INT82465

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.47
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gad2) lyase activity (Gad2) Golgi apparatus (Gad2)
cytoplasmic membrane-bounded vesicle (Gad2) plasma membrane (Gad2) cytoplasm (Gad2)
Anatomy Link Frequency
neurons 4
nucleus 2
Gad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 4 100.00 Very High Very High Very High
Enkephalin 3 99.90 Very High Very High Very High
antagonist 2 97.12 Very High Very High Very High
Dopamine 25 91.76 High High
gABA 5 88.72 High High
dopamine receptor 3 86.28 High High
agonist 4 85.56 High High
opioid receptor 3 23.48 Low Low
Opioid 4 6.40 Low Low
positron emission tomography 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 41 94.08 High High
Parkinson's Disease 23 87.68 High High
Dyskinesias 43 44.16 Quite Low
Wheal 1 8.24 Low Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Hypokinesia 2 5.00 Very Low Very Low Very Low
Dystonia 2 5.00 Very Low Very Low Very Low
Chorea 1 5.00 Very Low Very Low Very Low
Tremor 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results provide further evidence that GAD67 and GAD65 gene expression is differentially regulated in the two subpopulations of efferent striatal neurons.
Regulation (regulated) of Gene_expression (expression) of GAD65 gene in neurons
1) Confidence 0.58 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.36
Gene expression of the GAD67 and GAD65 isoforms of glutamate decarboxylase is differentially altered in subpopulations of striatal neurons in adult rats lesioned with 6-OHDA as neonates.
Regulation (altered) of Gene_expression (expression) of GAD65 in neurons associated with glutamate and enkephalin
2) Confidence 0.58 Published 1999 Journal Synapse Section Title Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.40
In rats, an ipsilateral marked up-regulation of GAD65/67 mRNA expression in the ENT nucleus has been reported following 6-OHDA lesion (Soghomonian and Chesselet, 1992; Barroso-Chinea et al., 2008).
Regulation (regulation) of Gene_expression (expression) of GAD65 in nucleus
3) Confidence 0.16 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.47 Pain Relevance 0

General Comments

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