INT82461

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 40
Total Number 42
Disease Relevance 19.12
Pain Relevance 22.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gad2) lyase activity (Gad2) Golgi apparatus (Gad2)
cytoplasmic membrane-bounded vesicle (Gad2) plasma membrane (Gad2) cytoplasm (Gad2)
Anatomy Link Frequency
trigeminal ganglion 7
neurons 4
amygdala 3
nucleus 2
arcuate nucleus 2
Gad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 771 100.00 Very High Very High Very High
Glutamate 168 100.00 Very High Very High Very High
Dopamine 43 100.00 Very High Very High Very High
Enkephalin 25 99.90 Very High Very High Very High
Neurotransmitter 59 99.82 Very High Very High Very High
Antinociceptive 126 99.80 Very High Very High Very High
trigeminal ganglion 476 99.68 Very High Very High Very High
amygdala 15 99.64 Very High Very High Very High
dorsal root ganglion 6 99.56 Very High Very High Very High
Intracerebroventricular 2 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 294 100.00 Very High Very High Very High
Targeted Disruption 12 99.98 Very High Very High Very High
Hyperinsulinism 2 99.98 Very High Very High Very High
Ganglion Cysts 650 99.60 Very High Very High Very High
Parkinson's Disease 49 99.56 Very High Very High Very High
Neuropathic Pain 155 98.98 Very High Very High Very High
INFLAMMATION 70 98.84 Very High Very High Very High
Nociception 138 98.44 Very High Very High Very High
Pain 393 97.68 Very High Very High Very High
Peripheral Arterial Disease 42 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we constructed rAAV bearing GAD65 and demonstrated that GAD65 and GABA can be constitutively produced in the CNS.
Gene_expression (produced) of GAD65 associated with gaba
1) Confidence 0.78 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17466264 Disease Relevance 0.62 Pain Relevance 0.68
Both allodynic and hyperalgeic behavior tests suggested that neuropathic pain was noticeably reduced, along with the transgenic GAD65 expression.
Gene_expression (expression) of GAD65 associated with targeted disruption and neuropathic pain
2) Confidence 0.78 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17466264 Disease Relevance 0.80 Pain Relevance 0.84
The direct administration of rAAV-GAD65 to dorsal root ganglion induced constitutive GAD65 expression, which was readily detected by immunohistochemistry.
Gene_expression (expression) of GAD65 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
3) Confidence 0.78 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17466264 Disease Relevance 0.78 Pain Relevance 0.82
To investigate the beneficial effects of GAD65 produced by rAAV and resulting GABA release in peripheral neuropathic pain, we established a neuropathic pain rat model.
Gene_expression (produced) of GAD65 associated with gaba and neuropathic pain
4) Confidence 0.78 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17466264 Disease Relevance 0.71 Pain Relevance 0.71
Concomitantly, the significant enhancement in GABA release following transgenic GAD65 expression was identified in vivo.
Gene_expression (expression) of GAD65 associated with targeted disruption and gaba
5) Confidence 0.78 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17466264 Disease Relevance 0.76 Pain Relevance 0.82
In the amygdaloid complex, GAD65 is strongly expressed in striatal-like divisions, namely, the anterior amygdaloid area, the central nucleus (CEA), the intercalated nuclei, and the dorsal part of the medial nucleus (MEA).
Gene_expression (expressed) of GAD65 in amygdaloid area
6) Confidence 0.75 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.42
Second, we assessed the co-expression of preproenkephalin (ppENK) with GAD65, VGLUT1, or VGLUT2 by using double fluorescent in situ hybridization.
Gene_expression (expression) of GAD65
7) Confidence 0.75 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.41
The finding that adenovirus-mediated expression of GAD65 occurred principally in SGCs together with the presence of GABA receptor in the cell bodies of sensory neurons suggested that GABA might produce its antinociceptive effect inside the trigeminal ganglion in a paracrine manner.
Gene_expression (expression) of GAD65 in sensory neurons associated with ganglion cysts, gaba, trigeminal ganglion, gaba receptor and antinociceptive
8) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.50 Pain Relevance 0.77
GAD65 expression in the trigeminal ganglion produces analgesia in the orofacial formalin test
Gene_expression (expression) of GAD65 in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and analgesia
9) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.63 Pain Relevance 0.49
The principal evidence is that GAD65 expression was present principally in SGCs and only occasionally in neurons.
Gene_expression (expression) of GAD65 in neurons
10) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.65 Pain Relevance 0.95
We constructed rAAV-GAD65 expressing rat GAD65 and demonstrated that rat Parkinsonian symptoms can be significantly improved concomitantly with the production of GAD65.
Gene_expression (production) of GAD65 associated with parkinson's disease
11) Confidence 0.73 Published 2008 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 18642642 Disease Relevance 0.67 Pain Relevance 0.47
We constructed rAAV-GAD65 expressing rat GAD65 and demonstrated that rat Parkinsonian symptoms can be significantly improved concomitantly with the production of GAD65.
Gene_expression (expressing) of GAD65 associated with parkinson's disease
12) Confidence 0.73 Published 2008 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 18642642 Disease Relevance 0.66 Pain Relevance 0.44
Gene expression of the GAD67 and GAD65 isoforms of glutamate decarboxylase is differentially altered in subpopulations of striatal neurons in adult rats lesioned with 6-OHDA as neonates.
Gene_expression (expression) of GAD65 in neurons associated with glutamate and enkephalin
13) Confidence 0.73 Published 1999 Journal Synapse Section Title Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.36
The present results provide further evidence that GAD67 and GAD65 gene expression is differentially regulated in the two subpopulations of efferent striatal neurons.
Gene_expression (expression) of GAD65 gene in neurons
14) Confidence 0.73 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.36
In contrast, less than 25% of ENKergic cells expressed VGLUT1 in the lateral nucleus of the amygdale, with the majority of ENK cells expressing GAD65 mRNA in this nucleus.
Gene_expression (expressing) of GAD65 in nucleus
15) Confidence 0.65 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.19
We first established the detailed distribution of vesicular glutamate transporters 1 and 2 (VGLUT1 and -2) and glutamate decarboxylase 65 (GAD65) in the amygdala by using in situ hybridization.
Gene_expression (distribution) of glutamate decarboxylase 65 in amygdala associated with glutamate and amygdala
16) Confidence 0.65 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.44
We first established the detailed distribution of vesicular glutamate transporters 1 and 2 (VGLUT1 and -2) and glutamate decarboxylase 65 (GAD65) in the amygdala by using in situ hybridization.
Gene_expression (distribution) of GAD65 in amygdala associated with glutamate and amygdala
17) Confidence 0.65 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.44
The inhibitory neurotransmitter GABA is synthesized by glutamic acid decarboxylase (GAD), and two isoforms of this enzyme exist: GAD65 and GAD67.
Gene_expression (synthesized) of GAD65 associated with gaba, neurotransmitter and generalized anxiety disorder
18) Confidence 0.65 Published 2003 Journal Neuroscience Section Abstract Doc Link 12770560 Disease Relevance 0.24 Pain Relevance 0.30
For immunohistochemistry, on-slide sections were blocked for 1 hour in 5% normal goat serum (NGS) and 0.3% Triton X-100 in PBS, pH 7.4, and then incubated overnight in the primary antiserum: GAD65 (1:1,000), glutamine synthetase (1:5,000; AbCam), P75 (1:1000, Chemicon), Schwann2E (1:1000 Developmental Studies Hybridoma Bank, Baltimore), GLAST (1:16,000; Millipore), neurofilament 160 (NF160) (1:200; Sigma), GABAA receptor (1:500; Chemicon) and GABAB receptor ((1:10,000, Dr.
Gene_expression (receptor) of GAD65
19) Confidence 0.64 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.08 Pain Relevance 0.10
We constructed rAAV-GAD65 expressing rat GAD65 and demonstrated that rat Parkinsonian symptoms can be significantly improved concomitantly with the production of GAD65.
Gene_expression (expressing) of rAAV-GAD65 associated with parkinson's disease
20) Confidence 0.64 Published 2008 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 18642642 Disease Relevance 0.66 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox