INT82446

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.79
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cell 6
Cd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 8 100.00 Very High Very High Very High
antagonist 2 99.58 Very High Very High Very High
qutenza 6 97.92 Very High Very High Very High
cytokine 14 89.12 High High
Inflammation 19 88.72 High High
ischemia 14 70.84 Quite High
Central nervous system 5 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 35 99.84 Very High Very High Very High
Infection 11 98.56 Very High Very High Very High
Frailty 1 93.16 High High
INFLAMMATION 23 88.72 High High
Death 7 76.64 Quite High
Cv General 4 Under Development 3 70.84 Quite High
Viral Meningitis 1 60.24 Quite High
Reperfusion Injury 5 55.04 Quite High
Cv Unclassified Under Development 10 54.28 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 25 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concomitant administration of SP with the non-peptide Neurokinin-1 receptor (NK1R) antagonist SR140333 completely inhibited the SP-mediated augmentation of Con A-induced PBL proliferation and IL-2 production as well as of CD4+ CD25+ and CD4+ RT1B+ T cell numbers in normal and capsaicin-treated rats.
Negative_regulation (inhibited) of Positive_regulation (augmentation) of CD4 in T cell associated with qutenza, antagonist and substance p
1) Confidence 0.39 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10378865 Disease Relevance 0 Pain Relevance 0.86
Vogelgesang et al [7] showed that loss of CD4+ T cell activation in stroke patients contributes to stroke-induced immunosuppression.
Negative_regulation (loss) of Positive_regulation (activation) of CD4 in T cell associated with stroke
2) Confidence 0.14 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 1.79 Pain Relevance 0.22
In the switch arm, patients had a mean decrease of 1.1 log10 copies/mL from baseline and an increase of 116 CD4+ T-cells.
Negative_regulation (decrease) of Positive_regulation (increase) of CD4 in T-cells
3) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504070 Disease Relevance 0 Pain Relevance 0

General Comments

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