INT823

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Context Info
Confidence 0.58
First Reported 1978
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 144
Total Number 147
Disease Relevance 63.72
Pain Relevance 22.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
uterine 4
MCF-7 3
endometrium 3
epithelium 3
neurons 3
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 446 100.00 Very High Very High Very High
antagonist 380 100.00 Very High Very High Very High
nociceptor 64 100.00 Very High Very High Very High
tramadol 256 99.98 Very High Very High Very High
agonist 449 99.84 Very High Very High Very High
Inflammation 509 99.76 Very High Very High Very High
rheumatoid arthritis 333 99.56 Very High Very High Very High
Etanercept 285 99.40 Very High Very High Very High
Inflammatory marker 5 99.38 Very High Very High Very High
backache 42 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 517 100.00 Very High Very High Very High
Stress 397 100.00 Very High Very High Very High
Rheumatoid Arthritis 431 99.98 Very High Very High Very High
Respiratory Syncytial Virus 116 99.98 Very High Very High Very High
Breast Cancer 1782 99.92 Very High Very High Very High
Hot Flashes 161 99.84 Very High Very High Very High
Pollakiuria 1 99.80 Very High Very High Very High
Cancer 1519 99.76 Very High Very High Very High
INFLAMMATION 527 99.76 Very High Very High Very High
Apoptosis 874 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If they do, the mechanism is not the same as that of the endometrium [down-regulation of ER, increase of 17 beta-hydroxysteroid dehydrogenase activity (E2DH)].
Negative_regulation (down-regulation) of ER in endometrium
1) Confidence 0.58 Published 1995 Journal Arch. Anat. Cytol. Pathol. Section Abstract Doc Link 7794024 Disease Relevance 0.41 Pain Relevance 0.09
In both treatment groups a statistically significant decrease in the number of painful and/or swollen joints, an increase in haemoglobin and a decrease in ESR, serum ceruloplasmin-, alpha1-acid glycoprotein-, IgG-, IgM- and IgA levels was observed.
Negative_regulation (decrease) of ESR in joints associated with pain
2) Confidence 0.57 Published 1978 Journal Scand. J. Rheumatol. Section Abstract Doc Link 103190 Disease Relevance 0.16 Pain Relevance 0.22
Conservative treatment should be limited to these cases, where we can see a quick recovery, reducing of the pain and decreasing of the level of CRP and ESR.
Negative_regulation (reducing) of ESR associated with pain
3) Confidence 0.57 Published 2002 Journal Chir Narzadow Ruchu Ortop Pol Section Abstract Doc Link 12087677 Disease Relevance 0.36 Pain Relevance 0.10
An acute time-course experiment indicated that the downregulation of ER?
Negative_regulation (downregulation) of ER
4) Confidence 0.54 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.04
The ability for decursin and DA to downregulate ER?
Negative_regulation (downregulate) of ER
5) Confidence 0.47 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.06
Faslodex¬ô (Figure 4c, lanes 6 and 7) effectively decreased ER?
Negative_regulation (decreased) of ER
6) Confidence 0.47 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.10
Combined, these data suggest that decursin can downregulate ER?
Negative_regulation (downregulate) of ER
7) Confidence 0.47 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.08 Pain Relevance 0
Decursin shares some mechanisms of actions with Faslodex¬ô, including a downregulation of the ER?
Negative_regulation (downregulation) of ER
8) Confidence 0.47 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.26 Pain Relevance 0.17
PRF-IMEM with 5% charcoal-stripped FBS (Atlanta Biologicals) without insulin was then added for estrogen deprivation.
Negative_regulation (deprivation) of estrogen
9) Confidence 0.47 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.21 Pain Relevance 0
In MCF-7 cells, the agents' effects on the cell cycle and apoptosis were associated with decreased ER?
Negative_regulation (decreased) of ER in MCF-7 associated with apoptosis
10) Confidence 0.47 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.60 Pain Relevance 0
Based on expected steroid receptor changes, the loss of ER during the mid-secretory phase provides a time in the cycle when mitoses cease and implantation occurs.
Negative_regulation (loss) of ER
11) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0.14 Pain Relevance 0
After treatment, TGF-beta1 increased, while TNF-alpha, CRP and ESR decreased in group II (P < 0.01).
Negative_regulation (decreased) of ESR
12) Confidence 0.42 Published 2008 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19317165 Disease Relevance 0.06 Pain Relevance 0
Conservative treatment should be limited to these cases, where we can see a quick recovery, reducing of the pain and decreasing of the level of CRP and ESR.
Negative_regulation (decreasing) of ESR associated with pain
13) Confidence 0.42 Published 2002 Journal Chir Narzadow Ruchu Ortop Pol Section Abstract Doc Link 12087677 Disease Relevance 0.36 Pain Relevance 0.10
In contrast to the lack of any impact by decursin or DA on the AR mRNA level in LNCaP cells [26,27], however, a sharp and rapid downregulation of ER?
Negative_regulation (downregulation) of ER
14) Confidence 0.40 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.38 Pain Relevance 0.06
The growth inhibitory effects involved common pathways such as the inactivation of the mitogen signaling ERK1/2, as well as distinct targets such as ER?
Negative_regulation (inactivation) of ER
15) Confidence 0.40 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.44 Pain Relevance 0.05
Furthermore, we observed a downregulation of the estrogen receptor ?
Negative_regulation (downregulation) of estrogen receptor
16) Confidence 0.39 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.60 Pain Relevance 0
In contrast, the treatment with the aglycon mixture caused a marginally stronger up- or downregulation of some genes, such as CCNE2, DNAJB9, E2F2, ESR1 and GADD45A.
Negative_regulation (downregulation) of ESR1
17) Confidence 0.39 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.23 Pain Relevance 0
In contrast, among genes downregulated in ER- ERBB2-amplified tumors (p < 0.05), some coded for proteins involved in endothelin-1 signaling, nitric oxide signaling in the cardiovascular system (both associated with cardiovascular signaling pathways), NRF2-mediated oxidative stress response (cell stress and injury pathway), synaptic long term depression, neuropathic pain signaling in dorsal horns neurons, mechanisms of viral exit from host cells and other metabolic pathways.


Negative_regulation (downregulated) of ER in neurons associated with stress, depression, cancer, injury and neuropathic pain
18) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 1.40 Pain Relevance 0.19
Apart from ESR1, which was downregulated with E2 and black cohosh treatment (Figure 8), and VEGF, which can be considered to be regulated via hypoxia response pathways, no gene affected by black cohosh is known to contain estrogen responsive elements (ERE) in the promoter region.


Negative_regulation (downregulated) of ESR1 associated with hypoxia
19) Confidence 0.39 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.37 Pain Relevance 0
We suspect that there will be many genes other than beta 3 integrin subunit that are regulated in concert during implantation in response to EGF and the loss of ER-alpha.
Negative_regulation (loss) of ER
20) Confidence 0.38 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0.58 Pain Relevance 0.10

General Comments

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