INT82354

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Context Info
Confidence 0.34
First Reported 1998
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 22.93
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1)
plasma membrane (PECAM1)
Anatomy Link Frequency
endothelium 2
plasma 1
lymphocytes 1
extracellular matrix 1
epithelium 1
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 294 100.00 Very High Very High Very High
cytokine 153 99.90 Very High Very High Very High
Multiple sclerosis 328 99.84 Very High Very High Very High
rheumatoid arthritis 19 98.48 Very High Very High Very High
chemokine 225 98.26 Very High Very High Very High
metalloproteinase 87 97.56 Very High Very High Very High
Arthritis 105 96.92 Very High Very High Very High
depression 45 96.52 Very High Very High Very High
endometriosis 72 91.76 High High
alcohol 3 90.24 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 323 100.00 Very High Very High Very High
Adhesions 203 100.00 Very High Very High Very High
Multiple Sclerosis 372 99.84 Very High Very High Very High
Coronary Artery Disease 43 99.84 Very High Very High Very High
Disease 219 99.82 Very High Very High Very High
Diabetes Mellitus 7 99.82 Very High Very High Very High
Recurrence 14 99.44 Very High Very High Very High
Psoriasis 45 99.24 Very High Very High Very High
Rheumatoid Arthritis 19 98.48 Very High Very High Very High
Injury 82 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further investigation of involvement of the intercellular adhesion molecules 1 and 2, platelet endothelial cell adhesion molecule, vascular cell adhesion molecule and E-selectin in leukocyte accumulation will be needed to support the passage of maternal cells to the foetus.
Positive_regulation (involvement) of platelet endothelial cell adhesion molecule in platelet associated with adhesions
1) Confidence 0.34 Published 2006 Journal Clin. Exp. Med. Section Abstract Doc Link 17191109 Disease Relevance 0.37 Pain Relevance 0
m section that contained lesions of interest was prepared to hematoxylin and eosin-staining and CD31 and CD105 immunohistochemistry staining for analysis.
Positive_regulation (staining) of CD31
2) Confidence 0.25 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267739 Disease Relevance 0.11 Pain Relevance 0.05
Similar results were obtained for the CD31-FITC labeled cells (Figure 4).
Positive_regulation (results) of CD31-FITC
3) Confidence 0.24 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.13 Pain Relevance 0
From these results, for both CD31 and CD34, the median MVD was higher in the older group of patients.
Positive_regulation (higher) of CD31
4) Confidence 0.20 Published 2006 Journal Int Semin Surg Oncol Section Body Doc Link PMC1435760 Disease Relevance 0.20 Pain Relevance 0
Immunohistochemistry staining was strongly and diffusely positive for vascular endothelial markers (CD31, CD34) (Figure 2b) and for vimentin.
Positive_regulation (positive) of CD31
5) Confidence 0.19 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2567320 Disease Relevance 1.24 Pain Relevance 0.04
In 2005, another study documented increased sPECAM-1 during acute relapse and in remission compared with progression [311].
Positive_regulation (increased) of sPECAM-1 associated with recurrence
6) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 1.20 Pain Relevance 0.27
It was reported in 1999 that levels of serum soluble PECAM-1 (sPECAM-1) are significantly elevated in patients with active, gadolinium-enhancing lesions [309].
Positive_regulation (elevated) of sPECAM-1
7) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 1.33 Pain Relevance 0.30
In 2001, we reported that PECAM-1-positive endothelial microparticles (EMP) are elevated in MS patients only during relapses, and correlated well with gadolinium-enhancing lesions [310].
Positive_regulation (elevated) of PECAM-1-positive associated with multiple sclerosis and recurrence
8) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 1.31 Pain Relevance 0.31
It was reported in 1999 that levels of serum soluble PECAM-1 (sPECAM-1) are significantly elevated in patients with active, gadolinium-enhancing lesions [309].
Positive_regulation (elevated) of PECAM-1
9) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 1.33 Pain Relevance 0.30
In the present study, non-survivors (in comparison with survivors) showed elevated adhesion molecule levels over the whole study period.
Positive_regulation (elevated) of adhesion molecule associated with adhesions
10) Confidence 0.07 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 1.38 Pain Relevance 0
3 integrin is an adhesion molecule that is upregulated in new vessel proliferation in response to angiogenic stimuli, while it is not expressed or only at low levels in resting endothelium [67].
Positive_regulation (upregulated) of adhesion molecule in endothelium associated with adhesions
11) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2955663 Disease Relevance 0.95 Pain Relevance 0
After a comparable course at different levels in the first 2 days, non-survivors had an increase in adhesion molecule concentrations whereas survivors' adhesion molecule levels decreased markedly.
Positive_regulation (increase) of adhesion molecule associated with adhesions
12) Confidence 0.05 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 0.70 Pain Relevance 0
For example, cutaneous lymphocyte associated (CLA) antigen, an adhesion molecule that identifies lymphocytes that preferentially traffic to the skin, is upregulated on lymphocytes in psoriatic skin but is minimally expressed on cells in the PsA synovium [36].


Positive_regulation (upregulated) of adhesion molecule in lymphocytes associated with psoriasis, adhesions and arthritis
13) Confidence 0.04 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.26 Pain Relevance 0.51
Experimental studies show widespread microvascular endothelial activation [20,63] with upregulated adhesion molecule expression within 2-4 hours of neurological injury [24,64].
Positive_regulation (upregulated) of adhesion molecule associated with injury and adhesions
14) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.78 Pain Relevance 0.11
Lastly, the intercellular adhesion molecule, ICAM-1, a cluster B gene, was previously found to be increased on inflamed airway epithelium in a primate model of pulmonary inflammation [34].
Positive_regulation (increased) of adhesion molecule in epithelium associated with inflammation, pneumonia and adhesions
15) Confidence 0.03 Published 2002 Journal Genome Biol Section Body Doc Link PMC115222 Disease Relevance 0.47 Pain Relevance 0.16
To our knowledge the effect of

CVVHD on the important adhesion molecules CD11a, CD11b, CD18 and CD44 has not been investigated before.

Positive_regulation (important) of adhesion associated with adhesions
16) Confidence 0.02 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 1.05 Pain Relevance 0
Two families of adhesion

molecules are necessary for the adhesion and migration of granulocytes through endothelium into tissues, namely the integrin and the selectin family.

Positive_regulation (necessary) of adhesion in endothelium associated with adhesions
17) Confidence 0.02 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 0.98 Pain Relevance 0.18
can induce intercellular adhesion molecule (ICAM)-1 expression.
Positive_regulation (induce) of adhesion molecule associated with adhesions
18) Confidence 0.02 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 0.84 Pain Relevance 0.19
Sulfasalazine (also as a representative of the salicylates) inhibited the diabetes-induced upregulation of several inflammatory gene products, which are regulated by NF-kappaB, including vascular cell adhesion molecule, intracellular adhesion molecule-1, inducible nitric oxide synthase, and cyclooxygenase-2 in whole-retinal lysate.
Positive_regulation (upregulation) of adhesion molecule associated with inflammation, diabetes mellitus and adhesions
19) Confidence 0.01 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.21 Pain Relevance 0.16
Chemokines also have non-immune functions during tissue remodelling and in many diseases through upregulation of adhesion molecule expression, angiogenesis, cell proliferation and motility [59].
Positive_regulation (upregulation) of adhesion molecule associated with chemokine, disease and adhesions
20) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 1.14 Pain Relevance 0.64

General Comments

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