INT82265

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 6.17
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lif) extracellular region (Lif)
Anatomy Link Frequency
synovial fluid 1
cartilage 1
osteoblasts 1
neurons 1
ciliary 1
Lif (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 240 100.00 Very High Very High Very High
Enkephalin 6 99.80 Very High Very High Very High
rheumatoid arthritis 166 98.88 Very High Very High Very High
Neuropathic pain 1 96.64 Very High Very High Very High
antagonist 4 95.68 Very High Very High Very High
Root ganglion neuron 5 95.04 Very High Very High Very High
imagery 2 85.76 High High
Inflammatory response 24 83.32 Quite High
Arthritis 8 79.04 Quite High
visual analogue scale 24 76.56 Quite High
Disease Link Frequency Relevance Heat
Leukemia 18 100.00 Very High Very High Very High
Rheumatoid Arthritis 177 99.80 Very High Very High Very High
Spondylolisthesis 12 99.24 Very High Very High Very High
Neuropathic Pain 1 96.64 Very High Very High Very High
Ganglion Cysts 6 94.84 High High
Disease 124 93.72 High High
INFLAMMATION 46 82.96 Quite High
Anaemia 4 82.04 Quite High
Fever 4 81.64 Quite High
Hematological Disease 10 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 family cytokines consist of IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CP-1).
Gene_expression (consist) of LIF in ciliary associated with leukemia and cytokine
1) Confidence 0.50 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.22 Pain Relevance 0.74
Measurement of IL-6, IL-11 and LIF levels
Gene_expression (levels) of LIF
2) Confidence 0.50 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 0.65 Pain Relevance 0.38
It has also been reported that LIF is found in high concentrations in cartilage and synovial fluid of patients with RA.16 IL-1 and TNF-?
Gene_expression (found) of LIF in synovial fluid associated with rheumatoid arthritis
3) Confidence 0.50 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.25 Pain Relevance 0.80
These results support the hypothesis that leukemia inhibitory factor is an important regulator of galanin/galanin message-associated peptide expression following axotomy, and may therefore be involved in the defence mechanisms against neuropathic pain at the level of dorsal root ganglion neurons.
Gene_expression (expression) of leukemia inhibitory factor in neurons associated with ganglion cysts, leukemia, root ganglion neuron and neuropathic pain
4) Confidence 0.42 Published 1999 Journal Neuroscience Section Abstract Doc Link 10362300 Disease Relevance 0.80 Pain Relevance 0.21
A new labeling method compatible with both laser-induced fluorescence (LIF) and MS detection for enkephalins, which uses naphthalene-2,3-dicarboxaldehyde (NDA) and a new nucleophilic agent (N,N-dimethylaminoethanethiol) is described.
Gene_expression (detection) of LIF associated with enkephalin
5) Confidence 0.31 Published 2007 Journal J. Am. Soc. Mass Spectrom. Section Abstract Doc Link 17689094 Disease Relevance 0 Pain Relevance 0.23
The GO-LIF fixation is not suited for spondylolisthesis reduction, which means that it can only be applied in situations of a spondylolisthesis where an in-situ fixation and fusion is planned.
Gene_expression (fixation) of GO-LIF associated with spondylolisthesis
6) Confidence 0.27 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2944216 Disease Relevance 0.25 Pain Relevance 0.04
When incubated in dbcAMP or PDGF-containing culture medium, GFAP immunolabeling was seen in 14.3-16.0% of B2A1 cells, while 10% FBS, ITS, RA, bFGF or LIF-containing medium was expressed in just 2.2-7.1% (P<0.01).
Gene_expression (expressed) of LIF associated with rheumatoid arthritis
7) Confidence 0.25 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826742 Disease Relevance 0.34 Pain Relevance 0.06
While the example shown is a GO-LIF fixation at the L5/S1 level, GO-LIF can be performed at all lumbar levels.
Gene_expression (fixation) of GO-LIF
8) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2944216 Disease Relevance 0.18 Pain Relevance 0.04
It has been previously demonstrated that osteoblasts can produce several hematopoietic cytokines including G-CSF, GM-CSF, IL-6, leukemia inhibitory factor, and stromal-derived factor 1 [44], [45].
Gene_expression (produce) of leukemia inhibitory factor in osteoblasts associated with leukemia and cytokine
9) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886847 Disease Relevance 0.23 Pain Relevance 0.09
It has also been reported that LIF is found in high concentrations in cartilage and synovial fluid of patients with RA.16 IL-1 and TNF-?
Gene_expression (found) of LIF in cartilage associated with rheumatoid arthritis
10) Confidence 0.17 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.25 Pain Relevance 0.80

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