INT82278

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Context Info
Confidence 0.13
First Reported 1999
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.32
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
medial 2
striatum 2
CPu 2
nervous system 2
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 8 99.98 Very High Very High Very High
Enkephalin 11 98.94 Very High Very High Very High
Kinase C 1 98.48 Very High Very High Very High
antagonist 7 97.76 Very High Very High Very High
Dynorphin 4 95.84 Very High Very High Very High
depression 3 95.48 Very High Very High Very High
Opioid 6 92.72 High High
Pain 8 85.44 High High
long-term potentiation 4 85.36 High High
Thalamus 4 84.56 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 8 97.88 Very High Very High Very High
Depression 3 95.48 Very High Very High Very High
Cognitive Disorder 2 94.60 High High
Stress 1 93.64 High High
Nervous System Injury 10 93.04 High High
Pain 8 85.44 High High
Death 1 80.36 Quite High
Hypersensitivity 1 78.44 Quite High
Neuropathic Pain 7 75.00 Quite High
Hyperalgesia 2 70.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies from this laboratory have demonstrated that acute, systemic administration of morphine results in an induction of the immediate-early gene (IEG) proteins, c-Fos and Jun-B, in the dorsomedial portion of the rat caudate-putamen (CPu).
Positive_regulation (results) of Positive_regulation (induction) of immediate-early gene in CPu associated with morphine
1) Confidence 0.13 Published 1999 Journal Brain Res. Section Abstract Doc Link 10415375 Disease Relevance 0 Pain Relevance 0.61
Coincident stimulation of convergent cortical inputs enhances immediate early gene induction in the striatum.
Positive_regulation (enhances) of Positive_regulation (induction) of immediate early gene in striatum associated with enkephalin
2) Confidence 0.09 Published 2005 Journal Neuroscience Section Title Doc Link 15978736 Disease Relevance 0.09 Pain Relevance 0.10
Moreover, the present findings suggest that increased enkephalin expression after repeated D2 receptor antagonist treatment is an adaptive response that counteracts functional consequences of D2 receptor blockade, but is not involved in suppressed immediate-early gene induction.
Neg (not) Positive_regulation (involved) of Positive_regulation (induction) of immediate-early gene associated with antagonist and enkephalin
3) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 0.94
Recent evidence suggests that synaptic consolidation at excitatory medial perforant path-granule cell synapses requires brain-derived neurotrophic factor (BDNF) signaling and induction of the immediate early gene activity-regulated cytoskeleton-associated protein (Arc).
Positive_regulation (requires) of Positive_regulation (induction) of immediate early gene in medial associated with aids-related complex
4) Confidence 0.01 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17765733 Disease Relevance 0.78 Pain Relevance 0.29
Intracellular signal cascades result in immediate early gene (IEG) induction which is considered as the overture of a widespread change in protein synthesis, a general basis for nervous system plasticity.
Positive_regulation (result) of Positive_regulation (induction) of early gene in nervous system
5) Confidence 0.00 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11698024 Disease Relevance 1.45 Pain Relevance 0.79

General Comments

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