INT8224

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2010
Negated 9
Speculated 2
Reported most in Abstract
Documents 73
Total Number 77
Disease Relevance 53.63
Pain Relevance 12.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CHGA)
Anatomy Link Frequency
neuron 13
neuronal 8
neuroendocrine cells 3
parathyroid 2
Neuro-2a 2
CHGA (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 80 100.00 Very High Very High Very High
Neuropeptide 19 100.00 Very High Very High Very High
calcitonin gene related peptide 1 100.00 Very High Very High Very High
Dynorphin 8 99.96 Very High Very High Very High
Serotonin 30 99.70 Very High Very High Very High
substance P 8 99.58 Very High Very High Very High
spastic colon 323 99.52 Very High Very High Very High
Somatostatin 50 99.04 Very High Very High Very High
Inflammatory stimuli 4 98.64 Very High Very High Very High
Kappa opioid receptor 3 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 567 100.00 Very High Very High Very High
Adhesions 5 100.00 Very High Very High Very High
Carcinoid 269 99.98 Very High Very High Very High
Carcinoma 119 99.88 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

337 99.52 Very High Very High Very High
Reprotox - General 1 10 99.52 Very High Very High Very High
Adenocarcinoma 54 99.44 Very High Very High Very High
Pancreatic Cancer 26 99.36 Very High Very High Very High
Disease 138 99.08 Very High Very High Very High
Neuroendocrine Cancer 146 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene expression of enkephalin, chromogranin A, chromogranin B, and secretogranin II and their respective peptide products were studied with in situ hybridization and radioimmunoassays after daily oral administration of haloperidol, clozapine, risperidone, or zotepine for 21 days.
Gene_expression (expression) of chromogranin A associated with enkephalin
1) Confidence 0.75 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10869885 Disease Relevance 0.08 Pain Relevance 0.26
Immunohistochemical staining of tumor cells showed positive expressions of prolactin, synaptophysin and chromogranin A in the cytoplasm of the tumor cells.
Gene_expression (expressions) of chromogranin A associated with cancer
2) Confidence 0.75 Published 2010 Journal Neuropathology Section Abstract Doc Link 19737358 Disease Relevance 1.12 Pain Relevance 0.11
CONCLUSIONS: The current study revealed that acinoductular cells characterized by dual expression of REG I and cytokeratin 19 also express insulin, chromogranin A and trypsin and therefore supports the hypothesis that transdifferentiation of fully differentiated (acinar) cells may be the main source of islet neogenesis in patients with chronic pancreatitis.
Gene_expression (express) of chromogranin A
3) Confidence 0.75 Published 2004 Journal Hepatogastroenterology Section Body Doc Link 15011837 Disease Relevance 0.07 Pain Relevance 0
We found that both neuronal cells expressed immunoreactivity for CGA and NSE, and small neuronal cells showed more intense CGA immunoreactivity, indicating an earlier stage of neuronal differentiation.
Gene_expression (expressed) of CGA in neuronal
4) Confidence 0.75 Published 1999 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 10587016 Disease Relevance 0.73 Pain Relevance 0.07
All of the neoplasms expressed chromogranin and two expressed synaptophysin.
Gene_expression (expressed) of chromogranin associated with cancer
5) Confidence 0.75 Published 2000 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 11075851 Disease Relevance 1.36 Pain Relevance 0.37
Microscopically, the epithelial areas were composed of well-defined nests of large cells with peripheral palisading expressing low-molecular-weight keratin, synaptophysin, chromogranin, and neuron-specific enolase.
Gene_expression (expressing) of chromogranin in neuron
6) Confidence 0.75 Published 2001 Journal Ann Diagn Pathol Section Abstract Doc Link 11510007 Disease Relevance 0.96 Pain Relevance 0.09
Chromogranin A and synaptophysin were detected in rare cells.
Gene_expression (detected) of Chromogranin A
7) Confidence 0.75 Published 2008 Journal Virchows Arch. Section Abstract Doc Link 18193278 Disease Relevance 1.07 Pain Relevance 0.11
Population of cells expressing neuron-specific enolase, synaptophysin, and chromogranin A, which were stained by paraldehyde-fuchsin, was demonstrated in subodontoblastic layer of the dental pulp.
Gene_expression (expressing) of chromogranin A in dental pulp
8) Confidence 0.75 Published 2007 Journal Morfologiia Section Abstract Doc Link 17722571 Disease Relevance 0 Pain Relevance 0.08
Immunohistochemical studies were positive for MIC-2, NSE, C-KIT, vimentin, Class III-beta tublin and glycogen, but negative for NFP, synaptophysin, chromogranin A and GFAP.
Neg (negative) Gene_expression (negative) of chromogranin A
9) Confidence 0.75 Published 2004 Journal No To Shinkei Section Abstract Doc Link 15112448 Disease Relevance 1.10 Pain Relevance 0.12
Examination of the biopsy by immunohistochemistry and ultrastructural study revealed it to be neuroendocrine in nature, expressing synaptophysin, chromogranin and cytokeratin and containing dense core cytoplasmic granules.
Gene_expression (expressing) of chromogranin
10) Confidence 0.75 Published 2009 Journal Dig Endosc Section Abstract Doc Link 19691767 Disease Relevance 0.50 Pain Relevance 0.17
Immune histology demonstrated serotonin-synaptophysin-chromogranin-producing carcinoids.
Gene_expression (producing) of chromogranin associated with carcinoid and serotonin
11) Confidence 0.75 Published 2009 Journal Zentralbl Chir Section Abstract Doc Link 19757351 Disease Relevance 1.43 Pain Relevance 0.13
Immunohistochemical staining showed that the cells expressed neuroendocrine markers (synaptophysin, chromogranin, NSE) and cytokeratin marker (CAM 5.2) but were negative for S100, HMB45, CD99 and CD117.
Gene_expression (expressed) of chromogranin
12) Confidence 0.75 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 0.77 Pain Relevance 0.07
In immunostaining the original histologic material, all carcinoids expressed neuron-specific enolase, and most expressed chromogranin A, synaptophysin and serotonin.
Gene_expression (expressed) of chromogranin A in neuron associated with carcinoid and serotonin
13) Confidence 0.75 Published 1990 Journal Scand J Thorac Cardiovasc Surg Section Abstract Doc Link 2166332 Disease Relevance 1.08 Pain Relevance 0.14
Levels of CgA tend to correlate with tumour bulk but not with symptoms.
Gene_expression (Levels) of CgA associated with cancer
14) Confidence 0.75 Published 2006 Journal Current Oncology Section Body Doc Link PMC1891174 Disease Relevance 1.01 Pain Relevance 0.19
Significantly, peptide profiling provided novel insight into newly identified peptide products derived from proenkephalin, pro-NPY, proSAAS, CgA, CgB, and SCG2 prohormones.
Gene_expression (prohormones) of CgA
15) Confidence 0.65 Published 2010 Journal J. Proteome Res. Section Abstract Doc Link 20704348 Disease Relevance 0.22 Pain Relevance 0.10
One can conclude that the patients with higher CgA levels had poorer prognosis and survival, as compared to those with lower CgA levels.
Gene_expression (levels) of CgA
16) Confidence 0.65 Published 2009 Journal Arch Gerontol Geriatr Section Abstract Doc Link 18329114 Disease Relevance 0.52 Pain Relevance 0.44
Salivary CgA levels were determined using an enzyme-linked immunosorbent assay (EIA) kit (YK070 Human Chromogranin A EIA, Yanaihara Institute, Inc., Shizuoka, Japan), using the method of Yanaihara et al. [36] of Yanaihara Laboratories (Fujinomiya, Shizuoka, Japan).
Gene_expression (levels) of CgA
17) Confidence 0.65 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.12 Pain Relevance 0.06
Changes of salivary CgA
Gene_expression (Changes) of CgA
18) Confidence 0.65 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.18 Pain Relevance 0.51
The tumor cells were weakly positive for synaptophysin, chromogranin A, CD56, and NSE.
Gene_expression (positive) of chromogranin A associated with cancer
19) Confidence 0.65 Published 2006 Journal Virchows Arch. Section Abstract Doc Link 16673117 Disease Relevance 1.15 Pain Relevance 0.08
Immunohistochemical examination demonstrated that the tumor cells were positive for neuroendocrine markers, such as chromogranin, synaptophysin, and neural cell adhesion molecule (NCAM), suggesting that the lesion was a carcinoid.
Gene_expression (positive) of chromogranin in neural associated with carcinoid, cancer and adhesions
20) Confidence 0.65 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2636813 Disease Relevance 1.00 Pain Relevance 0.08

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