INT82450

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Context Info
Confidence 0.55
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 33
Total Number 35
Disease Relevance 19.07
Pain Relevance 8.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
platelet 2
plasma 1
ventricles 1
liver 1
kidney 1
Hmox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 51 99.98 Very High Very High Very High
qutenza 6 99.68 Very High Very High Very High
intrathecal 1 99.62 Very High Very High Very High
aspirin 16 98.98 Very High Very High Very High
rheumatoid arthritis 4 98.80 Very High Very High Very High
Analgesic 1 98.58 Very High Very High Very High
Osteoarthritis 1 98.56 Very High Very High Very High
Calcitonin gene-related peptide 10 98.04 Very High Very High Very High
anesthesia 14 97.68 Very High Very High Very High
Versed 3 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 117 99.86 Very High Very High Very High
Pulmonary Disease 117 99.48 Very High Very High Very High
Cancer 29 99.20 Very High Very High Very High
Sepsis 133 99.00 Very High Very High Very High
Disease 25 98.96 Very High Very High Very High
Toxicity 13 98.84 Very High Very High Very High
Osteoarthritis 1 98.56 Very High Very High Very High
Hypertension 72 98.40 Very High Very High Very High
Hypotension 86 97.92 Very High Very High Very High
Pressure Volume 2 Under Development 12 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extent of HO activity inhibition was measured using a spectrophotometric assay of bilirubin production and blood flow rates to the tumor and a range of normal tissues were assessed using the uptake of the radiolabelled tracer, iodo-antipyrine ((125)I-IAP).
Negative_regulation (inhibition) of HO in blood associated with cancer
1) Confidence 0.55 Published 2003 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 12709573 Disease Relevance 0.63 Pain Relevance 0.11
Mucosal lesions were assessed by prior treatment with a HO-1 inhibitor, zinc protoporphyrin (ZnPP).
Negative_regulation (inhibitor) of HO-1
2) Confidence 0.54 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18617559 Disease Relevance 0.21 Pain Relevance 0.10
Administration of higenamine (bolus, i.p) 1 h prior to I/R-injury significantly decreased the release of cytochrome c, caspase-3 activity, and Bax expression but up-regulated the expression of Bcl-2, HO-1, and HO enzyme activity in the left ventricles, which were inhibited by ZnPP IX, an enzyme inhibitor of HO-1.
Negative_regulation (inhibitor) of HO-1 in ventricles associated with injury
3) Confidence 0.54 Published 2006 Journal Apoptosis Section Abstract Doc Link 16703264 Disease Relevance 0.87 Pain Relevance 0.15
The cardioprotection as well as the synthesis and release of CGRP induced by MLA were completely abolished by pretreatment with zinc protoporphrin IX (ZnPP-9), an inhibitor of HO-1, or by capsaicin (50 mg/kg, s.c.), which selectively depletes transmitters in capsaicin-sensitive sensory nerves.
Negative_regulation (inhibitor) of HO-1 in sensory nerves associated with qutenza and calcitonin gene-related peptide
4) Confidence 0.52 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 11738242 Disease Relevance 0 Pain Relevance 0.69
A part of the toxicity of conventional non-steroidal anti-inflammatory drugs is due to their "topical" effect as well as their inhibition of cyclo-oxygenase-1.
Negative_regulation (inhibition) of cyclo-oxygenase-1 associated with toxicity, inflammation and cinod
5) Confidence 0.48 Published 1999 Journal Ital J Gastroenterol Hepatol Section Abstract Doc Link 10379467 Disease Relevance 0.43 Pain Relevance 0.33
Inhibition of HO activity decreases sodium and fluid reabsorption in the thick ascending limb of the loop of Henle in the rat [19].
Negative_regulation (Inhibition) of HO in ascending limb
6) Confidence 0.47 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.53 Pain Relevance 0.04
In contrast, inhibition of HO activity exacerbated renal damage in a renovascular hypertension animal model [28,29].
Negative_regulation (inhibition) of HO associated with hypertension
7) Confidence 0.47 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.88 Pain Relevance 0
For demonstrating the protective role of HO-1, its enzymatic activity was competitively inhibited by administration of zinc protoporphyrin IX (ZnPPIX), and HO-1 synthesis was blocked with HO-1 siRNA.
Negative_regulation (blocked) of HO-1
8) Confidence 0.42 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404038 Disease Relevance 0.78 Pain Relevance 0.34
HO-1 immunostaining showed an appreciable HO-1 expression in PC groups, which was abolished with HO-1 siRNA administration, but not in ZnPPIX group.
Negative_regulation (abolished) of HO-1
9) Confidence 0.42 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404038 Disease Relevance 0.73 Pain Relevance 0.34
Our results revealed that HO1 may plays an important role in cellular protection against oxidative stress due to mustard gas toxicity in airway wall of SM exposed patients at mRNA level, but translational modifications might cause decrease in the amount of HO1 protein.



Spec (might) Negative_regulation (decrease) of HO1 associated with stress and toxicity
10) Confidence 0.42 Published 2010 Journal Gene Regul Syst Bio Section Abstract Doc Link PMC2956478 Disease Relevance 0.26 Pain Relevance 0
This finding suggests depletion of HO-1 might be a reasonable result for the secondary effect of SM and disturbing between the rate of ROS production and the effect of protective antioxidatiants.



Negative_regulation (depletion) of HO
11) Confidence 0.42 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0 Pain Relevance 0
Male BD9 rats bearing subcutaneous transplants of the P22 carcinosarcoma tumor were treated intraperitoneally (i.p.) with either tin-protoporphyrin IX (SnPP; 45 micromol/kg), a selective inhibitor of HO or copper-protoporphyrin IX (CuPP; 45 micromol/kg), used as a negative control.
Negative_regulation (inhibitor) of HO associated with carcinosarcoma and cancer
12) Confidence 0.41 Published 2003 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 12709573 Disease Relevance 0.56 Pain Relevance 0.10
Chae and colleagues [14] demonstrated that the inhibition of HO-1 with using the HO-1 inhibitor ZnPP or HO-1 siRNA resulted in a striking increase of apoptosis in the CO/TNF-alpha-treated cells.
Negative_regulation (inhibition) of HO associated with apoptosis
13) Confidence 0.39 Published 2008 Journal Ir J Med Sci Section Body Doc Link PMC2777231 Disease Relevance 0.54 Pain Relevance 0
At the same time, HO-1 mRNA, and HO-1 protein in femoral artery and plasma CO dramatically decreased.
Negative_regulation (decreased) of HO in plasma
14) Confidence 0.39 Published 2008 Journal Ir J Med Sci Section Body Doc Link PMC2777231 Disease Relevance 0.73 Pain Relevance 0
Downregulation of HO-1 protein by ZnPP-IX in septic shock was found in the liver, lung, and kidney resulting in a increasing of the end-organ dysfunctions, and meanwhile CO concentration and SOD activity reduced, and MDA contents and pulmonary vascular leakage increased.
Negative_regulation (Downregulation) of HO in kidney associated with sepsis
15) Confidence 0.38 Published 2008 Journal Ir J Med Sci Section Body Doc Link PMC2777231 Disease Relevance 0.71 Pain Relevance 0
In the P22 tumor, SnPP, but not CuPP, caused a complete inhibition of HO activity 15 min post-treatment.
Negative_regulation (inhibition) of HO associated with cancer
16) Confidence 0.36 Published 2003 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 12709573 Disease Relevance 0.72 Pain Relevance 0.15
Concomitant non-steroidal anti-inflammatory drug users were defined as patients who received > or =7 continuous days of any dose of a dual cyclo-oxygenase-1 and cyclo-oxygenase-2 inhibiting non-steroidal anti-inflammatory drug, a selective cyclo-oxygenase-2 inhibitor, or aspirin.
Negative_regulation (inhibitor) of cyclo-oxygenase-1
17) Confidence 0.35 Published 2005 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15740544 Disease Relevance 0.07 Pain Relevance 0
We used ZnPP-IX instead of other metalloporphyrins to inhibit HO activity because ZnPP-IX has been shown to be selective for HO over other microsomal enzymes [13].
Negative_regulation (inhibit) of HO
18) Confidence 0.34 Published 2008 Journal Ir J Med Sci Section Body Doc Link PMC2777231 Disease Relevance 0.65 Pain Relevance 0
Thirty minutes before the test, rats were pretreated with intrathecal injections of the HO inhibitor, zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG) or heme-lysinate, which is a substrate of the HO pathway.
Negative_regulation (inhibitor) of HO associated with intrathecal
19) Confidence 0.32 Published 2009 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 19219308 Disease Relevance 0.26 Pain Relevance 0.33
Recent studies have described a potential genetic basis for the HO-1 downregulation observed in COPD.
Negative_regulation (downregulation) of HO-1 associated with pulmonary disease
20) Confidence 0.28 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 1.28 Pain Relevance 0

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