INT82441

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Context Info
Confidence 0.23
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.07
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp4f18) endoplasmic reticulum (Cyp4f18)
Cyp4f18 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 13 99.10 Very High Very High Very High
aspirin 5 95.86 Very High Very High Very High
opiate 1 95.76 Very High Very High Very High
Opioid 1 95.20 Very High Very High Very High
Codeine 2 93.52 High High
Oxycodone 1 91.76 High High
Inflammation 18 82.40 Quite High
Analgesic 5 75.00 Quite High
Pain 6 70.52 Quite High
Calcium channel 2 68.72 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 5 98.76 Very High Very High Very High
Stress 13 95.12 Very High Very High Very High
INFLAMMATION 17 82.40 Quite High
Toxicity 8 72.56 Quite High
Pain 6 70.52 Quite High
Cv General 3 Under Development 1 63.04 Quite High
Cardiovascular Disease 3 61.68 Quite High
Hypertension 4 57.76 Quite High
Starvation 8 37.36 Quite Low
Hypoxia 2 7.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This article will address the safety and efficacy of acetaminophen, aspirin, and ibuprofen independently and in combination with currently available prescription dosage forms with a focus on pharmacology, pharmacotherapeutics, pharmacodynamics, and pharmacokinetics, including drug interactions at the CYP450 system.
CYP450 Binding (interactions) of associated with aspirin and paracetamol
1) Confidence 0.23 Published 2001 Journal Am J Ther Section Abstract Doc Link 11704782 Disease Relevance 0.24 Pain Relevance 1.24
The hepatotoxicity of acetaminophen is conventionally ascribed to metabolism by CYP450 to N-acetyl-p-benzoquinone imine and covalent binding to proteins.
CYP450 Binding (binding) of associated with paracetamol and hepatotoxicity
2) Confidence 0.02 Published 1999 Journal Toxicol. Lett. Section Abstract Doc Link 10378453 Disease Relevance 0.43 Pain Relevance 0.54
Both CYP4F3B and CYP4F2 P450 can metabolize arachidonic acid to 20-HETE while CYP4F3A has little activity towards arachidonic acid.
CYP4F3B Binding (metabolize) of
3) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.22 Pain Relevance 0.11
We demonstrated that the formation of these metabolites was CYP450 dependent and unrelated to FMO activity.
CYP450 Binding (formation) of
4) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.18 Pain Relevance 0.10

General Comments

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