INT82374

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 13.69
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (SYP)
Anatomy Link Frequency
neuron 4
stroma 1
neuronal 1
sustentacular cells 1
SYP (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 9 99.92 Very High Very High Very High
Inflammation 14 89.84 High High
Bile 5 86.20 High High
pulpitis 1 86.00 High High
Serotonin 1 85.92 High High
imagery 27 83.08 Quite High
abdominal pain 6 81.88 Quite High
headache 11 77.60 Quite High
Angina 1 65.92 Quite High
Potency 3 60.72 Quite High
Disease Link Frequency Relevance Heat
Sarcoma 9 99.92 Very High Very High Very High
Cancer 283 99.78 Very High Very High Very High
Oligodendroglioma 57 99.76 Very High Very High Very High
Granular Cell Tumor 33 98.60 Very High Very High Very High
Lymphatic System Cancer 43 98.44 Very High Very High Very High
Congenital Anomalies 6 98.32 Very High Very High Very High
Small Cell Lung Cancer 2 97.52 Very High Very High Very High
Ganglion Cysts 50 96.72 Very High Very High Very High
Pheochromocytoma 2 96.00 Very High Very High Very High
Paraganglioma 40 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies performed in two cases showed positivity of the tumor cells for keratin, Leu 7, and synaptophysin, and focal chromogranin positivity in one.
synaptophysin Binding (keratin) of associated with cancer
1) Confidence 0.36 Published 1999 Journal Hum. Pathol. Section Abstract Doc Link 10374770 Disease Relevance 1.00 Pain Relevance 0.07
In the described case, the patient was positive for synaptophysin and neuron specific antigen, focally positive for chromogranin, partially positive in stroma for S-100, and negative for cytokeratin.
synaptophysin Binding (negative) of in stroma
2) Confidence 0.36 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2887868 Disease Relevance 1.81 Pain Relevance 0.21
The tumor cells showed positive reactivity for synaptophysin, somatostatin, and CD56.
synaptophysin Binding (reactivity) of associated with cancer and somatostatin
3) Confidence 0.36 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2874790 Disease Relevance 1.23 Pain Relevance 0.12
Synaptophysin, Microtubule-Associated Protein 2 and neuronal counts
Synaptophysin Binding (counts) of in neuronal
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.53 Pain Relevance 0.03
Staining for both synaptophysin and neurofilament protein was noted only in association with the neurons and their processes.
synaptophysin Binding (Staining) of in neurons
5) Confidence 0.36 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2642879 Disease Relevance 0.29 Pain Relevance 0
Immunohistochemistry demonstrated many different patterns; nevertheless, most lesions were positive for Grimelius, synaptophysin, neuron-specific enolase and chromogranin but negative for Fontana-Masson.
synaptophysin Binding (positive) of in neuron
6) Confidence 0.36 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2386474 Disease Relevance 1.10 Pain Relevance 0.04
Immunohistochemistry showed strong and diffuse positivity for synaptophysin, chromogranin (Figure 1c), cytokeratin (Figure 1d) Bcl-2 protein and neuron-specific enolase (NSE) but negativity for S100, desmin and epithelial membrane antigen (EMA).
synaptophysin Binding (positivity) of in neuron
7) Confidence 0.36 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 1.21 Pain Relevance 0
Positivity with neuron specific enolase, chromogranin and synaptophysin was not seen and S-100 staining was seen in tumor cells and not in sustentacular cells as noted in pheochromocytoma

Course

synaptophysin Binding (Positivity) of in sustentacular cells associated with cancer and pheochromocytoma
8) Confidence 0.36 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1828733 Disease Relevance 0.95 Pain Relevance 0
A population of neuroendocrine cells positively reacting to neuron-specific enolase, synaptophysin, chromogranin A, and stained with paraldehyde-fuchsin, was detected in the subodontoblastic layer of the pulp.
synaptophysin Binding (reacting) of in neuron
9) Confidence 0.36 Published 2007 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 18457032 Disease Relevance 0.07 Pain Relevance 0.09
Histologically, the tumor was composed of two areas, a main area of large neoplastic cells with pleomorphic atypical nuclei and abundant cytoplasm, which by immunohistochemistry was reactive for glial fibrillary acidic protein, mixed with several foci of poorly differentiated tumoral cells with elongated nuclei and scant cytoplasm, negative for GFAP, but robustly immunoreactive for synaptophysin and phosphoneurofilaments.
synaptophysin Binding (immunoreactive) of associated with cancer
10) Confidence 0.36 Published 2006 Journal Acta Neuropathol. Section Abstract Doc Link 16557392 Disease Relevance 1.13 Pain Relevance 0.08
In difficult cases, immunostains for cytokeratin, CD45, synaptophysin, and chromogranin help make the correct diagnosis.
synaptophysin Binding (cytokeratin) of
11) Confidence 0.36 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2905343 Disease Relevance 2.32 Pain Relevance 0.15
In addition, neurofilament protein and chromogranin were strongly reactive in approximately 15% of the tumor cell population, whereas reactivity for synaptophysin was uniform throughout the tumor.
synaptophysin Binding (reactivity) of associated with cancer
12) Confidence 0.35 Published 2004 Journal Acta Neuropathol. Section Abstract Doc Link 15173951 Disease Relevance 1.25 Pain Relevance 0.06
The majority of oligodendroglioma cells were negative for synaptophysin (c) and Neu-N (e), although both these stains highlighted entrapped native elements, consistent with an infiltrative growth pattern.
synaptophysin Binding (negative) of associated with oligodendroglioma
13) Confidence 0.08 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892612 Disease Relevance 0.78 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox