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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.18
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
eye 1
cortex 1

Pain Term Frequency Confidence Heat
Delta opioid receptors 9 96.64 Very High Very High Very High
agonist 2 95.04 Very High Very High Very High
cytokine 63 91.76 High High
cINOD 8 90.32 High High
Morphine 78 87.80 High High
Inflammation 10 86.28 High High
antagonist 2 74.00 Quite High
depression 11 71.60 Quite High
chemokine 11 68.16 Quite High
Enkephalin 1 64.84 Quite High
Disease Term Frequency Confidence Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 100.00 Very High Very High Very High
Death 3 99.46 Very High Very High Very High
Apoptosis 12 94.88 High High
Colon Cancer 9 94.16 High High
INFLAMMATION 16 86.28 High High
Bordatella Infection 1 75.08 Quite High
Depression 11 71.60 Quite High
Cancer 1 68.12 Quite High
Toxicity 1 65.48 Quite High
Stress 4 64.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional studies showed that DADLE stimulated an increase in cfos mRNA; this was reduced by the inhibitor of MAPK/ERK kinase (MEK), PD98059.
Negative_regulation (inhibitor) of MAPK
1) Confidence 0.57 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10376935 Disease Relevance 0.08 Pain Relevance 0.53
The SB203580, a p38 MAP kinase inhibitor, reduced indomethacin-induced cell death by 43%, while PD098059, a MAPK/ERK kinase (MEK)1 inhibitor, did not affect cell death. p38 MAP kinase and caspase-3 activation were not significantly interlinked in indomethacin-induced apoptosis.
Negative_regulation (inhibitor) of MAPK associated with apoptosis and death
2) Confidence 0.57 Published 2001 Journal Int J Colorectal Dis Section Abstract Doc Link 11459290 Disease Relevance 0.97 Pain Relevance 0.42
For example, protein synthesis inhibition in entorhinal cortex affects consolidation but not reconsolidation of object memory (Lima et al., 2009), while in the ventromedial prefrontal cortex, protein synthesis inhibition, as well as NMDA blockade or MAPK/ERK inhibition were shown to block both consolidation and reconsolidation of object memory (Akirav and Maroun, 2006; Maroun and Akirav, 2009).
Negative_regulation (inhibition) of MAPK in cortex
3) Confidence 0.57 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.13 Pain Relevance 0.04
We also found that PD98059, a MEK (MAPK/ERK kinase) inhibitor, attenuated the eupatilin-induced HO-1 expression and nuclear translocation of transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2).
Negative_regulation (inhibitor) of MAPK
4) Confidence 0.42 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18440740 Disease Relevance 0.14 Pain Relevance 0.07
In particular, the analogue displaying two nitro-oxy functions fully mimicked the known inhibitory properties of celecoxib, including inhibition of COX-2, as well as of ERK/MAPK and beta-catenin signalling pathways.
Negative_regulation (inhibition) of MAPK
5) Confidence 0.41 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19682443 Disease Relevance 0.53 Pain Relevance 0.09
LMB at a low concentration is a potent and specific inhibitor of many proteins including the HIV-1 Rev protein, MAPK/ERK, and the nuclear export protein CRM1 [50], [51].
Negative_regulation (inhibitor) of MAPK associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.10 Pain Relevance 0.46
Inhibition of the EGFR/Ras1/MAPK pathway enhances cell killing activity and, like endoAA66W 4.1, causes an eye ablation phenotype [35].
Negative_regulation (Inhibition) of MAPK in eye
7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2831065 Disease Relevance 0.23 Pain Relevance 0
Pretreatment of hippocampal slices with RAS, RAF, MEK, ERK or p38-MAPK inhibitors for 60 min did not significantly change the transcription of c-Fos or Egr-1.
Negative_regulation (inhibitors) of MAPK
8) Confidence 0.41 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0

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