INT8225

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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 13.52
Pain Relevance 9.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CHGA)
Anatomy Link Frequency
chromaffin cells 6
blood 2
vesicle 2
PMNs 2
Leydig cells 1
CHGA (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 12 100.00 Very High Very High Very High
Somatostatin 6 100.00 Very High Very High Very High
Enkephalin 38 99.90 Very High Very High Very High
Catecholamine 68 99.76 Very High Very High Very High
depression 54 99.64 Very High Very High Very High
spastic colon 716 99.36 Very High Very High Very High
Neuropeptide 6 98.54 Very High Very High Very High
medulla 16 98.48 Very High Very High Very High
Inflammatory stimuli 8 98.34 Very High Very High Very High
noradrenaline 36 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pheochromocytoma 15 99.96 Very High Very High Very High
Depression 54 99.64 Very High Very High Very High
Stress 175 99.46 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

750 99.36 Very High Very High Very High
Cognitive Disorder 18 98.80 Very High Very High Very High
INFLAMMATION 52 98.18 Very High Very High Very High
Dyskinesias 9 97.72 Very High Very High Very High
Disease 43 94.44 High High
Low Back Pain 18 93.20 High High
Malignant Neoplastic Disease 6 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CgA secretion before stretching was negatively correlated with the stress score of normal subjects.
Localization (secretion) of CgA associated with stress
1) Confidence 0.78 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.79 Pain Relevance 0.98
A correlation between CgA secretion and the depression score was observed in this study.
Localization (secretion) of CgA associated with depression
2) Confidence 0.78 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.47 Pain Relevance 0.92
The changes in salivary CgA secretion resulting from exposure to a cognitive task may indicate psychological stress in humans [15].
Localization (secretion) of CgA associated with stress and cognitive disorder
3) Confidence 0.78 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.55 Pain Relevance 0.50
Interactions between period and sex of CgA secretion were not significant (F[1, 3] 2.60, p = 0.12).
Localization (secretion) of CgA
4) Confidence 0.78 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.06 Pain Relevance 0.45
In contrast, chromogranin A was present in punctate secretory granules and released via the RSP, in wild-type and CPE-depleted Neuro-2a cells.
Localization (released) of chromogranin A in Neuro-2a
5) Confidence 0.78 Published 1998 Journal Endocrinology Section Abstract Doc Link 9529003 Disease Relevance 0 Pain Relevance 0
A stress marker of the S/A system, CgA, is released in saliva due to negative feelings such as aversive stimuli and psychological stress [15,18].
Neg (negative) Localization (released) of CgA in saliva associated with stress
6) Confidence 0.78 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.73 Pain Relevance 0.37
Enkephalins, vasoactive intestinal polypeptide, and chromogranin A are all contained in the secretory vesicles of chromaffin cells in culture, and are all released from this compartment by secretagogues in a calcium-dependent way.
Localization (released) of chromogranin in chromaffin cells associated with enkephalin
7) Confidence 0.73 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3035984 Disease Relevance 0 Pain Relevance 0.35
In one patient, octreotide was commenced which resulted in normalisation of CgA and symptoms.
Localization (normalisation) of CgA
8) Confidence 0.73 Published 2009 Journal J Gastrointestin Liver Dis Section Body Doc Link 19337629 Disease Relevance 0 Pain Relevance 0
Within the pheochromocytoma, chromogranin A was localized along with catecholamines to the soluble core of chromaffin granules, where it accounted for 18 +/- 5% of vesicle soluble protein.
Localization (localized) of chromogranin A in vesicle associated with catecholamine and pheochromocytoma
9) Confidence 0.73 Published 1991 Journal Medicine (Baltimore) Section Abstract Doc Link 1988765 Disease Relevance 1.64 Pain Relevance 0.26
Thus, only profound changes in exocytotic catecholamine release from sympathetic axon LDVs would be expected to perturb circulating chromogranin A concentrations.
Localization (concentrations.) of chromogranin A in LDVs associated with catecholamine
10) Confidence 0.73 Published 1991 Journal Brain Res. Section Abstract Doc Link 1817725 Disease Relevance 0 Pain Relevance 0.34
Interactions between period and sex of CgA secretion were not shown (F[1, 3] = 2.60, p = 0.12).
Localization (secretion) of CgA
11) Confidence 0.68 Published 2008 Journal Biopsychosoc Med Section Abstract Doc Link PMC2588633 Disease Relevance 0.29 Pain Relevance 0.51
The Spearman rank correlation coefficient showed a significantly positive correlation between CgA secretion before stretching and SDS score in IBS (r = 0.51, p = 0.03) (Table 3).
Localization (secretion) of CgA associated with spastic colon
12) Confidence 0.68 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.08 Pain Relevance 0.62
CgA is a major soluble protein in adrenal medullary chromaffin granules and adrenergic neurons and is co-released with catecholamines, which are considered to be a good index of sympathetic activity [41,42].
Localization (released) of CgA in sympathetic associated with catecholamine
13) Confidence 0.68 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.31 Pain Relevance 0.75
Since enkephalin and CGA are co-stored in and co-released from the same secretory vesicles in these cells, the results imply that a surplus of CGA is constitutively synthesized in chromaffin cells such that compensatory up-regulation during changes in the secretory state of the cell, such as occurs for enkephalin, is not required for the secretory proteins.
Localization (released) of CGA in chromaffin cells associated with enkephalin
14) Confidence 0.68 Published 1992 Journal J. Physiol. Paris Section Abstract Doc Link 1364196 Disease Relevance 0 Pain Relevance 1.03
In ratings of perception and emotion, perceived stress to stretching was negatively correlated with CgA secretion in the Normal group (r = -0.66, p = 0.007).


Localization (secretion) of CgA associated with stress
15) Confidence 0.68 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.15 Pain Relevance 0.60
Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A.
Localization (secretion) of chromogranin A associated with enkephalin
16) Confidence 0.68 Published 1998 Journal Endocrinology Section Title Doc Link 9529003 Disease Relevance 0 Pain Relevance 0.20
Secretion of catestatin intermediates from chromaffin cells was accompanied by the cosecretion of catestatin (CgA(344)(-)(364)) and variant peptide forms (CgA(343)(-)(368) and CgA(332)(-)(361)).
Localization (cosecretion) of CgA in chromaffin cells
17) Confidence 0.68 Published 2003 Journal Biochemistry Section Abstract Doc Link 12795588 Disease Relevance 0 Pain Relevance 0.06
Secretion of catestatin intermediates from chromaffin cells was accompanied by the cosecretion of catestatin (CgA(344)(-)(364)) and variant peptide forms (CgA(343)(-)(368) and CgA(332)(-)(361)).
Localization (cosecretion) of CgA in chromaffin cells
18) Confidence 0.68 Published 2003 Journal Biochemistry Section Abstract Doc Link 12795588 Disease Relevance 0 Pain Relevance 0.06
Secretion of catestatin intermediates from chromaffin cells was accompanied by the cosecretion of catestatin (CgA(344)(-)(364)) and variant peptide forms (CgA(343)(-)(368) and CgA(332)(-)(361)).
Localization (cosecretion) of CgA in chromaffin cells
19) Confidence 0.68 Published 2003 Journal Biochemistry Section Abstract Doc Link 12795588 Disease Relevance 0 Pain Relevance 0.06
NE cells produce specific proteins, such as neuron specific enolase (NSE), chromograninA (CgA), bombesin, serotonin, somatostatin, a thyroid-stimulating-like peptide, parathyroid hormone-related peptides, and calcitonin which are secreted into the blood stream.
Localization (secreted) of CgA in blood associated with somatostatin and serotonin
20) Confidence 0.68 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3018395 Disease Relevance 0.93 Pain Relevance 0.10

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