INT82366

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
lymphocyte 2
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 5 100.00 Very High Very High Very High
fluoxetine 6 99.98 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that fluoxetine promoted the Ca2+ -mediated proteolysis of protein kinase C (PKC) and increased cyclic-AMP (cAMP) levels, thereby impairing lymphocyte proliferation, when optimal concanavalin A concentrations were used.
Positive_regulation (promoted) of Protein_catabolism (proteolysis) of PKC in lymphocyte associated with kinase c and fluoxetine
1) Confidence 0.49 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374716 Disease Relevance 0 Pain Relevance 0.73

General Comments

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