INT8232

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 27
Disease Relevance 22.18
Pain Relevance 12.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joint 3
endothelial cells 2
neurons 2
plasma 1
spinal cord 1
Paf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 241 100.00 Very High Very High Very High
agonist 37 99.82 Very High Very High Very High
antagonist 144 99.78 Very High Very High Very High
dorsal root ganglion 658 99.68 Very High Very High Very High
cytokine 324 99.48 Very High Very High Very High
Crohn's disease 8 98.64 Very High Very High Very High
antiallodynic 3 98.62 Very High Very High Very High
withdrawal 105 98.44 Very High Very High Very High
Spinal cord 54 98.04 Very High Very High Very High
Brush evoked pain 344 98.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 299 100.00 Very High Very High Very High
Injury 88 99.88 Very High Very High Very High
Disorder Of Lipid Metabolism 425 99.76 Very High Very High Very High
Ganglion Cysts 665 99.68 Very High Very High Very High
Apoptosis 136 99.16 Very High Very High Very High
Endotoxemia 107 99.16 Very High Very High Very High
Disease 83 98.32 Very High Very High Very High
Adhesions 28 98.04 Very High Very High Very High
Neuropathic Pain 474 98.02 Very High Very High Very High
Nervous System Injury 406 97.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A kinetic study revealed that PAF-mediated protection of mice form lethal endotoxemia was substantially reduced when PAF treatment was delayed up to 3 h post-LPS injection (Figure 1C).
Gene_expression (protection) of PAF-mediated associated with endotoxemia
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.15 Pain Relevance 0.08
Interestingly, IL-10, an anti-inflammatory cytokine, was notably elevated by PAF treatment in LPS-challenged mice (Figure 2A)
Gene_expression (treatment) of PAF associated with inflammation and cytokine
2) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.47 Pain Relevance 0.59
Collectively, the present findings suggest that niranthin exhibits antiinflammatory and antiallodynic actions which are probably mediated through its direct antagonistic action on the PAF receptor binding sites.
Gene_expression (action) of PAF associated with inflammation and antiallodynic
3) Confidence 0.66 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16925995 Disease Relevance 0.47 Pain Relevance 0.34
The expression of PAF receptor mRNA by RT-PCR was observed in DRG and spinal cord in mice.
Gene_expression (expression) of PAF in spinal cord associated with spinal cord
4) Confidence 0.64 Published 2004 Journal Pain Section Abstract Doc Link 15363879 Disease Relevance 1.01 Pain Relevance 1.40
We already identified that PAF-R expression in DCs was induced by LPS or PAF (Figure S2).
Gene_expression (expression) of PAF
5) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.37 Pain Relevance 0.31
These findings indicate that the protective effect of PAF against LPS lethality results from a marked decrease in all characteristic of severe tissue injury in LPS-induced endotoxemia.
Gene_expression (effect) of PAF associated with endotoxemia and injury
6) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 1.06 Pain Relevance 0.03
PAF protects against lymphocytes apoptosis
Gene_expression (protects) of PAF in lymphocytes associated with apoptosis
7) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 1.19 Pain Relevance 0
Administration of PAF attenuated LPS-induced organ injury
Gene_expression (attenuated) of PAF associated with injury
8) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.45 Pain Relevance 0.27
Therefore, cPAF administration was also resistant to LPS-induced lethality (Figure 1D).


Gene_expression (resistant) of cPAF
9) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.43 Pain Relevance 0.31
We report the presence of PAF in stool of patients with active Crohn's disease (39.1 +/- 13.5 ng/g of stool, mean +/- SEM, N = 19) and its absence in patients with irritable bowel syndrome with diarrhea and diarrhea with malabsorption.
Gene_expression (presence) of PAF in bowel associated with diarrhoea, crohn's disease, spastic colon and disease
10) Confidence 0.58 Published 1992 Journal Dig. Dis. Sci. Section Abstract Doc Link 1735366 Disease Relevance 0.74 Pain Relevance 0.29
They would warrant to investigate the influence of various therapeutic agents, including PAF antagonists, on fecal PAF levels during inflammatory digestive ailments.
Gene_expression (levels) of PAF associated with inflammation and antagonist
11) Confidence 0.58 Published 1992 Journal Dig. Dis. Sci. Section Abstract Doc Link 1735366 Disease Relevance 0.95 Pain Relevance 0.45
Castor oil increases the induction of prostaglandins [23], causes changes in the permeability and mucosal injuries and stimulates PAF [24] biosynthesis which may result in inflammation of intestinal mucosa.
Gene_expression (biosynthesis) of PAF associated with inflammation and injury
12) Confidence 0.23 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1249555 Disease Relevance 0.59 Pain Relevance 0.05
First, we examined whether DRG neurons with activated cPLA2 express the lyso-PAF-acetyltransferase LPCAT2, a critical enzyme that produces PAF [32], [33], [34].
Gene_expression (produces) of PAF in neurons associated with dorsal root ganglion
13) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.43 Pain Relevance 0.86
Furthermore, DRG neurons with activated cPLA2 also expressed the lyso-PAF-acetyltransferase LPCAT2, a critical enzyme that produces PAF [32], [33], [34].
Gene_expression (produces) of PAF in neurons associated with dorsal root ganglion
14) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.71 Pain Relevance 1.22
Because a mechanism underlying LPAR-mediated tactile allodynia has been previously demonstrated [12], [31], in the present study we investigated the role of the PAF-PAFR system in the DRG.
Gene_expression (system) of PAF associated with dorsal root ganglion and brush evoked pain
15) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.49 Pain Relevance 0.97
To determine the role of lysophospholipid-derived lipid mediators such as PAF and LPA in nerve injury-induced tactile allodynia, we administered PAFR and LPA receptor (LPAR) antagonists to nerve-injured rats because inhibitors of PAF and LPA biosynthetic enzymes are not available.
Gene_expression (biosynthetic) of PAF in nerve associated with brush evoked pain, nervous system injury and antagonist
16) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.05 Pain Relevance 0.88
HDL-C inhibits PAF production by endothelial cells in dose-dependent manner (Sugatani et al 1996) via hydrolysis of acetyl residues mediated by PAFAH.
Gene_expression (production) of PAF in endothelial cells associated with disorder of lipid metabolism
17) Confidence 0.16 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.42 Pain Relevance 0.13
The threshold began to decrease 15 min after PAF injection and peaked at 45–60 min, then gradually recovered over 4 h (Fig. 9A).
Gene_expression (injection) of PAF
18) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.12 Pain Relevance 0.88
These results suggest that administering PAF near the DRG causes a decrease in the withdrawal threshold and production of TNF?
Gene_expression (administering) of PAF associated with dorsal root ganglion and withdrawal
19) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.12 Pain Relevance 0.85
was increased 45 min after PAF injection (Fig. 9C, D), when the threshold was markedly reduced.
Gene_expression (injection) of PAF
20) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.01 Pain Relevance 0.83

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