INT8243

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2011
Negated 11
Speculated 12
Reported most in Abstract
Documents 451
Total Number 467
Disease Relevance 358.24
Pain Relevance 119.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 30
lung 15
brain 11
monocyte 10
macrophage 10
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 7389 100.00 Very High Very High Very High
cytokine 6388 100.00 Very High Very High Very High
Arthritis 1166 100.00 Very High Very High Very High
chemokine 991 100.00 Very High Very High Very High
ischemia 433 100.00 Very High Very High Very High
Pain 429 100.00 Very High Very High Very High
Inflammatory mediators 345 100.00 Very High Very High Very High
Inflammatory marker 182 100.00 Very High Very High Very High
medulla 77 100.00 Very High Very High Very High
Nerve growth factor 34 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 8633 100.00 Very High Very High Very High
Disease 4596 100.00 Very High Very High Very High
Cancer 2522 100.00 Very High Very High Very High
Infection 2154 100.00 Very High Very High Very High
Hypoxia 2084 100.00 Very High Very High Very High
Arthritis 1129 100.00 Very High Very High Very High
Necrosis 498 100.00 Very High Very High Very High
Pressure And Volume Under Development 468 100.00 Very High Very High Very High
Cv Unclassified Under Development 376 100.00 Very High Very High Very High
Osteoporosis 240 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing the dose of pristane did not substantially increase the peritoneal levels of IL-6 established at 20 weeks after pristane treatment.
Neg (not) Positive_regulation (increase) of IL-6
1) Confidence 0.70 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.46 Pain Relevance 0.18
Serum levels of IL-6 were also elevated in pristane-primed mice but were substantially lower than those found in the peritoneal cavity.
Positive_regulation (elevated) of IL-6 in peritoneal cavity
2) Confidence 0.70 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.54 Pain Relevance 0.22
Elevation of interleukin-6 in response to a chronic inflammatory stimulus in mice: inhibition by indomethacin.
Positive_regulation (Elevation) of interleukin-6 associated with inflammation and inflammatory stimuli
3) Confidence 0.70 Published 1992 Journal Blood Section Title Doc Link 1611085 Disease Relevance 0.40 Pain Relevance 0.19
Characterized by an increase in edema and IL-6, HD provoked a cutaneous inflammatory response in both models beginning at 6 h post-exposure and continuing to 24 h.
Positive_regulation (increase) of IL-6 associated with pressure and volume under development and inflammatory response
4) Confidence 0.70 Published 2000 Journal J Appl Toxicol Section Abstract Doc Link 11428647 Disease Relevance 1.10 Pain Relevance 0.53
Constriction nerve injury, widely used to study neuropathic pain, was shown here to induce interleukin-6 (IL-6) mRNA in a subset of rat primary sensory neurons.
Positive_regulation (induce) of IL-6 in primary sensory neurons associated with nervous system injury and neuropathic pain
5) Confidence 0.70 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10383613 Disease Relevance 0.70 Pain Relevance 0.57
Constriction nerve injury, widely used to study neuropathic pain, was shown here to induce interleukin-6 (IL-6) mRNA in a subset of rat primary sensory neurons.
Positive_regulation (induce) of interleukin-6 in primary sensory neurons associated with nervous system injury and neuropathic pain
6) Confidence 0.70 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10383613 Disease Relevance 0.70 Pain Relevance 0.57
An important finding from our study was that exposure to hypoxia was associated with a marked and early rise in IL-6 mRNA levels, which led to a more prolonged increase in IL-6 protein, lasting up to 7 days but followed by a return to basal levels by day 14.
Positive_regulation (increase) of IL-6 protein associated with hypoxia
7) Confidence 0.70 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.37 Pain Relevance 0.22
Lung IL-6 protein levels were also increased at 24 hours but remained elevated on day 7 then returned to basal values by day 14 (Figure 2b).
Positive_regulation (increased) of IL-6 protein in Lung
8) Confidence 0.70 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.86 Pain Relevance 0
Moreover, circulating IL-6 seems to be increased in most forms of human PH [4,14-16] and several experimental studies recently reported an active role of IL-6 on pulmonary vascular remodeling and hypoxic PH in mice [24].
Positive_regulation (increased) of IL-6 associated with primary pulmonary hypertension and hypoxia
9) Confidence 0.70 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.62 Pain Relevance 0.32
This hyperalgesia is accompanied by a sustained upregulation of interleukin-1beta (IL-1beta) and an early upregulation of interleukin-6 (IL-6) which is restored to normal levels after five days of infection.
Positive_regulation (upregulation) of interleukin-6 associated with hyperalgesia and infection
10) Confidence 0.70 Published 2006 Journal Exp. Parasitol. Section Abstract Doc Link 16516198 Disease Relevance 1.43 Pain Relevance 0.72
This hyperalgesia is accompanied by a sustained upregulation of interleukin-1beta (IL-1beta) and an early upregulation of interleukin-6 (IL-6) which is restored to normal levels after five days of infection.
Positive_regulation (upregulation) of IL-6 associated with hyperalgesia and infection
11) Confidence 0.70 Published 2006 Journal Exp. Parasitol. Section Abstract Doc Link 16516198 Disease Relevance 1.43 Pain Relevance 0.72
In conclusion, this study shows that, during early infection, the low dose of L. major causes hyperalgesia accompanied by an upregulation of IL-1beta and IL-6 and that these effects are reversed within the first two weeks of infection.
Positive_regulation (upregulation) of IL-6 associated with hyperalgesia and infection
12) Confidence 0.70 Published 2006 Journal Exp. Parasitol. Section Abstract Doc Link 16516198 Disease Relevance 1.44 Pain Relevance 0.68
RT-PCR experiments demonstrated that U50,488 treatment significantly reduced the LPS-mediated increase in IL-6 mRNA and that this effect was also blocked by nor-BNI.
Positive_regulation (increase) of IL-6 mRNA
13) Confidence 0.70 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16644488 Disease Relevance 0.20 Pain Relevance 0.75
Stress effects on the hypopituitary axis can also lead to local induction of IL-6 in brain and secondary release into blood, a potential additional source of IL-6 in both brain and plasma[3] (and references therein).
Positive_regulation (induction) of IL-6 in brain associated with stress
14) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.33 Pain Relevance 0.07
Aging increases IL-6 in plasma and brain
Positive_regulation (increases) of IL-6 in brain associated with aging
15) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.41 Pain Relevance 0.15
Factors responsible for peripheral IL-6 induction in aging humans include diet, hormone status, activity, and genetics[2], [3], [5], [46], [47], and while mechanisms which increase IL-6 in the nervous system are less well understood, direct entry of plasma IL-6 into brain has been shown[12].
Positive_regulation (increase) of IL-6 in plasma associated with aging
16) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.28 Pain Relevance 0.04
Factors responsible for peripheral IL-6 induction in aging humans include diet, hormone status, activity, and genetics[2], [3], [5], [46], [47], and while mechanisms which increase IL-6 in the nervous system are less well understood, direct entry of plasma IL-6 into brain has been shown[12].
Positive_regulation (induction) of IL-6 in plasma associated with aging
17) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.28 Pain Relevance 0.04
These findings show that, despite what might be predicted from studies conducted in vitro, chronic exposure to elevated plasma IL-6 concentrations in itself does not predispose the mouse to enhanced responsiveness to vasoconstrictors in vivo.
Positive_regulation (elevated) of IL-6 in plasma
18) Confidence 0.68 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17557918 Disease Relevance 0.07 Pain Relevance 0.13
In addition, IL-6 was increased in the sera and in the sacroiliac joints of hTNFtg animals.
Positive_regulation (increased) of IL-6 in sacroiliac joints
19) Confidence 0.67 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 20498200 Disease Relevance 0.36 Pain Relevance 0
First an increase in met-enkephalin plasma levels occurred (8.9+/-2.9 to 135+/-18 pg/ml; P<0.005), and then an increase in plasma IL-6 levels (2.1+/-1.5 to 237+/-50 pg/ml; P<0.001), suggesting that, as in mice, met-enkephalin induces IL-6 production.
Positive_regulation (increase) of IL-6 in plasma associated with enkephalin
20) Confidence 0.66 Published 1998 Journal Int. J. Cardiol. Section Abstract Doc Link 9687093 Disease Relevance 0 Pain Relevance 0.88

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