INT82398

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Context Info
Confidence 0.35
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.82
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DMB) plasma membrane (HLA-DMB)
HLA-DMB (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 6 99.40 Very High Very High Very High
Multiple sclerosis 96 95.32 Very High Very High Very High
rheumatoid arthritis 103 95.04 Very High Very High Very High
spinal inflammation 53 94.28 High High
Arthritis 16 90.24 High High
tetrodotoxin 1 84.00 Quite High
Central nervous system 2 78.80 Quite High
Inflammation 10 67.60 Quite High
Crohn's disease 26 16.60 Low Low
Infliximab 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 68 99.76 Very High Very High Very High
Psoriasis 6 99.40 Very High Very High Very High
Rheumatic Diseases 5 99.28 Very High Very High Very High
Disease 296 95.44 Very High Very High Very High
Demyelinating Disease 100 95.32 Very High Very High Very High
Rheumatoid Arthritis 117 95.04 Very High Very High Very High
Low Back Pain 53 94.28 High High
Autoimmune Disease 106 93.28 High High
Seronegative Spondarthritis 2 90.64 High High
Genetic Predisposition To Disease 4 86.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While mutations in this gene have been previously associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and Grave’s Disease [28]–[30], the inverse allelic relationship has not been previously recognized. rs1265048 falls near CDSN and PSORS1C1 both of which have previously been associated with susceptibility to psoriasis [31],[32]. rs151719 falls in HLA-DMB, an MHC class II molecule that has been previously associated with T1D [33].
HLA-DMB Binding (associated) of associated with psoriasis, spinal inflammation, diabetes mellitus and disease
1) Confidence 0.35 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2791168 Disease Relevance 1.30 Pain Relevance 0.20
Those include polymorphisms in HLA-B associated transcript 3 (BAT3), E74-like factor 1 (ELF1), HLA-DMB, VARS2, BTNL2, TRIM40, ZSCAN23 and CDSN.
HLA-DMB Binding (associated) of
2) Confidence 0.35 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2791168 Disease Relevance 1.71 Pain Relevance 0.91
HLA-DMA and HLA-DMB genotyping in patients with rheumatic diseases.
HLA-DMB Binding (genotyping) of associated with rheumatic diseases
3) Confidence 0.07 Published 1999 Journal Kaohsiung J. Med. Sci. Section Title Doc Link 10375868 Disease Relevance 0.81 Pain Relevance 0.46
Deletion mutagenesis showed that CB-DMB inhibited NCX activity mainly at level of the f-loop but not through the interaction with Gly833 located at the level of the alpha(2) repeat.
CB-DMB Binding (interaction) of
4) Confidence 0.01 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19602550 Disease Relevance 0 Pain Relevance 0.08

General Comments

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