INT8233

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Context Info
Confidence 0.49
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.76
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joint 4
Paf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 29 100.00 Very High Very High Very High
antiallodynic 3 99.44 Very High Very High Very High
b2 receptor 3 98.00 Very High Very High Very High
antagonist 23 97.04 Very High Very High Very High
dorsal root ganglion 94 96.44 Very High Very High Very High
Analgesic 6 94.08 High High
withdrawal 15 90.60 High High
allodynia 7 90.48 High High
cINOD 2 78.88 Quite High
cytokine 43 76.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 38 100.00 Very High Very High Very High
Injury 11 100.00 Very High Very High Very High
Endotoxemia 15 99.96 Very High Very High Very High
Apoptosis 18 97.20 Very High Very High Very High
Ganglion Cysts 95 96.44 Very High Very High Very High
Hypotension 6 95.72 Very High Very High Very High
Arthropathy 2 95.64 Very High Very High Very High
Sepsis 15 93.84 High High
Septic Shock 22 90.80 High High
Neuropathic Pain 68 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, the present findings suggest that niranthin exhibits antiinflammatory and antiallodynic actions which are probably mediated through its direct antagonistic action on the PAF receptor binding sites.
Positive_regulation (mediated) of Gene_expression (action) of PAF associated with inflammation and antiallodynic
1) Confidence 0.49 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16925995 Disease Relevance 0.48 Pain Relevance 0.37
These findings indicate that the protective effect of PAF against LPS lethality results from a marked decrease in all characteristic of severe tissue injury in LPS-induced endotoxemia.
Positive_regulation (induced) of Gene_expression (effect) of PAF associated with endotoxemia and injury
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 1.10 Pain Relevance 0.03
was increased 45 min after PAF injection (Fig. 9C, D), when the threshold was markedly reduced.
Positive_regulation (increased) of Gene_expression (injection) of PAF
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.02 Pain Relevance 0.83
Kinins also stimulate the synthesis of other pro-inflammatory agents (PGs, LTs, histamine, EDRF, PGI2 and PAF) in the inflamed joint.
Positive_regulation (stimulate) of Gene_expression (synthesis) of PAF in joint associated with inflammation
4) Confidence 0.05 Published 1991 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 1365470 Disease Relevance 0.54 Pain Relevance 0.45
Kinins also stimulate the synthesis of other pro-inflammatory agents (PGs, LTs, histamine, EDRF, PGI2 and PAF) in the inflamed joint.
Positive_regulation (stimulate) of Gene_expression (synthesis) of PAF in joint associated with inflammation
5) Confidence 0.04 Published 1991 Journal Pharmacol. Res. Section Abstract Doc Link 1648214 Disease Relevance 0.62 Pain Relevance 0.56

General Comments

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