INT82444

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.36
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cell 10
Cd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 16 99.80 Very High Very High Very High
Multiple sclerosis 14 99.72 Very High Very High Very High
antagonist 22 99.06 Very High Very High Very High
qutenza 12 98.52 Very High Very High Very High
Inflammatory response 12 92.36 High High
Inflammatory marker 4 90.20 High High
cytokine 37 86.84 High High
Inflammation 37 86.48 High High
agonist 64 77.36 Quite High
pulpitis 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 57 99.72 Very High Very High Very High
Bacterial Infection 1 98.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 54 96.92 Very High Very High Very High
INFLAMMATION 51 92.00 High High
Autoimmune Disease 22 90.56 High High
Chronic Obstructive Pulmonary Disease 316 90.40 High High
Immunization 4 83.76 Quite High
Pulpitis 1 75.00 Quite High
Adhesions 6 64.48 Quite High
Inflammatory Bowel Disease 7 58.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The median CD4 count among ?
Positive_regulation (median) of Gene_expression (count) of CD4
1) Confidence 0.47 Published 2010 Journal AIDS Res Ther Section Abstract Doc Link PMC3022663 Disease Relevance 0.69 Pain Relevance 0
Concomitant administration of SP with the non-peptide Neurokinin-1 receptor (NK1R) antagonist SR140333 completely inhibited the SP-mediated augmentation of Con A-induced PBL proliferation and IL-2 production as well as of CD4+ CD25+ and CD4+ RT1B+ T cell numbers in normal and capsaicin-treated rats.
Positive_regulation (augmentation) of Gene_expression (production) of CD4 in T cell associated with qutenza, antagonist and substance p
2) Confidence 0.46 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10378865 Disease Relevance 0 Pain Relevance 0.86
Concomitant administration of SP with the non-peptide Neurokinin-1 receptor (NK1R) antagonist SR140333 completely inhibited the SP-mediated augmentation of Con A-induced PBL proliferation and IL-2 production as well as of CD4+ CD25+ and CD4+ RT1B+ T cell numbers in normal and capsaicin-treated rats.
Positive_regulation (augmentation) of Gene_expression (production) of CD4 in T cell associated with qutenza, antagonist and substance p
3) Confidence 0.46 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10378865 Disease Relevance 0 Pain Relevance 0.86
Increased CD4+ and CD8+ cell counts and an elevation of CD8+:CD4+ ratio are also observed.
Positive_regulation (Increased) of Gene_expression (counts) of CD4
4) Confidence 0.35 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629967 Disease Relevance 0.57 Pain Relevance 0.13
Increased CD4+ and CD8+ cell counts and an elevation of CD8+:CD4+ ratio are also observed.
Positive_regulation (Increased) of Gene_expression (counts) of CD4
5) Confidence 0.35 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629967 Disease Relevance 0.56 Pain Relevance 0.13
Increased CD4+ and CD8+ cell counts and an elevation of CD8+:CD4+ ratio are also observed.
Positive_regulation (elevation) of Gene_expression (counts) of CD4
6) Confidence 0.35 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629967 Disease Relevance 0.56 Pain Relevance 0.13
Increased CD4+ and CD8+ cell counts and an elevation of CD8+:CD4+ ratio are also observed.
Positive_regulation (elevation) of Gene_expression (counts) of CD4
7) Confidence 0.35 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629967 Disease Relevance 0.56 Pain Relevance 0.13
An increase in CD25 and CD54 expression on CD4+ T lymphocytes was related to the bacterial infection (p < 0.05) and accompanied an increase in IL-2 concentration.
Positive_regulation (increase) of Gene_expression (expression) of CD4 in T lymphocytes associated with bacterial infection
8) Confidence 0.29 Published 2002 Journal J Endod Section Abstract Doc Link 12017181 Disease Relevance 0.32 Pain Relevance 0.19
To this end, we generated MBP-specific CD4+ T cell lines (Ben-Nun et al., 1981).
Positive_regulation (generated) of Gene_expression (generated) of CD4 in T cell
9) Confidence 0.20 Published 2010 Journal Brain Section Body Doc Link PMC2892943 Disease Relevance 0.31 Pain Relevance 0.44
Regarding MS, significant increase in IL-17 gene-expression and elevation of number of IL-17-producing CD4+ and CD8+ T cells in active lesions in comparison to silent lesions, or normal tissue were reported [29,30].
Positive_regulation (increase) of Gene_expression (expression) of CD4 in T cells associated with multiple sclerosis
10) Confidence 0.19 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.79 Pain Relevance 0.26

General Comments

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