INT82305

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.00
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
neurons 4
microglia 4
spinal 2
nerve 2
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 100.00 Very High Very High Very High
IPN 2 99.64 Very High Very High Very High
c fibre 1 99.18 Very High Very High Very High
Glutamate receptor 3 98.72 Very High Very High Very High
Calcium channel 6 98.52 Very High Very High Very High
antagonist 9 97.40 Very High Very High Very High
Sciatic nerve 4 97.20 Very High Very High Very High
Pain 4 96.88 Very High Very High Very High
Dorsal horn 9 96.72 Very High Very High Very High
Spinal cord 11 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 7 100.00 Very High Very High Very High
Inflammatory Pain 2 99.64 Very High Very High Very High
Pain 14 96.88 Very High Very High Very High
Anaerobic Bacterial Infections 3 93.68 High High
Hypersensitivity 9 92.56 High High
Injury 4 91.64 High High
INFLAMMATION 4 90.24 High High
Nervous System Injury 7 83.28 Quite High
Lumbar Puncture Related Headaches 1 46.32 Quite Low
Ganglion Cysts 2 36.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both phases of BDNF release and the accumulation within the microglia are dependent on extracellular Ca(2+).
Regulation (dependent) of Localization (release) of BDNF in microglia
1) Confidence 0.40 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295157 Disease Relevance 0.47 Pain Relevance 0.23
Furthermore, we find that the P2X4R-evoked release and synthesis of BDNF are dependent on activation of p38-mitogen-activated protein kinase (MAPK).
Regulation (dependent) of Localization (release) of BDNF
2) Confidence 0.40 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295157 Disease Relevance 0.42 Pain Relevance 0.24
The dual requirement for calcium influx through N-type calcium channels and calcium mobilization from intracellular stores strongly implicates a role for calcium-induced calcium release in activity-dependent BDNF secretion.
Regulation (role) of Localization (secretion) of BDNF associated with calcium channel
3) Confidence 0.39 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451139 Disease Relevance 0.07 Pain Relevance 0.22
We further suggest that the endogenous release of GDNF and BDNF, triggered by nociceptive stimuli, is involved in the induction of changes in spinal nociceptive transmission as in various pain states.
Regulation (involved) of Localization (release) of BDNF in spinal associated with nociception and pain
4) Confidence 0.37 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15899262 Disease Relevance 0.46 Pain Relevance 0.46
In relation to this, P2X7 receptors are responsible for BDNF release from Schwann cells, which display neuroprotective actions on neighbouring vestibular neurons [32].
Regulation (responsible) of Localization (release) of BDNF in neurons
5) Confidence 0.34 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.08 Pain Relevance 0.15
We also show directly that inflammatory pain-related behavior depends on BDNF release in vivo.
Regulation (depends) of Localization (release) of BDNF associated with ipn
6) Confidence 0.27 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10366647 Disease Relevance 0.75 Pain Relevance 0.86
Electrical stimulation of the ipsilateral sciatic nerve at a strength adequate to excite either A fibres (20 Hz at 2x threshold voltage) or A and C fibres (2 Hz at 20x threshold voltage) did not alter the basal release of immunoreactive BDNF in normal or in nerve-injured rats.
Neg (not) Regulation (alter) of Localization (release) of BDNF in nerve associated with c fibre and sciatic nerve
7) Confidence 0.24 Published 2001 Journal Brain Res. Section Abstract Doc Link 11311885 Disease Relevance 0 Pain Relevance 0.52
Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons.
Regulation (regulating) of Localization (release) of brain-derived neurotrophic factor in neurons
8) Confidence 0.24 Published 2002 Journal J. Neurosci. Section Title Doc Link 12451139 Disease Relevance 0.06 Pain Relevance 0.21
Each stimulation protocol resulted in a significant increase in BDNF release that was tetrodotoxin sensitive and occurred in the absence of glutamate receptor activation.
Regulation (sensitive) of Localization (release) of BDNF associated with tetrodotoxin and glutamate receptor
9) Confidence 0.24 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451139 Disease Relevance 0.09 Pain Relevance 0.30
P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation.
Regulation (dependent) of Localization (release) of brain-derived neurotrophic factor in microglia
10) Confidence 0.21 Published 2009 Journal J. Neurosci. Section Title Doc Link 19295157 Disease Relevance 0.53 Pain Relevance 0.27
Nevertheless, it cannot be excluded that this type of cross-mechanisms could take place in more physiological conditions, taking into account that some precedents are found in recent interesting works regarding the effect of nucleotide receptors in both BDNF expression and release.
Regulation (effect) of Localization (release) of BDNF
11) Confidence 0.17 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.08 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox