was also downregulated following pretreatment with sulindac sulfide (Figure 3).
Negative_regulation (downregulated) of Gene_expression (expression) of EGF
8) Confidence 0.18 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.38 Pain Relevance 0
In addition, pterostilbene can inhibit TPA-induced expression of vascular endothelial growth factor, epidermal growth factor and epidermal growth factor receptor.
Negative_regulation (inhibit) of Gene_expression (expression) of epidermal growth factor
9) Confidence 0.18 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19447859 Disease Relevance 0.57 Pain Relevance 0.24
In addition, celecoxib affected the proliferation pathway by causing decreased expression of epidermal growth factor (EGF) receptor, FGF receptor 2, transforming growth factor-?
Negative_regulation (decreased) of Gene_expression (expression) of epidermal growth factor
10) Confidence 0.15 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.47 Pain Relevance 0.08
In addition, pterostilbene can inhibit TPA-induced expression of vascular endothelial growth factor, epidermal growth factor and epidermal growth factor receptor.
Negative_regulation (inhibit) of Gene_expression (expression) of epidermal growth factor
11) Confidence 0.13 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19447859 Disease Relevance 0.57 Pain Relevance 0.24
In a second study, asoprisnil also inhibited the expression of EGF, IGF-I, TGF?
Negative_regulation (inhibited) of Gene_expression (expression) of EGF
12) Confidence 0.10 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775068 Disease Relevance 0.75 Pain Relevance 0

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