INT82434

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2011
Negated 6
Speculated 7
Reported most in Body
Documents 117
Total Number 123
Disease Relevance 95.45
Pain Relevance 20.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
plasma 9
fat 9
chondrocytes 6
peritoneal fluid 4
adipocytes 4
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 318 99.96 Very High Very High Very High
Inflammatory response 34 99.92 Very High Very High Very High
spinal inflammation 16 99.92 Very High Very High Very High
Dismenorea 24 99.84 Very High Very High Very High
Pain threshold 7 99.84 Very High Very High Very High
Osteoarthritis 881 99.64 Very High Very High Very High
Pain 142 99.56 Very High Very High Very High
endometriosis 67 99.52 Very High Very High Very High
Angina 53 99.48 Very High Very High Very High
Endep 19 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 3716 100.00 Very High Very High Very High
Pulmonary Disease 298 100.00 Very High Very High Very High
Body Weight 222 100.00 Very High Very High Very High
Polio 6 100.00 Very High Very High Very High
Aging 201 99.92 Very High Very High Very High
Low Back Pain 32 99.92 Very High Very High Very High
Weight Loss 476 99.90 Very High Very High Very High
Apnoea 357 99.84 Very High Very High Very High
Pain 136 99.84 Very High Very High Very High
Reprotox - General 1 69 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma leptin concentrations are increased in women with premenstrual syndrome.
Positive_regulation (increased) of leptin in Plasma associated with dismenorea
1) Confidence 0.70 Published 2000 Journal Hum. Reprod. Section Title Doc Link 11056127 Disease Relevance 0.74 Pain Relevance 0.59
We postulated that circulating leptin concentrations are increased in premenstrual syndrome (PMS), and that this may be associated with the psychological symptoms of the disease.
Positive_regulation (increased) of leptin associated with dismenorea and disease
2) Confidence 0.70 Published 2000 Journal Hum. Reprod. Section Abstract Doc Link 11056127 Disease Relevance 0.66 Pain Relevance 0.48
Leptin levels increase exponentially with increasing body weight [11,22,23] and previous studies [22,24,25] have reported a significant correlation between measures of body fat and circulating concentrations of leptin in adults.
Positive_regulation (increase) of Leptin in fat associated with body weight
3) Confidence 0.70 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 1.01 Pain Relevance 0.11
Sixty percent of patients presented elevated basal leptin levels.
Positive_regulation (elevated) of leptin
4) Confidence 0.70 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 1.38 Pain Relevance 0.09
In summary, taking all these observations into account our findings suggest that the increased leptin levels described so far in patients with OSA is mostly associated with obesity and not with the disease itself or its severity; accordingly short and long term treatment with CPAP has a small effect on leptin plasma levels and Auto-CPAP therapy compliance is not related with the leptin values decrease.
Positive_regulation (increased) of leptin in plasma associated with apnoea, obesity and disease
5) Confidence 0.70 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 0.47 Pain Relevance 0
Further randomized and controlled studies will be required to determine the pathophysiological meaning of the increased leptin levels and the central role between adipocyte function and atherosclerosis.
Positive_regulation (increased) of leptin in adipocyte associated with atherosclerosis
6) Confidence 0.70 Published 2006 Journal Angiology Section Abstract Doc Link 16703186 Disease Relevance 0.63 Pain Relevance 0.36
Interestingly, leptin has been found to be elevated in several hypertensive states of pregnancy as well (Anato et al 2000; Vitoratos et al 2001).
Positive_regulation (elevated) of leptin associated with hypertension
7) Confidence 0.69 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 1.11 Pain Relevance 0
For instance, Vitoratos et al (2001) reported increased leptin levels in pre-eclamptics compared with normotensive pregnant women of the same gestational age.
Positive_regulation (increased) of leptin
8) Confidence 0.69 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 0.99 Pain Relevance 0
Circulating leptin levels were increased on day one after total abdominal hysterectomy.
Positive_regulation (increased) of leptin
9) Confidence 0.68 Published 2001 Journal Endocr. J. Section Abstract Doc Link 11603576 Disease Relevance 0.51 Pain Relevance 0.07
Endometriosis may be associated with increased levels of leptin in peritoneal fluid.
Positive_regulation (increased) of leptin in peritoneal fluid associated with endometriosis
10) Confidence 0.67 Published 2008 Journal Gynecol. Endocrinol. Section Abstract Doc Link 18958774 Disease Relevance 0.87 Pain Relevance 0.30
It may suggest that increased leptin levels in the peritoneal fluid may play a role in pathogenesis of infertility.
Positive_regulation (increased) of leptin in peritoneal fluid associated with reprotox - general 3
11) Confidence 0.67 Published 2008 Journal Gynecol. Endocrinol. Section Abstract Doc Link 18958774 Disease Relevance 1.04 Pain Relevance 0.37
Since human CRP correlates with increased plasma leptin and adiposity, the results "suggest a potential mechanism to leptin resistance, by which circulating CRP binds to leptin and attenuates its physiological functions [16].
Positive_regulation (increased) of leptin in plasma
12) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.42 Pain Relevance 0.07
The plasma concentrations of leptin are markedly increased in human obesity and positively correlated to body fat mass [26].
Positive_regulation (increased) of leptin in plasma associated with metabolic syndrome
13) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.82 Pain Relevance 0.09
induction of leptin may play a significant role in anorexia and
Positive_regulation (induction) of leptin associated with anorexia
14) Confidence 0.66 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 1.96 Pain Relevance 0.47
as surgical cholecystectomy have been shown to increase leptin
Positive_regulation (increase) of leptin
15) Confidence 0.66 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 1.90 Pain Relevance 0.48
As a defect in leptin action on body weight homeostasis has been reported for obese individuals despite high serum leptin concentrations, the current study was undertaken to determine whether chondrocytes from obese OA patients that are exposed to elevated leptin levels, exhibit an altered response to leptin.
Positive_regulation (elevated) of leptin in chondrocytes associated with body weight, obesity and osteoarthritis
16) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.42 Pain Relevance 0.13
Chondrocytes from obese patients may already be so strongly exposed to elevated leptin levels within the joint that they are refractory to further stimulation.
Positive_regulation (elevated) of leptin in joint associated with obesity
17) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.96 Pain Relevance 0.06
CONCLUSIONS: Higher levels of leptin were observed in peritoneal fluid of patients with endometriosis compared to those without the disease.
Positive_regulation (levels) of leptin in peritoneal fluid
18) Confidence 0.64 Published 2006 Journal Hum. Reprod. Section Body Doc Link 16269446 Disease Relevance 0.11 Pain Relevance 0
Both cyproheptadine and flunarizine (but not amitriptyline and propranolol) caused an increase in leptin levels (P < 0.05).
Positive_regulation (increase) of leptin associated with endep
19) Confidence 0.63 Published 2009 Journal Pediatr. Neurol. Section Abstract Doc Link 19748048 Disease Relevance 0.53 Pain Relevance 0.86
Increased serum leptin concentrations in patients with chronic stable angina pectoris and ST-elevated myocardial infarction.
Positive_regulation (Increased) of serum leptin associated with stable angina pectoris, angina and myocardial infarction
20) Confidence 0.61 Published 2006 Journal Angiology Section Title Doc Link 16703186 Disease Relevance 1.14 Pain Relevance 0.44

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