INT82308

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Context Info
Confidence 0.38
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.52
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (HADHA) small molecule metabolic process (HADHA) lyase activity (HADHA)
oxidoreductase activity (HADHA) nucleolus (HADHA) cytoplasm (HADHA)
HADHA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 98.84 Very High Very High Very High
cINOD 8 97.80 Very High Very High Very High
Potency 1 97.12 Very High Very High Very High
peripheral neuropathy 2 94.64 High High
Pain 2 94.20 High High
Disease Link Frequency Relevance Heat
Colon Cancer 4 98.08 Very High Very High Very High
Peripheral Neuropathy 2 94.64 High High
Pain 2 94.20 High High
Muscle Weakness 2 93.84 High High
Ocular Toxicity (including Many Sub-types) 2 91.92 High High
Coronary Heart Disease 2 88.96 High High
INFLAMMATION 2 86.72 High High
Disease 2 81.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seventy-six per cent of patients with disorders of the mitochondrial trifunctional protein (TFP)-complex including long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency, had long-term myopathic symptoms.
Negative_regulation (deficiency) of LCHAD
1) Confidence 0.38 Published 2009 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 19399638 Disease Relevance 0.54 Pain Relevance 0.14
The good correlation observed between the potency of NSAIDs as inhibitors of colorectal carcinoma cell proliferation and as antagonists of a 78 kDa gastrin binding protein (GBP) suggested that blockade of the GBP might contribute to the anti-proliferative effects of NSAIDs [G.S.
Negative_regulation (blockade) of GBP associated with antagonist, colon cancer, cinod and potency
2) Confidence 0.34 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10366761 Disease Relevance 0.44 Pain Relevance 0.63
Seventy-six per cent of patients with disorders of the mitochondrial trifunctional protein (TFP)-complex including long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency, had long-term myopathic symptoms.
Negative_regulation (deficiency) of long-chain 3-hydroxyacyl-CoA dehydrogenase
3) Confidence 0.33 Published 2009 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 19399638 Disease Relevance 0.55 Pain Relevance 0.14

General Comments

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