INT82255

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.42
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
macrophages 2
joints 2
leukocyte 2
lung 2
Cxcl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 27 100.00 Very High Very High Very High
Chronic pancreatitis 4 99.92 Very High Very High Very High
cINOD 7 88.44 High High
fibrosis 1 88.44 High High
Inflammation 52 85.56 High High
cva 2 84.04 Quite High
addiction 10 77.00 Quite High
opioid receptor 1 75.60 Quite High
Inflammatory mediators 8 75.16 Quite High
antagonist 1 74.32 Quite High
Disease Link Frequency Relevance Heat
Cancer 6 100.00 Very High Very High Very High
Necrosis 5 100.00 Very High Very High Very High
Pancreatitis 5 99.92 Very High Very High Very High
Urological Neuroanatomy 2 97.20 Very High Very High Very High
Nociception 11 96.76 Very High Very High Very High
Pleurisy 3 92.16 High High
Fibrosis 1 88.44 High High
INFLAMMATION 66 86.28 High High
Edema 1 84.84 Quite High
Hemorrhage 2 84.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Anti-inflammatory steroids; dexamethasone, prednisolone and hydrocortisone, dose-dependently inhibited the production of CINC-1, -2 and -3, whose inhibitory patterns were similar to each other.
Negative_regulation (inhibited) of Gene_expression (production) of CINC
1) Confidence 0.58 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0.08 Pain Relevance 0
Furthermore, the increased CINC-1 mRNA expression after administration of indomethacin was also inhibited by treatment with lansoprazole.
Negative_regulation (inhibited) of Gene_expression (expression) of CINC-1 mRNA
2) Confidence 0.58 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16328016 Disease Relevance 0.52 Pain Relevance 0.24
Thus, M-5011 inhibits the production of both IL-6 and CINC-1 at lower doses than those of indomethacin, and the inhibitory effect of M-5011 on CINC-1, but not IL-6, may partly contribute to the inhibition of leukocyte infiltration in rats with MSU-induced pleurisy.
Negative_regulation (inhibits) of Gene_expression (production) of CINC-1 in leukocyte associated with pleurisy
3) Confidence 0.41 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10361883 Disease Relevance 0.71 Pain Relevance 0.35
Furthermore mRNA expression of each CINC was inhibited by dexamethasone in a dose-dependent manner.
Negative_regulation (inhibited) of Gene_expression (expression) of CINC
4) Confidence 0.38 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0.07 Pain Relevance 0
Expression of each CINC was regulated differently; the production of CINC-1 reached a maximum at 12 h and then slightly decreased after lipopolysaccharide stimulation, whereas that of CINC-2 and CINC-3 increased up to 24 h.
Negative_regulation (decreased) of Gene_expression (Expression) of CINC
5) Confidence 0.38 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0.07 Pain Relevance 0
Effects of GRO/KC are blocked by NF-?
Negative_regulation (blocked) of Gene_expression (Effects) of GRO/KC
6) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2698898 Disease Relevance 0 Pain Relevance 0.10
We hypothesize that inactivation of bacteria, as a result of topical (i.p.) application of ozone, could attenuate the migration of macrophages, decreasing CINC-1 expression at 24 h.
Negative_regulation (decreasing) of Gene_expression (expression) of CINC-1 in macrophages
7) Confidence 0.29 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827707 Disease Relevance 0.50 Pain Relevance 0.12
Furthermore, thalidomide pretreatment significantly reduced the concentration of tumor necrosis factor-alpha (TNF-alpha, -68.4%) in the exudate of zymosan-injected joints, but not those of interleukin-1beta, interleukin-6, CINC-1 or interleukin-10.
Negative_regulation (reduced) of Gene_expression (concentration) of CINC-1 in joints associated with necrosis and cancer
8) Confidence 0.28 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16597438 Disease Relevance 0.67 Pain Relevance 0.18
Our results show that IS-741 exerts a potentially therapeutic effect on experimental CP by suppressing the expressions of the proinflammatory cytokines (IL-6 and CINC) and pancreatic acute phase proteins (PAP and p8).
Negative_regulation (suppressing) of Gene_expression (expressions) of CINC associated with chronic pancreatitis and cytokine
9) Confidence 0.22 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 11837714 Disease Relevance 0.73 Pain Relevance 0.52
SP600125 or PD98059 significantly decreased the level of LPS-induced CINC expression, by 50 and 62%, respectively, in lung tissue (Figure 4A and 4Clane 3, p < 0.05) and, by 76 and 97%, respectively, in BAL fluid (Figure 4B and 4Dlane 3, p < 0.05).
Negative_regulation (decreased) of Gene_expression (expression) of CINC in lung
10) Confidence 0.07 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.07 Pain Relevance 0.14

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