INT8237

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 4.41
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Kng1) extracellular region (Kng1)
Anatomy Link Frequency
plasma 4
hypothalamus 2
carotid artery 2
hypophysis 1
Uterine 1
Kng1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 6 98.96 Very High Very High Very High
Inflammatory response 5 94.80 High High
Inflammation 30 93.88 High High
bradykinin 22 92.64 High High
Chronic pancreatitis 5 92.08 High High
anesthesia 6 91.84 High High
cINOD 4 75.00 Quite High
Dismenorea 5 70.24 Quite High
b2 receptor 1 67.20 Quite High
antagonist 1 66.24 Quite High
Disease Link Frequency Relevance Heat
Cancer 5 100.00 Very High Very High Very High
Injury 20 99.64 Very High Very High Very High
Hypoalbuminemia 6 99.64 Very High Very High Very High
Experimental Arthritis 5 98.96 Very High Very High Very High
Pancreatic Cancer 7 96.16 Very High Very High Very High
Disorder Of Lipid Metabolism 2 95.28 Very High Very High Very High
INFLAMMATION 38 94.80 High High
Frailty 2 93.36 High High
Arthropathy 1 93.36 High High
Apoptosis 2 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Uterine LMW kininogen levels were elevated on day 21, followed by a marked fall on day 22.
Positive_regulation (elevated) of Uterine LMW kininogen in Uterine
1) Confidence 0.69 Published 1995 Journal Endocrinology Section Abstract Doc Link 7828557 Disease Relevance 0 Pain Relevance 0.16
This elevation on day 21 was due to increased T- and LMW kininogen levels.
Positive_regulation (increased) of LMW kininogen
2) Confidence 0.69 Published 1995 Journal Endocrinology Section Abstract Doc Link 7828557 Disease Relevance 0 Pain Relevance 0.15
Neither the hypophysis, nor the adrenals seem to be involved in mediating the increase in T-kininogen.
Positive_regulation (increase) of kininogen in hypophysis
3) Confidence 0.63 Published 1987 Journal Agents Actions Suppl. Section Abstract Doc Link 3481211 Disease Relevance 0.17 Pain Relevance 0
Total kininogen levels in the hypothalamus were undetectable during pregnancy; however, anterior pituitary kininogen levels increased markedly from days 15-22.
Positive_regulation (increased) of kininogen in hypothalamus
4) Confidence 0.60 Published 1995 Journal Endocrinology Section Abstract Doc Link 7828557 Disease Relevance 0 Pain Relevance 0.06
The results indicate that surgical trauma induces a marked increase in the concentration of T-kininogen in rat plasma.
Positive_regulation (increase) of kininogen in plasma associated with injury
5) Confidence 0.46 Published 1987 Journal Agents Actions Suppl. Section Abstract Doc Link 3481211 Disease Relevance 0.17 Pain Relevance 0
The effect of adjuvant arthritis (AA) on the pattern of rat serum proteins includes the upregulation of haptoglobin, orosomucoid, alpha2-macroglobulin, serine protease inhibitor-3, thiostatin, alpha1-antitrypsin, C-reactive protein, and the downregulation of kallikrein-binding protein, alpha1-inhibitor III, apolipoprotein A-I, alpha2-HS-glycoprotein, albumin, apolipoprotein A-IV, transthyretin and transferrin.
Positive_regulation (upregulation) of thiostatin associated with experimental arthritis, disorder of lipid metabolism and arthritis
6) Confidence 0.41 Published 2000 Journal Electrophoresis Section Abstract Doc Link 10892728 Disease Relevance 0.80 Pain Relevance 0.34
This rise was due to increases primarily in T-kininogen compared to low mol wt (LMW) kininogen.
Positive_regulation (increases) of kininogen
7) Confidence 0.40 Published 1995 Journal Endocrinology Section Abstract Doc Link 7828557 Disease Relevance 0 Pain Relevance 0.03
Total kininogen levels in the hypothalamus were undetectable during pregnancy; however, anterior pituitary kininogen levels increased markedly from days 15-22.
Positive_regulation (increased) of kininogen in hypothalamus
8) Confidence 0.40 Published 1995 Journal Endocrinology Section Abstract Doc Link 7828557 Disease Relevance 0 Pain Relevance 0.06
The increase in kininogen was proportional to the extent of the surgery since simple exposure of the carotid artery increased kininogen to 5.3 +/- 0.5 micrograms bk eq/ml, and sham carotid cannulation to 8.3 +/- 0.4 micrograms bk eq/ml.
Positive_regulation (increase) of kininogen in carotid artery
9) Confidence 0.37 Published 1987 Journal Agents Actions Suppl. Section Abstract Doc Link 3481211 Disease Relevance 0.07 Pain Relevance 0.12
Plasma kininogen is known to increase after nephrectomy in the rat, and we studied the type of kininogen responsible for the increase.
Positive_regulation (increase) of kininogen in Plasma
10) Confidence 0.37 Published 1987 Journal Agents Actions Suppl. Section Abstract Doc Link 3481211 Disease Relevance 0.07 Pain Relevance 0.04
However, we found that the increase in total kininogen was not due to nephrectomy per se, but rather to surgery, since similar increases were found after 24 hours in shamnephrectomized rats (15.5 +/- 0.5 micrograms bk eq/ml), and in rats with a catheter implanted into the carotid artery (14.2 +/- 1.7 micrograms bk eq/ml).
Positive_regulation (increase) of kininogen in 14.2
11) Confidence 0.37 Published 1987 Journal Agents Actions Suppl. Section Abstract Doc Link 3481211 Disease Relevance 0.07 Pain Relevance 0.10
The increase in kininogen was proportional to the extent of the surgery since simple exposure of the carotid artery increased kininogen to 5.3 +/- 0.5 micrograms bk eq/ml, and sham carotid cannulation to 8.3 +/- 0.4 micrograms bk eq/ml.
Positive_regulation (increased) of kininogen in carotid artery
12) Confidence 0.37 Published 1987 Journal Agents Actions Suppl. Section Abstract Doc Link 3481211 Disease Relevance 0.07 Pain Relevance 0.13
The marked plasmatic levels increase of thiostatin and the hypoalbuminemia in rats with a portosystemic shunt may be involved in the acute phase changes associated with a systemic inflammatory response [32,33].
Positive_regulation (increase) of thiostatin associated with inflammatory response and hypoalbuminemia
13) Confidence 0.35 Published 2008 Journal Comp Hepatol Section Body Doc Link PMC2262055 Disease Relevance 0.97 Pain Relevance 0.13
Aspartate-aminotransferase (AST) (p = 0.004), alanine-aminotransferase (ALT) (p = 0.0001), ammonia (p = 0.0001) and thiostatin (p = 0.0001) serum levels are higher in PCS-rats compared to control rats.
Positive_regulation (higher) of thiostatin
14) Confidence 0.23 Published 2008 Journal Comp Hepatol Section Body Doc Link PMC2262055 Disease Relevance 0.34 Pain Relevance 0.03
These results suggest that bromelain could deplete the HMW-kininogen in mouse plasma in the same way as in rat plasma.
Positive_regulation (deplete) of HMW-kininogen in plasma
15) Confidence 0.10 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2614639 Disease Relevance 0 Pain Relevance 0.04
Both sialylation and fucosylation increased as a function of cancer on several proteins including Hemopexin, Kininogen-1, Antithrombin-III, and Haptoglobin-related protein, whereas decreased sialylation was detected on plasma protease C1 inhibitor.
Positive_regulation (increased) of Kininogen-1 in plasma associated with cancer
16) Confidence 0.02 Published 2007 Journal J. Proteome Res. Section Abstract Doc Link 17428079 Disease Relevance 1.17 Pain Relevance 0.43
Components of the kallikrein-kininogen-kinin are activated in response to noxious stimuli (chemical, physical or bacterial), which may lead to excessive release of kinins in the synovial joints that may produce inflammatory joint disease.
Positive_regulation (activated) of kallikrein-kininogen-kinin in synovial joints associated with inflammation and arthropathy
17) Confidence 0.00 Published 1991 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 1365470 Disease Relevance 0.50 Pain Relevance 0.29

General Comments

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