INT82370

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.72
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psap) extracellular space (Psap) extracellular region (Psap)
Golgi apparatus (Psap) lipid metabolic process (Psap) lysosome (Psap)
Anatomy Link Frequency
nerve 1
peripheral nerve 1
Psap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 2 95.36 Very High Very High Very High
hypoalgesia 2 92.64 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 12 99.52 Very High Very High Very High
Injury 4 99.02 Very High Very High Very High
Peripheral Neuropathy 2 94.88 High High
Hypoalagesia 2 92.64 High High
Nervous System Injury 4 84.12 Quite High
Hyperglycemia 2 76.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prosaposin gene expression and the efficacy of a prosaposin-derived peptide in preventing structural and functional disorders of peripheral nerve in diabetic rats.
Gene_expression (expression) of Prosaposin gene in peripheral nerve associated with diabetes mellitus
1) Confidence 0.77 Published 1999 Journal J. Neuropathol. Exp. Neurol. Section Title Doc Link 10374753 Disease Relevance 0.65 Pain Relevance 0.08
It is concluded that nerve subject to the metabolic injury of uncontrolled diabetes responds by increasing prosaposin gene expression, and that prosaposin-derived neurotrophic peptides may provide a novel therapeutic approach to treatment of diabetic and other peripheral neuropathies.
Gene_expression (expression) of prosaposin gene in nerve associated with diabetes mellitus, injury and peripheral neuropathy
2) Confidence 0.77 Published 1999 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 10374753 Disease Relevance 1.08 Pain Relevance 0.14

General Comments

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