INT82451

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Context Info
Confidence 0.51
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 13.29
Pain Relevance 5.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
Anatomy Link Frequency
leukocytes 1
endothelial cells 1
Hepa-1c1c7 1
immune system 1
platelet 1
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 79 99.92 Very High Very High Very High
rheumatoid arthritis 71 99.56 Very High Very High Very High
ischemia 7 99.52 Very High Very High Very High
Central nervous system 15 99.28 Very High Very High Very High
Inflammation 142 99.12 Very High Very High Very High
aspirin 11 99.00 Very High Very High Very High
Morphine 24 97.92 Very High Very High Very High
Inflammatory response 49 97.28 Very High Very High Very High
Paracetamol 4 96.48 Very High Very High Very High
agonist 2 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heterotopic Ossification 25 100.00 Very High Very High Very High
Rheumatoid Arthritis 71 99.56 Very High Very High Very High
Cv Unclassified Under Development 7 99.52 Very High Very High Very High
Disease 557 99.22 Very High Very High Very High
Reperfusion Injury 7 99.16 Very High Very High Very High
INFLAMMATION 203 99.12 Very High Very High Very High
Injury 19 99.08 Very High Very High Very High
Targeted Disruption 15 99.08 Very High Very High Very High
Stress 35 98.48 Very High Very High Very High
Apoptosis 12 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that inhibition of COX-2-dependent prostacyclin might contribute to acceleration of atherogenesis in patients taking traditional nonsteroidal antiinflammatory drugs (NSAIDs) and NSAIDs selective for COX-2 through downregulation of HO-1, which halts TNF-alpha generation in human endothelial cells.
Negative_regulation (downregulation) of HO-1 in endothelial cells associated with inflammation, atherosclerosis and cinod
1) Confidence 0.51 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19122175 Disease Relevance 0.74 Pain Relevance 0.36
Morphine, de novo, had bimodal effects on HO activity: lower concentrations increased and higher concentrations decreased HO activity.
Negative_regulation (decreased) of HO associated with morphine
2) Confidence 0.45 Published 2003 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 12812915 Disease Relevance 0.66 Pain Relevance 0.89
AZD3582-induced blockade of free-radical formation was reversed in the presence of the HO-1 inhibitor, tin protoporphyrin-IX (SnPP).
Negative_regulation (inhibitor) of HO-1
3) Confidence 0.43 Published 2005 Journal Eur J Pharm Sci Section Abstract Doc Link 15911218 Disease Relevance 0.10 Pain Relevance 0.14
No significant inhibition of cyclo-oxygenase-1 is observed with rofecoxib up to doses of 1000 mg.
Negative_regulation (inhibition) of cyclo-oxygenase-1
4) Confidence 0.43 Published 1999 Journal Drugs Section Abstract Doc Link 10493277 Disease Relevance 0.22 Pain Relevance 0.22
On the other hand, zinc protoporphyrin, an inhibitor of HO activity, promoted GEC proliferation and inhibited GEC apoptosis under basal as well as morphine-stimulated conditions.
Negative_regulation (inhibitor) of HO in GEC associated with apoptosis and morphine
5) Confidence 0.38 Published 2003 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 12812915 Disease Relevance 0.99 Pain Relevance 1.15
Similarly to inhibition of prostacyclin biosynthesis or activity, the novel imidazole-based HO-1 inhibitor QC15 reversed TNF-alpha reduction by LSS.
Negative_regulation (inhibitor) of HO-1 associated with stress
6) Confidence 0.37 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19122175 Disease Relevance 0.73 Pain Relevance 0.37
The results suggest that upregulated TLR4 is associated with HO-1 reduction in PBMCs from patients with Beh├žet's disease, leading to augmented inflammatory responses.



Negative_regulation (reduction) of HO-1 associated with inflammatory response and disease
7) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2374472 Disease Relevance 0.94 Pain Relevance 0.11
Abnormal expression of TLR4 can predispose to defective HO-1 expression in BD PBMCs, because TLR4 may be a putative HO-1 repressor in hepatic ischemia/reperfusion injury mouse model [35].
Negative_regulation (repressor) of HO-1 associated with reperfusion injury, ischemia and disease
8) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.53 Pain Relevance 0.11
Similarly, real-time PCR analysis revealed a reduction in HO-1 mRNA levels in LPS-stimulated PBMCs (Figure 4a) when TNF mRNA expression was elevated (Figure 4b).
Negative_regulation (reduction) of HO-1 mRNA
9) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.44 Pain Relevance 0.03
On the other hand, a deficiency in HO-1 expression is associated with severe chronic inflammation, as demonstrated by studies conducted in HO-1 knockout mice [22] and observations in a patient with HO-1 deficiency [23].
Negative_regulation (deficiency) of HO-1 associated with targeted disruption and inflammation
10) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.66 Pain Relevance 0.41
Alternatively, specific intervention in TLR4-mediated signals that lead to HO-1 reduction may also be of benefit in BD.


Negative_regulation (reduction) of HO-1 associated with disease
11) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.39 Pain Relevance 0.16
However, reduced HO-1 levels in leukocytes have not been demonstrated in other rheumatic diseases.
Negative_regulation (reduced) of HO-1 in leukocytes associated with rheumatic diseases
12) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.95 Pain Relevance 0.16
Based on the data presented, we hypothesize that HSP60 stimulates not only antigen-specific autoimmune responses but also the innate immune system through constitutively over-expressed TLR4, which mediates HO-1 reduction in PBMCs, leading to inflammation in BD.
Negative_regulation (reduction) of HO-1 in immune system associated with inflammation and disease
13) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.36 Pain Relevance 0.15
In Hepa-1c1c7 cells transfected with si-SQSTM1 m3 and m4, the basal mRNA level of three Nrf2-regulated genes, heme oxygenase 1, GCLC, and NAD(P)H:quinone oxidoreductase 1, was reduced significantly, between 37 and 61% compared with si-CON-transfected cells (Fig. 4A).
Negative_regulation (reduced) of heme oxygenase 1 in Hepa-1c1c7
14) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
Interestingly, the HO is not limited to the areas where the resection arthroplasties were performed (although they are most abundant here), but it is present throughout the body.


Neg (not) Negative_regulation (limited) of HO in body associated with heterotopic ossification
15) Confidence 0.02 Published 2008 Journal Patient Saf Surg Section Body Doc Link PMC2584001 Disease Relevance 0.63 Pain Relevance 0.03
The inhibition of the cyclo-oxygenase isoform, cyclo-oxygenase-1 also promotes gastric injury, such effects involving the microcirculation.
Negative_regulation (inhibition) of cyclo-oxygenase-1 associated with injury
16) Confidence 0.01 Published 1999 Journal Ital J Gastroenterol Hepatol Section Abstract Doc Link 10379469 Disease Relevance 0.48 Pain Relevance 0.23
NSAIDs as inhibitors of cyclo-oxygenase-1 and cyclo-oxygenase-2
Negative_regulation (inhibitors) of cyclo-oxygenase-1 associated with cinod
17) Confidence 0.01 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130140 Disease Relevance 0.20 Pain Relevance 0.73
PLATELET INHIBITION: Conventional NSAIDs and aspirin have platelet-inhibiting properties via platelet cyclo-oxygenase-1 (Cox-1) isoenzyme inhibition.
Negative_regulation (inhibition) of cyclo-oxygenase-1 in platelet associated with aspirin and cinod
18) Confidence 0.01 Published 2003 Journal Presse Med Section Abstract Doc Link 14763353 Disease Relevance 0.26 Pain Relevance 0.49

General Comments

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