INT82284

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.26
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton organization (Arc)
cytoplasm (Arc)
Anatomy Link Frequency
ARC 6
Arc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 8 100.00 Very High Very High Very High
Hyperalgesia 5 100.00 Very High Very High Very High
Intracerebroventricular 4 98.94 Very High Very High Very High
drug abuse 2 95.84 Very High Very High Very High
anesthesia 17 93.96 High High
cocaine 210 92.48 High High
withdrawal 4 91.88 High High
long-term potentiation 15 66.52 Quite High
Nucleus accumbens 70 50.00 Quite Low
primary somatosensory cortex 50 48.80 Quite Low
Disease Link Frequency Relevance Heat
Aids-related Complex 293 100.00 Very High Very High Very High
Hyperalgesia 6 100.00 Very High Very High Very High
Drug Dependence 4 95.84 Very High Very High Very High
Obesity 38 75.00 Quite High
Body Weight 33 53.12 Quite High
Stress 4 48.96 Quite Low
Cognitive Disorder 15 44.48 Quite Low
Attention Deficit Hyperactivity Disorder 2 40.48 Quite Low
Weight Gain 4 32.64 Quite Low
Hyperphagia 4 12.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, IEG reinduction during REM sleep may explain the second wave of arc protein expression detected 8–24?
Negative_regulation (wave) of Gene_expression (expression) of arc protein associated with aids-related complex
1) Confidence 0.41 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.20 Pain Relevance 0
Thus, downregulation of Arc expression could be the result of CREB hypophosphorylation in control animals

[74].

Negative_regulation (downregulation) of Gene_expression (expression) of Arc associated with aids-related complex
2) Confidence 0.40 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.47 Pain Relevance 0.03
Pretreatment with the NO synthase (NOS) inhibitor, N(omega)-nitro-L-arginine methyl ester (L-NAME) attenuated the effect of capsaicin on Fos expression and NADPH-d reactivity in the ARC-ME in comparison with rats injected with D-NAME, the inactive stereoisomer of L-NAME.
Negative_regulation (attenuated) of Gene_expression (expression) of ARC-ME in ARC associated with qutenza and aids-related complex
3) Confidence 0.31 Published 1999 Journal Neuroreport Section Abstract Doc Link 10363926 Disease Relevance 0.37 Pain Relevance 0.52
Expression of the genes encoding Per2, Dbp, Arc, Egr1, Krox20 and NGFI-B was suppressed during inhalation of sevoflurane for 2 h and 6 h.
Negative_regulation (suppressed) of Gene_expression (Expression) of Arc associated with aids-related complex
4) Confidence 0.27 Published 2007 Journal Brain Res. Section Abstract Doc Link 17942082 Disease Relevance 0.10 Pain Relevance 0.70
ICV co-injection of IL-1beta with 30 ng alpha-MSH fully inhibited both hyperalgesia and Fos expression in the PVN and the ARC.
Negative_regulation (inhibited) of Gene_expression (expression) of ARC in ARC associated with hyperalgesia, aids-related complex and intracerebroventricular
5) Confidence 0.24 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16015027 Disease Relevance 0.59 Pain Relevance 0.55
We have previously described altered expression of Arc, CART, Egr1, Fos, NPY, and Nr4a1 in these samples in a directed study of genes with known relevance to drug abuse [12].
Negative_regulation (described) of Gene_expression (expression) of Arc associated with aids-related complex and drug abuse
6) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.29 Pain Relevance 0.38
We have previously described altered expression of Arc, CART, Egr1, Fos, NPY, and Nr4a1 in these samples in a directed study of genes with known relevance to drug abuse [12].
Negative_regulation (altered) of Gene_expression (expression) of Arc associated with aids-related complex and drug abuse
7) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.29 Pain Relevance 0.38
Previously, we have demonstrated that Fto is highly expressed in hypothalamic nuclei critical for regulating energy homeostasis, and that its expression within the ARC is reduced following a 48hr fast.
Negative_regulation (reduced) of Gene_expression (expression) of ARC associated with aids-related complex
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.57 Pain Relevance 0
To modulate Fto expression levels in the ARC and PVN, we generated four AAV 2/7vectors: i.)
Negative_regulation (levels) of Gene_expression (expression) of ARC associated with aids-related complex
9) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.48 Pain Relevance 0
In contrast, knocking down Arc Fto expression by 40% increases food intake by 16%. mRNA levels of Agrp, Pomc and Npy, ARC-expressed genes classically associated with the control of food intake, were not affected by the manipulation of Fto expression.
Negative_regulation (knocking) of Gene_expression (expression) of Arc in ARC associated with aids-related complex
10) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.66 Pain Relevance 0
However, upon fasting, ARC FoxO1 acetylation decreases in a Sirt1 dependent manner (Figure 4B), and Sirt1 cofactor NAD+ and Sirt1 protein levels increase (Figure 2), accounting for the increased Sirt1 activity (Figure 4A, B).
Negative_regulation (decreases) of Gene_expression (acetylation) of ARC associated with aids-related complex
11) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0

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