INT82381

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.97
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

sulfur compound metabolic process (Sult4a1) cytoplasm (Sult4a1)
Anatomy Link Frequency
midline 2
spinal 1
hypothalamus 1
Sult4a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 1 99.20 Very High Very High Very High
midbrain 42 99.12 Very High Very High Very High
Spinal cord 3 97.00 Very High Very High Very High
Hyperalgesia 2 95.40 Very High Very High Very High
Pain 3 92.44 High High
tail-flick 1 91.00 High High
antagonist 1 88.84 High High
gABA 2 87.88 High High
intrathecal 1 86.24 High High
Glutamate 4 85.72 High High
Disease Link Frequency Relevance Heat
Obesity 21 96.60 Very High Very High Very High
Hyperalgesia 2 95.40 Very High Very High Very High
Pain 3 92.44 High High
Fever 3 91.20 High High
Bordatella Infection 1 74.24 Quite High
Nociception 2 68.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present experiments were carried out to examine whether and where the proposed midbrain region contains cell bodies that tonically inhibit the NST, and if so, whether they receive any influence from the hypothalamus.
Negative_regulation (inhibit) of NST in hypothalamus associated with midbrain
1) Confidence 0.59 Published 1999 Journal Brain Res. Section Abstract Doc Link 10375700 Disease Relevance 0.29 Pain Relevance 0.33
These results suggest that neurons that tonically inhibit the NST are located in the area close to the midline adjacent to the RRF and rs, and that the integrity of the neurons to tonically inhibit the NST is not affected by disconnecting the hypothalamus from the midbrain.
Negative_regulation (inhibit) of NST in midline associated with midbrain
2) Confidence 0.59 Published 1999 Journal Brain Res. Section Abstract Doc Link 10375700 Disease Relevance 0.55 Pain Relevance 0.56
These results suggest that neurons that tonically inhibit the NST are located in the area close to the midline adjacent to the RRF and rs, and that the integrity of the neurons to tonically inhibit the NST is not affected by disconnecting the hypothalamus from the midbrain.
Negative_regulation (inhibit) of NST in midline associated with midbrain
3) Confidence 0.59 Published 1999 Journal Brain Res. Section Abstract Doc Link 10375700 Disease Relevance 0.51 Pain Relevance 0.53
In addition, they support a role of NST as an endogenous inhibitor of glycinergic and GABAergic neurotransmission in the sensory part of the spinal cord and as a mediator of spinal hyperalgesia.
Negative_regulation (inhibitor) of NST in spinal associated with hyperalgesia, gabaergic and spinal cord
4) Confidence 0.42 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10864950 Disease Relevance 0.62 Pain Relevance 0.97

General Comments

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