INT82267

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Context Info
Confidence 0.40
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.76
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Lif, Gal) extracellular space (Lif) Golgi apparatus (Gal)
cytoplasm (Gal)
Anatomy Link Frequency
neurons 4
dorsal root ganglia 2
Lif (Mus musculus)
Gal (Mus musculus)
Pain Link Frequency Relevance Heat
Root ganglion neuron 15 99.00 Very High Very High Very High
Neuropathic pain 3 96.64 Very High Very High Very High
Sciatic nerve 3 95.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Leukemia 24 100.00 Very High Very High Very High
Ganglion Cysts 15 98.80 Very High Very High Very High
Neuropathic Pain 3 96.64 Very High Very High Very High
Nervous System Injury 3 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leukemia inhibitory factor regulates galanin/galanin message-associated peptide expression in cultured mouse dorsal root ganglia; with a note on in situ hybridization methodology.
Leukemia inhibitory factor Regulation (regulates) of Gene_expression (expression) of galanin in dorsal root ganglia associated with leukemia
1) Confidence 0.40 Published 1999 Journal Neuroscience Section Title Doc Link 10362300 Disease Relevance 0.90 Pain Relevance 0.20
We have therefore studied the effect of leukemia inhibitory factor on galanin expression in 72 h cultured dorsal root ganglion neurons from normal mice, leukemia inhibitory factor-deficient and heterozygous mice with immunohistochemistry and in situ hybridization.
leukemia inhibitory factor Regulation (effect) of Gene_expression (expression) of galanin in neurons associated with ganglion cysts, leukemia and root ganglion neuron
2) Confidence 0.24 Published 1999 Journal Neuroscience Section Abstract Doc Link 10362300 Disease Relevance 1.05 Pain Relevance 0.22
These results support the hypothesis that leukemia inhibitory factor is an important regulator of galanin/galanin message-associated peptide expression following axotomy, and may therefore be involved in the defence mechanisms against neuropathic pain at the level of dorsal root ganglion neurons.
leukemia inhibitory factor Regulation (regulator) of Gene_expression (expression) of galanin in neurons associated with ganglion cysts, leukemia, root ganglion neuron and neuropathic pain
3) Confidence 0.21 Published 1999 Journal Neuroscience Section Abstract Doc Link 10362300 Disease Relevance 0.80 Pain Relevance 0.21

General Comments

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