INT82462

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.03
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gad2) lyase activity (Gad2) Golgi apparatus (Gad2)
cytoplasmic membrane-bounded vesicle (Gad2) plasma membrane (Gad2) cytoplasm (Gad2)
Anatomy Link Frequency
arcuate nucleus 6
neurons 2
Gad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 10 100.00 Very High Very High Very High
antagonist 7 97.00 Very High Very High Very High
Intracerebroventricular 3 95.56 Very High Very High Very High
dexamethasone 15 91.16 High High
agonist 6 88.52 High High
Dopamine 21 86.60 High High
GABAergic 11 86.00 High High
dopamine receptor 2 83.80 Quite High
tetrodotoxin 9 81.68 Quite High
Glutamate 2 75.36 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 23 98.90 Very High Very High Very High
Hyperinsulinism 3 94.08 High High
Disease 41 70.08 Quite High
Dyskinesias 43 68.52 Quite High
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Hypokinesia 2 5.00 Very Low Very Low Very Low
Dystonia 2 5.00 Very Low Very Low Very Low
Chorea 1 5.00 Very Low Very Low Very Low
Tremor 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, increases in the GABA-synthesizing enzyme glutamic acid decarboxylase 65 (GAD65) mRNA expression preceded decreases in NPY mRNA expression in the arcuate nucleus in the cultures.
Positive_regulation (increases) of Transcription (expression) of GAD65 in arcuate nucleus associated with gaba
1) Confidence 0.49 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.08 Pain Relevance 0.93
Quantitative analysis at the cellular level indicated that GAD67 mRNA levels were increased in PPE-labeled neurons, whereas GAD65 mRNA levels were increased in PPE-unlabeled neurons.
Positive_regulation (increased) of Transcription (levels) of GAD65 in neurons
2) Confidence 0.44 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.28
In the GPi of MPTP-treated monkeys, i.e., the main output structure, the expression of GAD67 and GAD65 mRNAs is increased (Pedneault and Soghomonian, 1994; Soghomonian et al., 1994; Herrero et al., 1996).
Positive_regulation (increased) of Transcription (expression) of GAD65 associated with parkinson's disease
3) Confidence 0.27 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.78 Pain Relevance 0.04
Furthermore, increases in the GABA-synthesizing enzyme glutamic acid decarboxylase 65 (GAD65) mRNA expression preceded decreases in NPY mRNA expression in the arcuate nucleus in the cultures.
Positive_regulation (increases) of Transcription (expression) of GABA-synthesizing enzyme glutamic acid decarboxylase 65 in arcuate nucleus associated with gaba
4) Confidence 0.25 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.08 Pain Relevance 0.93
Experiments in vivo also demonstrated that increases in GAD65 mRNA expression in the arcuate nucleus preceded decreases in the NPY mRNA expression in a fasting-refeeding paradigm and that intracerebroventricular injection of insulin increased GAD65 mRNA expression in the arcuate nucleus in fasted rats.
Positive_regulation (increases) of Transcription (expression) of GAD65 mRNA in arcuate nucleus associated with hyperinsulinism and intracerebroventricular
5) Confidence 0.20 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.09 Pain Relevance 0.84

General Comments

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