INT82254

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 9.95
Pain Relevance 6.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
lung 8
neutrophil 8
macrophages 4
leukocyte 2
lumen 2
Cxcl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 174 100.00 Very High Very High Very High
cytokine 82 100.00 Very High Very High Very High
chemokine 47 100.00 Very High Very High Very High
Inflammatory mediators 45 100.00 Very High Very High Very High
Pain 25 99.52 Very High Very High Very High
Inflammation 182 99.40 Very High Very High Very High
Acute pain 2 98.32 Very High Very High Very High
dorsal root ganglion 23 98.04 Very High Very High Very High
ischemia 29 97.58 Very High Very High Very High
Dopamine 2 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 207 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 102 99.52 Very High Very High Very High
Pain 26 99.52 Very High Very High Very High
Injury 61 99.46 Very High Very High Very High
Ganglion Cysts 24 98.04 Very High Very High Very High
Urological Neuroanatomy 3 97.60 Very High Very High Very High
Cv Unclassified Under Development 23 97.58 Very High Very High Very High
Pleurisy 3 97.20 Very High Very High Very High
Lung Injury 78 97.16 Very High Very High Very High
Esophageal Disease 20 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the increased CINC-1 mRNA expression after administration of indomethacin was also inhibited by treatment with lansoprazole.
Positive_regulation (increased) of Gene_expression (expression) of CINC-1 mRNA
1) Confidence 0.69 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16328016 Disease Relevance 0.57 Pain Relevance 0.24
Fucoidin had no effect on carrageenan-induced TNF-alpha, IL-1beta, and cytokine-induced neutrophil chemoattractant 1 (CINC-1)/CXCL1 production, suggesting that neutrophils were not the source of hypernociceptive cytokines.
Positive_regulation (cytokine-induced) of Gene_expression (production) of CXCL1 in neutrophil associated with cytokine
2) Confidence 0.50 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18203872 Disease Relevance 0.46 Pain Relevance 0.31
Fucoidin had no effect on carrageenan-induced TNF-alpha, IL-1beta, and cytokine-induced neutrophil chemoattractant 1 (CINC-1)/CXCL1 production, suggesting that neutrophils were not the source of hypernociceptive cytokines.
Positive_regulation (carrageenan-induced) of Gene_expression (production) of CXCL1 in neutrophil associated with cytokine
3) Confidence 0.50 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18203872 Disease Relevance 0.46 Pain Relevance 0.31
Thus, M-5011 inhibits the production of both IL-6 and CINC-1 at lower doses than those of indomethacin, and the inhibitory effect of M-5011 on CINC-1, but not IL-6, may partly contribute to the inhibition of leukocyte infiltration in rats with MSU-induced pleurisy.
Spec (may) Positive_regulation (contribute) of Gene_expression (production) of CINC-1 in leukocyte associated with pleurisy
4) Confidence 0.48 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10361883 Disease Relevance 0.71 Pain Relevance 0.35
CONCLUSIONS: These results indicate no difference among CINC-1, -2 and -3 in the inhibition of production and mRNA expression of CINCs by anti-inflammatory steroids, although lipopolysaccharide differentially induces expression of each CINC expression in culture of rat macrophages.


Positive_regulation (induces) of Gene_expression (expression) of CINC in macrophages
5) Confidence 0.47 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: These results indicate no difference among CINC-1, -2 and -3 in the inhibition of production and mRNA expression of CINCs by anti-inflammatory steroids, although lipopolysaccharide differentially induces expression of each CINC expression in culture of rat macrophages.


Positive_regulation (induces) of Gene_expression (expression) of CINC in macrophages
6) Confidence 0.47 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0 Pain Relevance 0
This leads to prolonged mechanical pain behaviors, and a rapid increase in levels of GRO/KC and other pro-inflammatory cytokines [5] in the DRG.
Positive_regulation (increase) of Gene_expression (levels) of GRO/KC associated with dorsal root ganglion, pain, inflammation and cytokine
7) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2698898 Disease Relevance 1.37 Pain Relevance 1.03
In contrast, CXCL1 gene expression induced by 2.5 µg PDGF encapsulated in low MW and high MW PLGA microspheres had no significant differences from either the NFS alone or PDGF coating groups, which indicates up-regulation of CXCL1 gene expression stimulated by PDGF is dependent on PDGF dose.
Positive_regulation (induced) of Gene_expression (expression) of CXCL1 gene
8) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.21 Pain Relevance 0.39
In a model of chronic esophagitis due to mixed esophagogastroduodenal reflux, the protease inhibitor, camostat mesilate, significantly reduced trypsin activity in the esophageal lumen, resulting in significant suppression of the increased expression of CINC-1, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in the esophageal mucosa, as well as improvement of hyperplastic and inflammatory mucosal changes [21].
Positive_regulation (increased) of Gene_expression (expression) of CINC-1 in lumen associated with esophageal disease, inflammation and hyperplasia
9) Confidence 0.10 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.92 Pain Relevance 0.27
The upregulation of IL-6 gene expression was significantly correlated to the upregulation of IL-8, CCL2, CXCL1 and CXCL2 gene expression.
Positive_regulation (upregulation) of Gene_expression (expression) of CXCL1
10) Confidence 0.09 Published 2009 Journal Pain Section Abstract Doc Link 19233564 Disease Relevance 1.23 Pain Relevance 1.04
CINC protein expression was undetectable in the samples of saline control animals, but was markedly increased by LPS treatment for 4 hours.
Positive_regulation (increased) of Gene_expression (expression) of CINC protein
11) Confidence 0.07 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.09 Pain Relevance 0.13
CINC, MMP-9 and NO were chosen in our experiments as representative inflammatory mediators, because of their important roles in neutrophil influx and lung damage, and also because their gene regulation is dependent on NF-?
Positive_regulation (on) of Gene_expression (chosen) of CINC in lung associated with inflammatory mediators and metalloproteinase
12) Confidence 0.06 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.16 Pain Relevance 0.15
CINC, MMP-9 and NO were chosen in our experiments as representative inflammatory mediators, because of their important roles in neutrophil influx and lung damage, and also because their gene regulation is dependent on NF-?
Positive_regulation (mediators) of Gene_expression (chosen) of CINC in lung associated with inflammatory mediators and metalloproteinase
13) Confidence 0.06 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.16 Pain Relevance 0.15
CINC, MMP-9 and NO were chosen in our experiments as representative inflammatory mediators, because of their important roles in neutrophil influx and lung damage, and also because their gene regulation is dependent on NF-?
Positive_regulation (dependent) of Gene_expression (chosen) of CINC in lung associated with inflammatory mediators and metalloproteinase
14) Confidence 0.06 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.16 Pain Relevance 0.15
CINC, MMP-9 and NO were chosen in our experiments as representative inflammatory mediators, because of their important roles in neutrophil influx and lung damage, and also because their gene regulation is dependent on NF-?
Positive_regulation (experiments) of Gene_expression (chosen) of CINC in lung associated with inflammatory mediators and metalloproteinase
15) Confidence 0.06 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.16 Pain Relevance 0.15
Since the increases in production or activity of CINC, MMP-9 and NO in BAL fluid were correlated with neutrophil influx and lung injury [6,8,9,11], the inhibitory effects of JNK or ERK on production of these inflammatory mediators are functionally important, and can thus be adopted as therapeutic interventions.
Positive_regulation (increases) of Gene_expression (production) of CINC in neutrophil associated with lung injury, inflammatory mediators and metalloproteinase
16) Confidence 0.06 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.93 Pain Relevance 0.30
In renal tissues exposed to ischemia/reperfusion, neutrophil infiltration, superoxide production, TNF-alpha mRNA expression, and cytokine-induced neutrophil chemoattractant-1 mRNA expression were augmented, but these alterations were attenuated by the treatment with SA13353.
Positive_regulation (augmented) of Gene_expression (expression) of chemoattractant-1 in neutrophil associated with ischemia and cytokine
17) Confidence 0.05 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19147859 Disease Relevance 1.23 Pain Relevance 0.60
Tissue injury resulted in a significant upregulation in the gene expression of interleukin-6 (IL-6; 63.3-fold), IL-8 (8.1-fold), chemokine (C-C motif) ligand 2 (CCL2; 8.9-fold), chemokine (C-X-C motif) ligand 1 (CXCL1; 30.5-fold), chemokine (C-X-C motif) ligand 2 (CXCL2; 26-fold) and annexin A1 (ANXA1; 12-fold).
Positive_regulation (upregulation) of Gene_expression (expression) of CXCL1 associated with chemokine and injury
18) Confidence 0.05 Published 2009 Journal Pain Section Abstract Doc Link 19233564 Disease Relevance 1.15 Pain Relevance 0.90

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