INT82410

Context Info Confidence 0.57 First Reported 1999 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 2.18 Pain Relevance 1.61

Anatomy Mention Frequency eye 1 cortex 1

Pain Term Frequency Confidence Heat Delta opioid receptors 9 96.64 agonist 2 95.04 cytokine 63 91.76 cINOD 8 90.32 Morphine 78 87.80 Inflammation 10 86.28 antagonist 2 74.00 depression 11 71.60 chemokine 11 68.16 Enkephalin 1 64.84

Disease Term Frequency Confidence Heat Acquired Immune Deficiency Syndrome Or Hiv Infection 32 100.00 Death 3 99.46 Apoptosis 12 94.88 Colon Cancer 9 94.16 INFLAMMATION 16 86.28 Bordatella Infection 1 75.08 Depression 11 71.60 Cancer 1 68.12 Toxicity 1 65.48 Stress 4 64.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Additional studies showed that DADLE stimulated an increase in cfos mRNA; this was reduced by the inhibitor of MAPK/ERK kinase (MEK), PD98059.

Negative_regulation (inhibitor) of MAPK

1) Confidence 0.57 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10376935 Disease Relevance 0.08 Pain Relevance 0.53

The SB203580, a p38 MAP kinase inhibitor, reduced indomethacin-induced cell death by 43%, while PD098059, a MAPK/ERK kinase (MEK)1 inhibitor, did not affect cell death. p38 MAP kinase and caspase-3 activation were not significantly interlinked in indomethacin-induced apoptosis.

Negative_regulation (inhibitor) of MAPK associated with apoptosis and death

2) Confidence 0.57 Published 2001 Journal Int J Colorectal Dis Section Abstract Doc Link 11459290 Disease Relevance 0.97 Pain Relevance 0.42

For example, protein synthesis inhibition in entorhinal cortex affects consolidation but not reconsolidation of object memory (Lima et al., 2009), while in the ventromedial prefrontal cortex, protein synthesis inhibition, as well as NMDA blockade or MAPK/ERK inhibition were shown to block both consolidation and reconsolidation of object memory (Akirav and Maroun, 2006; Maroun and Akirav, 2009).

Negative_regulation (inhibition) of MAPK in cortex

3) Confidence 0.57 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.13 Pain Relevance 0.04

We also found that PD98059, a MEK (MAPK/ERK kinase) inhibitor, attenuated the eupatilin-induced HO-1 expression and nuclear translocation of transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2).

Negative_regulation (inhibitor) of MAPK

4) Confidence 0.42 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18440740 Disease Relevance 0.14 Pain Relevance 0.07

In particular, the analogue displaying two nitro-oxy functions fully mimicked the known inhibitory properties of celecoxib, including inhibition of COX-2, as well as of ERK/MAPK and beta-catenin signalling pathways.

Negative_regulation (inhibition) of MAPK

5) Confidence 0.41 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19682443 Disease Relevance 0.53 Pain Relevance 0.09

LMB at a low concentration is a potent and specific inhibitor of many proteins including the HIV-1 Rev protein, MAPK/ERK, and the nuclear export protein CRM1 [50], [51].

Negative_regulation (inhibitor) of MAPK associated with acquired immune deficiency syndrome or hiv infection

6) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.10 Pain Relevance 0.46

Inhibition of the EGFR/Ras1/MAPK pathway enhances cell killing activity and, like endoAA66W 4.1, causes an eye ablation phenotype [35].

Negative_regulation (Inhibition) of MAPK in eye

7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2831065 Disease Relevance 0.23 Pain Relevance 0

Pretreatment of hippocampal slices with RAS, RAF, MEK, ERK or p38-MAPK inhibitors for 60 min did not significantly change the transcription of c-Fos or Egr-1.

Negative_regulation (inhibitors) of MAPK

8) Confidence 0.41 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0

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